A
Abdelrahman Y. Fouda
Federal Grant PI
High Impact
Associate Professor with tenure
faculty
Pharmacology & Toxicology, College of Medicine
28 h-index
89 pubs
2,060 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Abdelrahman Y. Fouda's research focuses on understanding and treating retinal and brain injuries, particularly those resulting from ischemia and reperfusion. He investigates the role of arginase enzymes, specifically arginase 1 and arginase 2, in mediating these injuries. His work has explored how arginase 1 can limit neovascularization in the retina and promote angiogenic repair, while also examining its interaction with other pathways, such as the ornithine decarboxylase pathway, to suppress inflammatory responses in myeloid cells. This research has implications for developing treatments for ischemic retinopathies.
Fouda also studies the mechanisms underlying vision restoration and neuroprotection. His work includes investigating the repopulation of retinal ganglion cells for vision restoration in optic neuropathy and exploring the potential of boosting efferocytosis for retinal neurovascular protection. He has received federal funding from the NIH/National Eye Institute for two projects, totaling over $500,000, focusing on the role of arginase 1 in retinal ischemia-reperfusion injury and on enhancing retinal neurovascular protection through efferocytosis. His scholarship metrics include an h-index of 28, 87 total publications, and 2,020 total citations, designating him as a highly cited researcher.
Metrics
- h-index: 28
- Publications: 89
- Citations: 2,060
Selected Publications
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Myeloid HDAC3 deletion protects against traumatic optic injury (2026)
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A metabolic switch in retinal angiogenesis: Histone deacetylase 3 (2026)
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Recent advances and future challenges in nanosystems for ocular drug delivery (2025)
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Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025)
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Myeloid HDAC3 Deletion Protects Against Traumatic Optic Injury (2025)
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Extracellular Vesicle Metabolomics Holds Promise for Adult Axon Regeneration (2025)
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Disrupting the CD47/SIRPα Axis Protects Against Traumatic Optic Neuropathy (2025)
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HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164) (2025)
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Disrupting the CD47/SIRPα Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422) (2025)
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Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy (2025)
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Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024)
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Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush (2023)
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Multi-color Flow Cytometry Protocol to Characterize Myeloid Cells in Mouse Retina Research (2023)
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The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis (2022)
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Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair (2022)
Federal Grants 2 $502,702 total
NIH/National Eye Institute
Contact PI
Sep 2024 - May 2029
NIH/National Eye Institute
Contact PI
Sep 2019 - Jan 2026
Grants & Funding
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Role of Arginase 1 in Retinal Ischemia Reperfusion Injury NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
- Retinal neurovascular protection by boosting efferocytosis NIH/Nat. Eye Institute Principal Investigator
Collaboration Network
Top Collaborators
Esraa Shosha
Cairo University
17 shared publications
In database
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Showing 5 of 17 shared publications
Ruth B. Caldwell
Discovery Institute (US)
11 shared publications
- Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Showing 5 of 11 shared publications
Carol Morris
University of Arkansas for Medical Sciences
10 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Multi-color Flow Cytometry Protocol to Characterize Myeloid Cells in Mouse Retina Research
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
Showing 5 of 10 shared publications
Rami Ahmad Shahror
University of Arkansas for Medical Sciences
9 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Multi-color Flow Cytometry Protocol to Characterize Myeloid Cells in Mouse Retina Research
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
Showing 5 of 9 shared publications
Zhimin Xu
Augusta University Health (US)
7 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis
Showing 5 of 7 shared publications
Tahira Lemtalsi
Discovery Institute (US)
7 shared publications
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
Showing 5 of 7 shared publications
Robert W. Caldwell
Augusta University (US)
7 shared publications
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
Showing 5 of 7 shared publications
Nancy J. Rusch
University of Arkansas for Medical Sciences
6 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Opinion: Endothelial Cells - Macrophage-Like Gatekeepers?
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- The role of efferocytosis in ischemic stroke and insights from retinopathy
Showing 5 of 6 shared publications
Melissa Wild
University of Arkansas for Medical Sciences
5 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- Disrupting the CD47/SIRPα Axis Protects Against Traumatic Optic Neuropathy
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
Syed Zaidi
Discovery Institute (US)
4 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
S. Priya Narayanan
University of Georgia (US)
4 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
- The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis
Christian D. Mitchell
University of Arkansas for Medical Sciences
4 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164)
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
Fang Liu
Discovery Institute (US)
3 shared publications
- Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
- The mouse model of experimental autoimmune encephalomyelitis: Methods to study neuroinflammation in optic neuritis
Paul N. Cheng
3 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Pegylated Arginase 1 as a Treatment for Acute Central Nervous System (CNS) Injury
Modesto Rojas
Augusta University (US)
3 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
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