Jagadeesh Narasimhappagari

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UAMS

3 pubs

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Jagadeesh Narasimhappagari's research investigates the molecular mechanisms underlying neurodegenerative diseases and their potential modulation by pharmacological agents. His work has explored the role of interleukin-1β-induced inflammatory signaling and its impact on myelin-related alterations in oligodendroglia and Schwann cells, particularly in the context of multiple sclerosis. Narasimhappagari has also studied how ibuprofen can modulate inflammatory and autophagy-associated pathways in cellular models relevant to neurodegenerative pathology, noting APOE-context-dependent effects. Additionally, his research has examined the inverse relationship between cancer and Alzheimer's disease, focusing on the interplay between autophagy and apoptosis signaling mechanisms. His recent publications include work on these topics, with key collaborators including W. Sue T. Griffin and Srinivas Ayyadevara from the University of Arkansas for Medical Sciences.

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Publications: 3

Selected Publications

Interleukin-1β-Induced Inflammatory Signaling and Myelin-Related Alterations in Oligodendroglia and Schwann Cells in Multiple Sclerosis: Modulatory Effects of Ibuprofen and Flurbiprofen (2026)

Current Issues in Molecular Biology DOI OpenAlex
Ibuprofen modulates inflammatory and autophagy-associated pathways linked to neurodegenerative pathology in APOE-context-dependent cellular models (2026)

Journal of Neuroinflammation DOI OpenAlex
Abstract LB320: Inverse relationship between cancer and Alzheimer’s disease: Important interplay between autophagy and apoptosis signaling mechanisms (2026)

Cancer Research DOI OpenAlex