K
Kevin A. Murach Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Researcher
faculty
35 h-index
151 pubs
3,759 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Kevin A. Murach's research focuses on the molecular and cellular mechanisms that regulate skeletal muscle adaptation and regeneration, particularly in the context of aging. His work investigates how exercise influences muscle metabolism and how cellular processes, such as satellite cell activity and epigenetic modifications, contribute to long-term muscle growth and repair.
Murach's federally funded research includes two grants from the NIH/National Institute on Aging, totaling $526,126. These grants support his investigations into the role of myonuclear epigenetics in skeletal muscle mass regulation with age and the mediators of muscle rejuvenation. His publications have explored topics including the epigenetic aging of skeletal muscle, the use of senolytics to improve muscle regeneration in older mice, and the formation of epigenetic "memory" in skeletal muscle following prior adaptation.
With a career h-index of 35 and over 3,630 citations across 146 publications, Murach is recognized as a highly cited researcher. He actively collaborates with colleagues at the University of Arkansas at Fayetteville, including Nicholas P. Greene, Francielly Morena da Silva, Pieter J Koopmans, and Sabin Khadgi, with whom he has co-authored multiple publications.
Metrics
- h-index: 35
- Publications: 151
- Citations: 3,759
Selected Publications
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle (2025)
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Making sense of MYC in skeletal muscle: location, duration, and magnitude (2025)
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Power and Endurance: Polar Opposites or Willing Partners? (2025)
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microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism (2025)
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Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice (2025)
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At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( <scp>BI01</scp> ) Administration on <scp>DNA</scp> Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle (2025)
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A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review (2025)
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A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity (2025)
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A primer on global molecular responses to exercise in skeletal muscle: Omics in focus (2025)
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The expanding roles of myonuclei in adult skeletal muscle health and function (2024)
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The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth (2024)
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Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex (2024)
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Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024)
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Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci (2024)
Federal Grants 3 $526,126 total
NIH/National Institute on Aging
Contact PI
Jun 2025 - Jul 2030
NIH/National Institute on Aging
Contact PI
Aug 2023 - Apr 2028
NIH/National Institute on Aging
Contact PI
Aug 2019 - Jul 2025
Myonuclear Epigenetics of Skeletal Muscle Mass Regulation with Age
Collaboration Network
Top Collaborators
Yuan Wen
University of Kentucky (US)
19 shared publications
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Showing 5 of 19 shared publications
John J. McCarthy
University of Kentucky (US)
17 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Early satellite cell communication creates a permissive environment for long-term muscle growth
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Showing 5 of 17 shared publications
Christopher S. Fry
University of Kentucky (US)
16 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
- Early satellite cell communication creates a permissive environment for long-term muscle growth
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
Showing 5 of 16 shared publications
Nicholas P. Greene
University of Arkansas at Fayetteville
15 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
Showing 5 of 15 shared publications
Ferdinand von Walden
Karolinska Institutet (SE)
13 shared publications
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
Showing 5 of 13 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
13 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Showing 5 of 13 shared publications
Cory M. Dungan
Baylor University (US)
12 shared publications
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
- Early satellite cell communication creates a permissive environment for long-term muscle growth
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
Showing 5 of 12 shared publications
Charlotte A. Peterson
University of Kentucky (US)
11 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
- Early satellite cell communication creates a permissive environment for long-term muscle growth
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
Showing 5 of 11 shared publications
Nicholas T. Thomas
University of Kentucky (US)
9 shared publications
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy
- Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
Showing 5 of 9 shared publications
Sabin Khadgi
University of Arkansas at Fayetteville
9 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
Showing 5 of 9 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
9 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
Showing 5 of 9 shared publications
Vandré C. Figueiredo
University of Kentucky (US)
8 shared publications
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy
Showing 5 of 8 shared publications
Pieter J. Koopmans
University of Arkansas at Fayetteville (US)
8 shared publications
- The roles of miRNAs in adult skeletal muscle satellite cells
- Going nuclear: Molecular adaptations to exercise mediated by myonuclei
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
Showing 5 of 8 shared publications
Ivan J. Vechetti
University of Nebraska–Lincoln (US)
7 shared publications
- Early satellite cell communication creates a permissive environment for long-term muscle growth
- Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy
Showing 5 of 7 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
7 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Showing 5 of 7 shared publications
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