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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
O
Oxana P. Lazarenko
High Impact
Researcher
Also affiliated: Arkansas Children's Hospital (2008–2024); Stephens College (2007); University of Applied Management Studies (2024); Institute on Aging (2005); Arkansas Children's Nutrition Center (2008–2025); Arkansas Department of Agriculture (2021); California State University, Long Beach (2012)
Faculty Researcher
24 h-index
66 pubs
2,005 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Oxana P. Lazarenko's research focuses on the biological mechanisms underlying bone metabolism and development, with a particular emphasis on the role of specific genes, cellular processes, and dietary factors in regulating bone density and preventing bone loss. Her work investigates how factors such as G-protein coupled receptor 109A (GPR109A), Nox4 expression in osteo-progenitors, and epigenetic modifications like H3K27me3 and H3K27ac influence osteoclastogenesis and osteoblastogenesis.
Her recent publications explore these areas through studies in mouse models, examining the impact of genetic modifications (e.g., Ezh2 myeloid cell conditional knockout, GPR109A gene deletion) and environmental factors (e.g., maternal high-fat diet, short-term increased physical activity during early life). Lazarenko also studies the effects of compounds like hippuric acid and phenolic acids on bone health, and has contributed to a longitudinal observational study on skeletal development in children with different feeding regimens. Her scholarship metrics include an h-index of 24, 66 total publications, and 1,966 total citations, designating her as a highly cited researcher. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Jin‐Ran Chen, Michael L. Blackburn, Perry C. Caviness, and Umesh D. Wankhade.
Metrics
- h-index: 24
- Publications: 66
- Citations: 2,005
Selected Publications
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A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence (2026)
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Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025)
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Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025)
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Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025)
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Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024)
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Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024)
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Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023)
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A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023)
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Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022)
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Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022)
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GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice (2022)
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<scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice (2021)
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Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice (2021)
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GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice (2021)
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<scp>Nox4</scp> Expression Is Not Required for <scp>OVX</scp> ‐Induced Osteoblast Senescence and Bone Loss in Mice (2020)
Collaboration Network
Top Collaborators
Jin‐Ran Chen
Arkansas Children's Nutrition Center
13 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
Showing 5 of 13 shared publications
Michael L. Blackburn
Arkansas Children's Nutrition Center
11 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice
Showing 5 of 11 shared publications
Perry C. Caviness
Arkansas Children's Nutrition Center
6 shared publications
In database
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Showing 5 of 6 shared publications
Dongzheng Gai
Winthrop Rockefeller Foundation
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
Fenghuang Zhan
Winthrop Rockefeller Foundation
5 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Jennifer F. Chen
Arkansas Children's Nutrition Center
4 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Umesh D. Wankhade
Arkansas Children's Nutrition Center
3 shared publications
In database
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
Kartik Shankar
University of Colorado Denver (US)
3 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
Christopher E. Randolph
Arkansas Children's Hospital
3 shared publications
In database
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
Haijun Zhao
University of Arkansas for Medical Sciences (US)
2 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Can Li
University of Arkansas for Medical Sciences (US)
2 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice
Jovanny Zabaleta
Arkansas Children's Hospital (US)
2 shared publications
- Nox4 expression in osteo-progenitors controls bone development in mice during early life
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice
Beau Belcher
Arkansas Children's Nutrition Center (US)
2 shared publications
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications
Zijun Zhang
Arkansas Children's Hospital
2 shared publications
In database
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
Fumou Sun
Winthrop Rockefeller Foundation
2 shared publications
In database
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx
Similar Researchers
Based on overlapping research topics
Michael L. Blackburn
University of Arkansas for Medical Sciences
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Jin‐Ran Chen
University of Arkansas at Fayetteville
Bone Metabolism and Diseases
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Perry C. Caviness
University of Arkansas for Medical Sciences
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Vivek Khanal
University of Arkansas for Medical Sciences
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