Gwen V. Childs
Distinguished Professor
Also affiliated: Ain Shams University (1986); Northwestern University (1977–1983); Utah State University (1984); Brigham and Women's Hospital (1987–1991); National Institutes of Health (1982–1986); Howard Hughes Medical Institute (1987–1992); Harvard University (1987–1991); North Carolina State University (1996); Baylor University (1987–2001); Tel Aviv University (1987); University of New Mexico (1984); Baylor College of Medicine (1987–1990); Augusta University (2004); University of Arkansas Medical Center (2001–2014); Harvard University Press (1992); University of Alabama at Birmingham (2020–2024); Augusta University Health (2002); Massachusetts General Hospital (1987); National Institute of Child Health (1982–1986); University Hospital of Geneva (1987); Center for Neurosciences (2019); Center for Translational Molecular Medicine (2019); Eunice Kennedy Shriver National Institute of Child Health and Human Development (1982–1985); Arkansas Department of Agriculture (2020); Health and Human Development (2HD) Research Network (1982–2019); Weizmann Institute of Science (1986–1987); The University of Texas Medical Branch at Galveston (1981–2003); University of Nebraska Medical Center (1975–1982)
Faculty Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Gwen V. Childs is a Distinguished Professor at the University of Arkansas for Medical Sciences. Her research focuses on the molecular mechanisms underlying pituitary gland function and plasticity. She has received significant funding from the National Institutes of Health (NIH) for her work, including an R01 grant awarded early in her career. Current federal funding includes three awards totaling over $1.7 million: one from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) investigating the impact of obesity on somatotrope function, and two from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and NIDDK, respectively, exploring control of pituitary cell plasticity through regulated mRNA translation and the molecular mechanisms of pituitary plasticity.
Childs' recent publications investigate topics such as adipo-glial signaling in peripheral nerve regeneration, the regulatory landscape of murine pituitary using single nucleus multi-omics, and the impact of high-fat diets on anterior pituitary transcriptomics, particularly concerning oxidative stress and cell metabolism. Her work also delves into the role of Musashi RNA-binding proteins in controlling gonadotrope target mRNA translation during the mouse estrous cycle and the post-transcriptional regulation of Gnrhr as a metabolic control checkpoint in female reproduction. She has authored or co-authored over 270 publications and has a citation count of over 7,000, with an h-index of 49. Childs actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Angus M. MacNicol, Melanie C MacNicol, Angela K. Odle, and Alex Lagasse.
Metrics
- h-index: 47
- Publications: 267
- Citations: 6,702
Selected Publications
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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Solving the Mystery of the Neonatal GH Surge (2024)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024)
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Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024)
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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023)
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Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration (2023)
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FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023)
Federal Grants 3 $1,783,459 total
Control of pituitary cell plasticity through regulated mRNA translation
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Regulation of Leptin Production by Gonadotropes NIH
- Regulation of Leptin Expression and Function in the Anterior Pituitary National Science Foundation
- Significance of Pituitary Leptin to Gonadotropes NIH
- DEAP Award-Childs UAMS College of Medicine
- FUNCTIONAL DIFFERENTIATION OF CORTICOTROPES NIH
- Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes NIH
- 120 kV FEI Electron Microscope and Supporting Sample Preparation Equipment for Biological Microscopy National Science Foundation
- Tropic Roles for Leptin in the Maturation of Somatotropes NIH
- Cellular Basis for Non-Parallel Gonadotropin Release NIH
- Center for Translational Neuroscience NIH
- HORMONE STORAGE AND SECRETION BY GONADOTROPES NIH
- Cloning and Functional Characterization of an Avian Pituitary Gland Vasotocin Receptor National Science Foundation
- The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes NIH
- NOVEL SOMATOTROPE FUNCTIONS DURING OVULATION NIH
- Leptin Molecular Regulatory Mechanisms That Prevent Growth hormone Deficiency NIH
Collaboration Network
Top Collaborators
- Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 22 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
Showing 5 of 22 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
Showing 5 of 20 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 14 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
Showing 5 of 13 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 12 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 8 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Musashi1 RNA-Binding Protein Functions as a Leptin-Regulated Enforcer of Pituitary Cell Fate and Hormone Production
Showing 5 of 7 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
Showing 5 of 7 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
Showing 5 of 6 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
- OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Musashi1 RNA-Binding Protein Functions as a Leptin-Regulated Enforcer of Pituitary Cell Fate and Hormone Production
- SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages.
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Cell Fate Determinant Musashi Is Controlled Through Dynamic Protein:Protein Interactions
- SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages.
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
- 410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
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