Isabelle R. Miousse
Federal Grant PI
High Impact
Assistant Professor
faculty
Biochemistry & Molecular Biology, College of Medicine
29 h-index
92 pubs
2,991 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Isabelle R. Miousse is an Assistant Professor in the Department of Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences. Her research focuses on the intersection of metabolism, particularly methionine, and its role in cellular responses to radiation and cancer. She investigates how dietary interventions, such as methionine restriction, can influence treatment outcomes for conditions like colorectal cancer and acute radiation syndrome.
Miousse's work also explores the potential of radioprotective agents, such as Gamma-Tocotrienol, in mitigating the effects of radiation exposure. Her studies have involved various model systems, including nonhuman primates and inbred mice, to understand the complex biological mechanisms involved. She has received federal funding from the NIH for her research on methionine metabolism in the acute response to radiation in the gut.
With a h-index of 29 and over 2,900 citations across 88 publications, Miousse is recognized as a highly cited researcher. She actively collaborates with colleagues at the University of Arkansas for Medical Sciences, including Sarita Garg, Lauren C. Morehead, Alan J. Tackett, and Katherine Wallis, contributing to a robust network of research endeavors.
Metrics
- h-index: 29
- Publications: 92
- Citations: 2,991
Selected Publications
-
Abstract 4378: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2026)
-
Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025)
-
Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
-
Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2025)
-
Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025)
-
GLP-1 receptor agonists in the context of cancer: the road ahead (2025)
-
Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response (2025)
-
Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024)
-
Rescue of Methionine Dependence by Cobalamin in a Human Colorectal Cancer Cell Line (2024)
-
Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation (2023)
-
Climate Change and New Challenges for Rural Communities: Particulate Matter Matters (2023)
-
Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023)
-
Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023)
-
Characterization of methionine dependence in melanoma cells (2023)
-
Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023)
Federal Grants 1 $153,000 total
NIH/NIH Office of the Director
Contact PI
Aug 2025 - Jul 2027
Methionine metabolism in the acute response to radiation in the gut
Grants & Funding
- Team Leader for the Radiation Effects Team National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine Co-Investigator
- Synergizing methionine restriction with radiation therapy in KRAS mutant rectal cancer UAMS Cancer Institute Team Award Co-Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Methionine restriction as an adjuvant therapy in melanoma NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of Arkansas at Fayetteville Principal Investigator
- Methionine metabolism in the acute response to radiation in the gut NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Decreasing methionine intake to improve survival in patients with metastatic melanoma UAMS CTSA Other
- Methionine metabolism in the acute response to radiation in the gut NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
- Methionine and autophagy in metastatic melanoma Barton Endowment, UAMS college of Medicine Principle Investigator
Collaboration Network
Top Collaborators
Sarita Garg
University of Arkansas for Medical Sciences
14 shared publications
In database
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Showing 5 of 14 shared publications
Lauren C. Morehead
University of Arkansas for Medical Sciences
9 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Characterization of methionine dependence in melanoma cells
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
Showing 5 of 9 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
9 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Characterization of methionine dependence in melanoma cells
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 9 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
7 shared publications
In database
- Differences in cell death in methionine versus cysteine depletion
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
Showing 5 of 7 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
7 shared publications
In database
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
Showing 5 of 7 shared publications
Igor Koturbash
University of Arkansas for Medical Sciences
5 shared publications
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
- Climate Change and New Challenges for Rural Communities: Particulate Matter Matters
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
Marjan Boerma
Winthrop Rockefeller Foundation
4 shared publications
In database
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
- Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure
- Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
Tarun K. Garg
University of Arkansas for Medical Sciences (US)
4 shared publications
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
Stephen Y. Wise
Uniformed Services University of the Health Sciences (US)
4 shared publications
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
Oluseyi O. Fatanmi
Uniformed Services University of the Health Sciences (US)
4 shared publications
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
Alexei G. Basnakian
University of Arkansas for Medical Sciences
4 shared publications
In database
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response
Vijay K. Singh
Uniformed Services University of the Health Sciences (US)
4 shared publications
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
- Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model
- Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation
Eric R. Siegel
University of Arkansas for Medical Sciences
4 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction
- Increased response to immune checkpoint inhibitors with dietary methionine restriction
- Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response
Camila Simões
University of Arkansas for Medical Sciences
4 shared publications
In database
- Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
Khandoker Usran Ferdous
University of Arkansas for Medical Sciences
4 shared publications
In database
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer
- Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response
- Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models
Similar Researchers
Based on overlapping research topics
Sarita Garg
University of Arkansas for Medical Sciences
Diet and metabolism studies
Cancer Treatment and Pharmacology
Immune Response and Inflammation
Perry C. Caviness
University of Arkansas for Medical Sciences
Diet and metabolism studies
Epigenetics and DNA Methylation
Metabolism and Genetic Disorders
Rosalia C. M. Simmen
University of Arkansas for Medical Sciences
Diet and metabolism studies
Immune Response and Inflammation
Metabolism and Genetic Disorders
Jilliyn Jeu
University of Arkansas for Medical Sciences
Diet and metabolism studies
Immune Response and Inflammation
Metabolism and Genetic Disorders
R. Racine
University of Arkansas for Medical Sciences
Diet and metabolism studies
Radiation Therapy and Dosimetry
Immune Response and Inflammation
Lora J. Rogers
University of Arkansas for Medical Sciences
Diet and metabolism studies
Epigenetics and DNA Methylation
Cancer Treatment and Pharmacology