Francesca V. LoBianco

Researcher

University of Arkansas for Medical Sciences

faculty

5 h-index 14 pubs 86 cited

Research Areas

Cancer-related molecular mechanisms research Drug-Induced Hepatotoxicity and Protection Mitochondrial Function and Pathology Pharmacological Effects and Toxicity Studies Neuroscience and Neuropharmacology Research Metabolism and Genetic Disorders Health and Medical Research Impacts

Links

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OverviewAI-generated summary

Francesca V. LoBianco's research investigates the molecular mechanisms underlying cellular damage and disease, with a focus on cancer and age-related conditions. Her work has explored how specific compounds, such as parthenolide, can induce ferroptosis, a regulated form of cell death, in hepatocellular carcinoma cells by oxidizing thiols. LoBianco also studies the role of drug metabolism, specifically cytochrome P450 3A4, in the hepatotoxicity of cancer therapeutics like sorafenib and lapatinib. Another area of her research examines the impact of Sirt3 on mitochondrial function, specifically the activity of MnSOD, and its subsequent effects on physiology and cognition in aged murine models. She has authored or co-authored 14 publications, with a total of 86 citations, and holds an h-index of 5. LoBianco collaborates with several researchers at the University of Arkansas for Medical Sciences, including Nükhet Aykin‐Burns, Kimberly J. Krager, A’Vonte Jones, and Antiño R. Allen.

Metrics

  • h-index: 5
  • Publications: 14
  • Citations: 86

Selected Publications

  • The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity (2023) DOI
  • Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023) DOI
  • Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022) DOI
  • Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022) DOI
  • Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells (2022) DOI
  • Overcoming the Restricted Therapy Options and Monitoring Challenges in Metastatic Breast Cancer (2021) DOI
  • Abstract No. 584 Parthenolide induces thiol oxidation inducing ferroptosis in human hepatocellular carcinoma cells (2021) DOI

Collaborators

Researchers in the database who share publications

Nükhet Aykin‐Burns University of Arkansas for Medical Sciences 7 shared publications Kimberly J. Krager University of Arkansas for Medical Sciences 6 shared publications A’Vonte Jones University of Arkansas for Medical Sciences 3 shared publications Antiño R. Allen University of Arkansas for Medical Sciences 2 shared publications Grover Miller University of Arkansas for Medical Sciences 1 shared publication Mitchell R. McGill University of Arkansas for Medical Sciences 1 shared publication Yihong Kaufmann University of Arkansas for Medical Sciences 1 shared publication A. Tascioglu-Aliyev University of Arkansas for Medical Sciences 1 shared publication

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