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Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-08

Ashley Herdman

Researcher

Faculty Researcher

2 h-index 12 pubs 19 cited

  • Pituitary Gland
  • Animals
  • Female
  • Mice
  • Diet, High-Fat
  • Somatotrophs
  • Receptors, Leptin
  • Aging
  • Mice, Inbred C57BL
  • Signal Transduction
  • Leptin
  • Transcriptome
  • Male
  • Obesity
  • Gene Expression Profiling

Biography and Research Information

OverviewAI-generated summary

Ashley Herdman's research investigates the molecular mechanisms underlying pituitary gland function, particularly in response to dietary factors and hormonal signaling. Herdman's work has examined the transcriptomic changes in the anterior pituitary following a high-fat diet, exploring the impact of oxidative stress on cellular metabolism. Further studies have focused on the role of leptin receptor signaling in somatotrope maturation in female mice and how its ablation affects pituitary plasticity, especially in the context of aging and high-fat diets. Herdman has also explored the influence of secretogranin II-derived peptides, such as secretoneurin, on luteinizing hormone secretion and gonadotrope function, investigating these effects in relation to age and sex. Collaborations with Angela K. Odle, Melanie C MacNicol, Angus M. MacNicol, and Alex Lagasse have resulted in nine shared publications, indicating a strong network within the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 2
  • Publications: 12
  • Citations: 19

Selected Publications

  • Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
    Biology of Reproduction 1 citation DOI OpenAlex
  • Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
    Biology of Reproduction DOI OpenAlex
  • OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
    Journal of the Endocrine Society DOI OpenAlex
  • SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
    Journal of the Endocrine Society DOI OpenAlex
  • High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
    Frontiers in Endocrinology 1 citation DOI OpenAlex
  • Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
    Endocrinology 5 citations DOI OpenAlex
  • 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
    Journal of the Endocrine Society DOI OpenAlex
  • Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023)
    Endocrinology 12 citations DOI OpenAlex
  • FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023)
    Journal of the Endocrine Society DOI OpenAlex

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Collaboration Network

16 Collaborators 5 Institutions 2 Countries

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