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Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
K
Kevin A. Murach
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Researcher
Also affiliated: James Madison University (2012–2016); Limestone College (2017); University of Kentucky (2016–2023); Ball State University (2012–2018); Albert B. Chandler Hospital (2015–2016); California Pacific Medical Center (2015); Institute on Aging (2015); National Institute on Aging (2015); Society for Muscle Biology (2020); Gallagher (United States) (2024); Arkansas Department of Health (2022); San Francisco State University (2015)
Faculty Researcher
36 h-index
160 pubs
4,020 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Kevin A. Murach's research focuses on the molecular and cellular mechanisms underlying skeletal muscle adaptation and regeneration, particularly in the context of aging. His work investigates how exercise influences muscle growth and how these processes change with age. Murach has received federal funding from the NIH/National Institute on Aging for projects examining the role of myonuclear epigenetics in skeletal muscle mass regulation and identifying mediators of muscle rejuvenation during aging. His research group also explores the contributions of satellite cells, crucial for muscle repair and growth, to age-related changes in muscle adaptation and investigates the potential of senolytic treatments to improve muscle regeneration in older individuals.
His scholarly output includes numerous publications in peer-reviewed journals, contributing to the understanding of exercise metabolism, epigenetic regulation of muscle, and cellular communication in muscle adaptation. Murach's work has been recognized with a high-impact researcher designation due to his citation count. He collaborates with other researchers at the University of Arkansas at Fayetteville, including Nicholas P. Greene, Francielly Morena da Silva, Pieter J. Koopmans, and Sabin Khadgi.
Metrics
- h-index: 36
- Publications: 160
- Citations: 4,020
Selected Publications
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ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice (2026)
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Myonuclear Dynamics After Skeletal Muscle Surgical Injury (2026)
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Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a preclinical model of colorectal cancer by biological sex (2026)
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Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations (2026)
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Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia (2026)
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Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations (2026)
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Myonuclear Dynamics After Skeletal Muscle Surgical Injury (2026)
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Targeting collagen cross-linking to support aged muscle hypertrophy (2026)
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Resident myonuclear adaptations to mechanical overload in single muscle fibers of HSA-GFP mice (2026)
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Progressive Weighted Wheel Running Enhances Neuromuscular Junction Innervation and Muscle Power in Aged Mice (2026)
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TRAIL: A potential new biomarker for muscle health in anorexia nervosa (2026)
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Assessing the role of cellular senescence on skeletal muscle fiber type-specific atrophy in older adults (2026)
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Identifying quiescent satellite cells: a scoping review of transcriptomic markers and limitations (2026)
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Ribosome dynamics during skeletal muscle repair and regeneration in mice and humans (2026)
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Myonuclear Dynamics After Skeletal Muscle Surgical Resection Injury (2026)Journal of the Arkansas Academy of Science OpenAlex
Federal Grants 3 $903,946 total
NIH
Contact PI
Jun 2025 - Jul 2030
NIH
Contact PI
Aug 2023 - Apr 2028
NIH
Contact PI
Aug 2019 - Jul 2025
Myonuclear Epigenetics of Skeletal Muscle Mass Regulation with Age
Collaboration Network
Top Collaborators
Yuan Wen
University of Kentucky (US)
16 shared publications
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise
Showing 5 of 16 shared publications
Nicholas P. Greene
University of Arkansas at Fayetteville
14 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Showing 5 of 14 shared publications
Christopher S. Fry
University of Kentucky (US)
13 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
Showing 5 of 13 shared publications
John J. McCarthy
University of Kentucky (US)
12 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- The myonuclear domain in adult skeletal muscle fibres: past, present and future
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
Showing 5 of 12 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
12 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
Showing 5 of 12 shared publications
Cory M. Dungan
Baylor University (US)
10 shared publications
- Late‐life exercise mitigates skeletal muscle epigenetic aging
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise
Showing 5 of 10 shared publications
Ferdinand von Walden
Karolinska Institutet (SE)
10 shared publications
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle
- Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Skeletal muscle hypertrophy: cell growth is cell growth
Showing 5 of 10 shared publications
Ronald G. Jones
University of Arkansas at Fayetteville
9 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
- Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia
Showing 5 of 9 shared publications
Nicholas T. Thomas
University of Kentucky (US)
8 shared publications
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy
- Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
Showing 5 of 8 shared publications
Sabin Khadgi
University of Arkansas at Fayetteville
8 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
- Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle
Showing 5 of 8 shared publications
Pieter J. Koopmans
University of Arkansas at Fayetteville
8 shared publications
In database
- The roles of miRNAs in adult skeletal muscle satellite cells
- Going nuclear: Molecular adaptations to exercise mediated by myonuclei
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16
- The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates <i>MYC</i> as a Hypertrophic Regulator That is Sufficient for Growth
Showing 5 of 8 shared publications
Charlotte A. Peterson
University of Kentucky (US)
7 shared publications
- Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- Senolytic treatment rescues blunted muscle hypertrophy in old mice
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
- Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus
Showing 5 of 7 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
7 shared publications
In database
- Exercise Counteracts the Deleterious Effects of Cancer Cachexia
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Showing 5 of 7 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
6 shared publications
In database
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Transcriptional analysis of cancer cachexia: conserved and unique features across preclinical models and biological sex
- Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
- Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females
Showing 5 of 6 shared publications
Ahmed Ismaeel
University of Kentucky (US)
6 shared publications
- Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
- The roles of miRNAs in adult skeletal muscle satellite cells
- Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus
- Skeletal muscle hypertrophy: cell growth is cell growth
- microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
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