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Biography and Research Information
OverviewAI-generated summary
Oxana P. Lazarenko's research focuses on the biological mechanisms underlying bone metabolism and development, with a particular emphasis on the role of specific genes, cellular processes, and dietary factors in regulating bone density and preventing bone loss. Her work investigates how factors such as G-protein coupled receptor 109A (GPR109A), Nox4 expression in osteo-progenitors, and epigenetic modifications like H3K27me3 and H3K27ac influence osteoclastogenesis and osteoblastogenesis.
Her recent publications explore these areas through studies in mouse models, examining the impact of genetic modifications (e.g., Ezh2 myeloid cell conditional knockout, GPR109A gene deletion) and environmental factors (e.g., maternal high-fat diet, short-term increased physical activity during early life). Lazarenko also studies the effects of compounds like hippuric acid and phenolic acids on bone health, and has contributed to a longitudinal observational study on skeletal development in children with different feeding regimens. Her scholarship metrics include an h-index of 24, 66 total publications, and 1,966 total citations, designating her as a highly cited researcher. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Jin‐Ran Chen, Michael L. Blackburn, Perry C. Caviness, and Umesh D. Wankhade.
Metrics
- h-index: 24
- Publications: 66
- Citations: 1,980
Selected Publications
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A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence (2026)
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Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)
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Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025)
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Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)
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Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)
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Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)
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Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)
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A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)
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Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022)
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Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022)
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GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice (2022)
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<scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice (2021)
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Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice (2021)
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GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice (2021)
Collaboration Network
Top Collaborators
Jin‐Ran Chen
Arkansas Children's Nutrition Center
18 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
Showing 5 of 18 shared publications
Michael L. Blackburn
Arkansas Children's Nutrition Center
14 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice
Showing 5 of 14 shared publications
Perry C. Caviness
Arkansas Children's Nutrition Center
8 shared publications
In database
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Showing 5 of 8 shared publications
Umesh D. Wankhade
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Dongzheng Gai
Winthrop Rockefeller Foundation
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
Kartik Shankar
5 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Fenghuang Zhan
Winthrop Rockefeller Foundation (US)
5 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Jennifer F. Chen
Arkansas Children's Nutrition Center
4 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Beau Belcher
Arkansas Children's Nutrition Center (US)
4 shared publications
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Soy Isoflavones Prevent Loss of Bone Quality Associated With High Fat Diet in Rats Through Ameliorating Epigenetic Modifications in Bone
Haijun Zhao
Shandong University of Traditional Chinese Medicine (CN)
3 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Christopher E. Randolph
Arkansas Children's Hospital
3 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Perry Caviness
Arkansas Children's Nutrition Center (US)
3 shared publications
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
- Tissue Specific Delivery of Dietary Metabolite Phenolic Acids Using Clostridial Collagenase Collagen Binding Domain
- Soy Isoflavones Prevent Loss of Bone Quality Associated With High Fat Diet in Rats Through Ameliorating Epigenetic Modifications in Bone
Can Li
University of Arkansas for Medical Sciences (US)
2 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
Eugénia Carvalho
2 shared publications
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
Elisabet Børsheim
2 shared publications
In database
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
- Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
Similar Researchers
Based on overlapping research topics
Michael L. Blackburn
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
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Jin‐Ran Chen
University of Arkansas at Fayetteville
Bone Metabolism and Diseases
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Perry C. Caviness
University of Arkansas for Medical Sciences
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Neha S. Dole
University of Arkansas for Medical Sciences
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Vivek Khanal
University of Arkansas for Medical Sciences
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Jennifer F. Chen
University of Arkansas at Fayetteville
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