Francesca V. LoBianco

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UAMS

Formerly Arkansas Affiliated with UAMS through 2023; recent publications list University of Illinois Chicago.

5 h-index 14 pubs 86 cited

Research Areas

Biomedical Subjects

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ORCID

OverviewAI-generated summary

Francesca V. LoBianco's research focuses on cellular mechanisms related to disease, particularly in the context of cancer and aging. She investigates the role of Sirtuin 3 (Sirt3) in mitochondrial function, oxidative stress, and cognition, utilizing aged murine models. Her work also examines the induction of ferroptosis, a form of programmed cell death, in hepatocellular carcinoma cells, exploring the impact of compounds like parthenolide and the role of cytochrome P450 3A4-mediated metabolism in drug-induced hepatotoxicity. LoBianco has also contributed to the development and characterization of porcine hepatocellular carcinoma models for translational research and has assessed cellular oxidation using compartment-specific redox-sensitive green fluorescent protein. Her collaborators include Nükhet Aykin‐Burns, Kimberly J. Krager, Antiño R. Allen, and A’Vonte Jones, all from the University of Arkansas for Medical Sciences.

Metrics

h-index: 5
Publications: 14
Citations: 86

Selected Publications

The Role of Cytochrome P450 3A4-Mediated Metabolism in Sorafenib and Lapatinib Hepatotoxicity (2023)

Livers 12 citations DOI OpenAlex
Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model (2023)

Behavioural Brain Research 9 citations DOI OpenAlex
Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, And Cognition in an Aged Murine Model (2022)

SSRN Electronic Journal DOI OpenAlex
Effect of Sirt3 on Hippocampal MnSOD Activity, Mitochondrial Function, Physiology, and Cognition in an Aged Murine Model (2022)

SSRN Electronic Journal DOI OpenAlex
Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells (2022)

Frontiers in Toxicology 19 citations DOI OpenAlex
Overcoming the Restricted Therapy Options and Monitoring Challenges in Metastatic Breast Cancer (2021)

Toxicology Letters DOI OpenAlex
Abstract No. 584 Parthenolide induces thiol oxidation inducing ferroptosis in human hepatocellular carcinoma cells (2021)

Journal of Vascular and Interventional Radiology DOI OpenAlex
Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein (2020)

Journal of Visualized Experiments DOI OpenAlex
Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation (2020)

Oncotarget 34 citations DOI OpenAlex
Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein (2020)

Journal of Visualized Experiments 1 citation DOI OpenAlex
The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury (2020)

Antioxidants 16 citations DOI OpenAlex
Abstract No. 428 Parthenolide induces thiol oxidation-mediated cytotoxicity in human and rat hepatocellular carcinoma cell lines (2020)

Journal of Vascular and Interventional Radiology DOI OpenAlex
03:27 PM Abstract No. 221 Porcine and human hepatocellular carcinoma cell lines present similar drug-metabolizing enzyme expression levels and comparable sorafenib and doxorubicin cytotoxic responses (2019)

Journal of Vascular and Interventional Radiology DOI OpenAlex