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Listed
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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-06
O
Oxana P. Lazarenko
High Impact
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Also affiliated: United States Department of Agriculture (2011); University of Arkansas Medical Center (2024); Arkansas Children's Nutrition Center (2008–2025); Arkansas Children's Research Institute (2008); California State University, Long Beach (2012)
24 h-index
68 pubs
2,014 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Oxana P. Lazarenko's research focuses on the biological mechanisms underlying bone metabolism and development, with a particular emphasis on the role of specific genes, cellular processes, and dietary factors in regulating bone density and preventing bone loss. Her work investigates how factors such as G-protein coupled receptor 109A (GPR109A), Nox4 expression in osteo-progenitors, and epigenetic modifications like H3K27me3 and H3K27ac influence osteoclastogenesis and osteoblastogenesis.
Her recent publications explore these areas through studies in mouse models, examining the impact of genetic modifications (e.g., Ezh2 myeloid cell conditional knockout, GPR109A gene deletion) and environmental factors (e.g., maternal high-fat diet, short-term increased physical activity during early life). Lazarenko also studies the effects of compounds like hippuric acid and phenolic acids on bone health, and has contributed to a longitudinal observational study on skeletal development in children with different feeding regimens. Her scholarship metrics include an h-index of 24, 66 total publications, and 1,966 total citations, designating her as a highly cited researcher. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Jin‐Ran Chen, Michael L. Blackburn, Perry C. Caviness, and Umesh D. Wankhade.
Metrics
- h-index: 24
- Publications: 68
- Citations: 2,014
Selected Publications
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A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence (2026)
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A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence (2026)
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Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)
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Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025)
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Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)
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Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)
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Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)
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Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)
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A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)
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Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022)
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Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022)
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GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice (2022)
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Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice (2021)
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Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice (2021)
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GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice (2021)
Collaboration Network
Top Collaborators
Jin‐Ran Chen
Arkansas Children's Nutrition Center
47 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 47 shared publications
Michael L. Blackburn
Arkansas Children's Nutrition Center
30 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 30 shared publications
Thomas M. Badger
Arkansas Children's Nutrition Center
25 shared publications
In database
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 25 shared publications
Martin J. J. Ronis
Louisiana Cancer Research Center (US)
24 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
Showing 5 of 24 shared publications
Kartik Shankar
Arkansas Children's Nutrition Center (US)
16 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Inhibition of fetal bone development through epigenetic down‐regulation of HoxA10 in obese rats fed high‐fat diet
- Maternal obesity impairs skeletal development in adult offspring
Showing 5 of 16 shared publications
Jennifer F. Chen
Arkansas Children's Nutrition Center
8 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Showing 5 of 8 shared publications
Haijun Zhao
Arkansas Children's Nutrition Center (US)
6 shared publications
- Maternal obesity impairs skeletal development in adult offspring
- Hippuric acid and 3‐(3‐hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL‐RANK independent pathway
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal regulation of SATB2 in osteo‐progeniters impairs skeletal development in offspring
- Nox4 Expression Is Not Required for OVX ‐Induced Osteoblast Senescence and Bone Loss in Mice
Showing 5 of 6 shared publications
Umesh D. Wankhade
Arkansas Children's Nutrition Center
6 shared publications
In database
- Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- 3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice
- Nox4 Expression Is Not Required for OVX ‐Induced Osteoblast Senescence and Bone Loss in Mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Showing 5 of 6 shared publications
Perry C. Caviness
Arkansas Children's Nutrition Center
6 shared publications
In database
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Showing 5 of 6 shared publications
Dongzheng Gai
Winthrop Rockefeller Foundation
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Fenghuang Zhan
Winthrop Rockefeller Foundation
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Jian Zhang
Arkansas Children's Nutrition Center (US)
4 shared publications
- Feeding Blueberry Diets in Early Life Prevent Senescence of Osteoblasts and Bone Loss in Ovariectomized Adult Female Rats
- Feeding Blueberry Diets to Young Rats Dose-Dependently Inhibits Bone Resorption through Suppression of RANKL in Stromal Cells
- Feeding Blueberry Diets Dose‐Dependently Inhibits Bone Resorption in Young Rats
- Persistent Effects of a Soy Diet in Early Development on Bone in Female Rats
Xianli Wu
Arkansas Children's Nutrition Center (US)
4 shared publications
- Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
- Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
- Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat
- Lowbush blueberries inhibit scavenger receptors CD36 and SR-A expression and attenuate foam cell formation in ApoE-deficient mice
Eugénia Carvalho
Arkansas Children's Nutrition Center (US)
3 shared publications
- Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice
- Increased Physical Activity During Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice
- Increased Physical Activity Ameliorates High Fat Diet‐Induced Bone Resorption in Mice
Elisabet Børsheim
Arkansas Children's Nutrition Center
3 shared publications
In database
- Short‐Term Increased Physical Activity During Early Life Affects High‐Fat Diet–Induced Bone Loss in Young Adult Mice
- Increased Physical Activity During Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice
- Increased Physical Activity Ameliorates High Fat Diet‐Induced Bone Resorption in Mice
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