Biography and Research Information
OverviewAI-generated summary
Noemi Garcia Garcia investigates the molecular mechanisms underlying cancer development and potential therapeutic targets. Her research has focused on understanding the role of specific proteins, such as Rearranged during Transfection (RET) and Tropomyosin receptor kinase A (TRKA), in cancer progression. Garcia has explored the development of small-molecule inhibitors, including indole derivatives, designed to target these proteins and impede tumor growth, with a particular emphasis on lung and breast cancers.
Her work also examines the regulation of cell invasion and migration in lung cancer, investigating novel regulators like Rnd3. This research aims to define how these factors influence the metastatic potential of cancer cells, contributing to the broader understanding of cancer cell behavior and the identification of new therapeutic strategies. Garcia collaborates with researchers at the University of Arkansas for Medical Sciences, including Katie R. Ryan and Brendan Frett.
Metrics
- h-index: 2
- Publications: 5
- Citations: 40
Selected Publications
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Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation (2026)
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Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner (2025)
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Abstract 2649: Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of triple-negative breast cancer (2025)
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Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors (2024)
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Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development (2021)
Collaboration Network
Top Collaborators
Katie R. Ryan
University of Arkansas for Medical Sciences
5 shared publications
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
- Abstract 2649: Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of triple-negative breast cancer
- Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner
- Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation
Dane Richey
University of Arkansas for Medical Sciences
3 shared publications
In database
- Abstract 2649: Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of triple-negative breast cancer
- Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner
- Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation
Debasmita Saha
Discovery Institute (US)
2 shared publications
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Baku Acharya
University of Arkansas for Medical Sciences
2 shared publications
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Brendan Frett
University of Arkansas for Medical Sciences
2 shared publications
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Thuy Thi Nguyen
University of Arkansas for Medical Sciences
2 shared publications
In database
- Abstract 2649: Defining how Rnd3, a novel regulator of breast cancer invasion, affects the metastatic potential of triple-negative breast cancer
- Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner
Naga Rajiv Lakkaniga
University of Arkansas for Medical Sciences (US)
1 shared publication
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
Erica Lane Smith
University of Arkansas for Medical Sciences
1 shared publication
In database
- Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development
Daniel W. Armstrong
University of Arkansas for Medical Sciences
1 shared publication
In database
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Baha’a Jabali
University of Arkansas for Medical Sciences
1 shared publication
In database
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Maha Hanafi
Cairo University (EG)
1 shared publication
- Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors
Cody Ashby
University of Arkansas for Medical Sciences
1 shared publication
In database
- Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner
Analiz Rodriguez
University of Arkansas for Medical Sciences
1 shared publication
In database
- Abstract 2645: Rnd3 depletion in lung cancer cell lines decreases cell invasion and migration in a ROCK1 independent manner
Thanh Ha Vy Nguyen
University of Arkansas for Medical Sciences (US)
1 shared publication
- Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation
Emily F Cox
University of Arkansas for Medical Sciences (US)
1 shared publication
- Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation
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