Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
J
James C. Fuscoe
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
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Also affiliated: University of Vermont (1993); Lawrence Livermore National Laboratory (1985–2008); Oak Ridge National Laboratory (1978–1982); Centre National de la Recherche Scientifique (1995); Arkansas Children's Hospital (2009); Environmental Protection Agency (1993–2003); St. Jude Children's Research Hospital (1998); United States Food and Drug Administration (2003–2026); Center for Drug Evaluation and Research (2020); Howard Hughes Medical Institute (1983–1984); University of Connecticut (1991); Illumina (United States) (2014); Baylor College of Medicine (1982–1984); Integrated Laboratory Systems, Inc. (1994); Louisiana State University Health Sciences Center New Orleans (2008); Institut Curie (1995)
47 h-index
168 pubs
13,553 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
James C. Fuscoe's research centers on understanding and identifying biomarkers for drug-induced toxicities, particularly cardiotoxicity. His work has investigated the mechanisms behind doxorubicin-induced cardiotoxicity, exploring its delayed-onset and subclinical manifestations in preclinical models.
His recent publications highlight the potential of microRNA-34a-5p as an early circulating biomarker for chronic cardiotoxicity. Fuscoe has also examined the role of the apelin-APJ pathway in sex-related differential cardiotoxicity caused by doxorubicin. Furthermore, his research includes studies on predictive risk factors for myocardial injury in pediatric patients treated with anthracyclines.
Fuscoe holds a high-impact researcher designation, evidenced by his h-index of 47 and over 13,000 citations across 168 publications. He collaborates with researchers at the National Center for Toxicological Research and the University of Arkansas for Medical Sciences, maintaining an active laboratory website.
Metrics
- h-index: 47
- Publications: 168
- Citations: 13,553
Selected Publications
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Correction: Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study (2026)
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Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study (2025)
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Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022)
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MicroRNA‐34a‐5p as a promising early circulating preclinical biomarker of doxorubicin‐induced chronic cardiotoxicity (2022)
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Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice (2021)
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Simultaneous Quantification of t(14;18) and HPRT Exon 2/3 Deletions in Human Lymphocytes (2020)
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A comprehensive rat transcriptome built from large scale RNA-seq-based annotation (2020)
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Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism (2020)
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Rebuttal to the comments by Dr. Yan Xu on the article “Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone” (2019)
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Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice (2018)
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Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone (2018)
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Transcriptomics analysis of early embryonic stem cell differentiation under osteoblast culture conditions: Applications for detection of developmental toxicity (2017)
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Sex and age differences in the expression of liver microRNAs during the life span of F344 rats (2017)
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Stably Expressed Genes Involved in Basic Cellular Functions (2017)
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Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice (2016)
Collaboration Network
Top Collaborators
Varsha G. Desai
National Center for Toxicological Research
34 shared publications
In database
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Analysis of variance components in gene expression data
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
- Age and sex differences in kidney microRNA expression during the life span of F344 rats
Showing 5 of 34 shared publications
Carrie L. Moland
National Center for Toxicological Research
31 shared publications
In database
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
- Age and sex differences in kidney microRNA expression during the life span of F344 rats
Showing 5 of 31 shared publications
Tao Han
National Center for Toxicological Research (US)
27 shared publications
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
- QA/QC: challenges and pitfalls facing the microarray community and regulatory agencies
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples
Showing 5 of 27 shared publications
Huixiao Hong
National Center for Toxicological Research
20 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
Showing 5 of 20 shared publications
Weida Tong
National Center for Toxicological Research
20 shared publications
In database
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project
- ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research.
Showing 5 of 20 shared publications
Vikrant Vijay
National Center for Toxicological Research
19 shared publications
In database
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Age and sex differences in kidney microRNA expression during the life span of F344 rats
- Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages
- Sex differences in kidney gene expression during the life cycle of F344 rats
- Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice
Showing 5 of 19 shared publications
William S. Branham
National Center for Toxicological Research (US)
17 shared publications
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Microarray scanner calibration curves: characteristics and implications
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
- Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements.
Showing 5 of 17 shared publications
Taewon Lee
Department of Mathematical Sciences (RU)
17 shared publications
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice
- Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice
Showing 5 of 17 shared publications
Leming Shi
National Center for Toxicological Research (US)
15 shared publications
- Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project
- The External RNA Controls Consortium: a progress report
- ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research.
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 15 shared publications
Lei Guo
National Center for Toxicological Research
14 shared publications
In database
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 14 shared publications
Zhenqiang Su
National Center for Toxicological Research (US)
13 shared publications
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 13 shared publications
Roger Perkins
United States Food and Drug Administration (US)
11 shared publications
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research.
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
Showing 5 of 11 shared publications
Leming Shi
Fudan University (CN)
10 shared publications
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats
Showing 5 of 10 shared publications
Hong Fang
National Center for Toxicological Research
10 shared publications
In database
- The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research.
- Microarray scanner calibration curves: characteristics and implications
- Development of public toxicogenomics software for microarray data management and analysis
Showing 5 of 10 shared publications
Federico Goodsaid
United States Food and Drug Administration (US)
9 shared publications
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The External RNA Controls Consortium: a progress report
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 9 shared publications
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