Baku Acharya

Researcher

University of Arkansas for Medical Sciences

faculty

8 h-index 90 pubs 185 cited

Research Areas

Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Drug-Induced Hepatotoxicity and Protection Computational Drug Discovery Methods Cancer Cells and Metastasis Pharmacological Effects and Toxicity Studies Synthesis and biological activity

Links

ORCID Lab Website Research Group

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OverviewAI-generated summary

Baku Acharya's research focuses on the development of small-molecule inhibitors for various cancer-related targets. His work has investigated the potential of targeting rearranged during transfection (RET) kinase in cancers, including a patent review of RET kinase inhibitors. Acharya has also explored bifunctional inhibitors targeting NEK2 in lymphoma and novel G-quadruplex structures in oncogenes. His publications include the discovery of compounds that inhibit RET/TRKA dual targets and DNA-PKcs, with an emphasis on improving compound solubility. Acharya has a significant publication record with 90 total publications and 185 citations, and an h-index of 8. He has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Ying-Zhi Xu, Mason McCrury, Kennith Swafford, and Brendan Frett, with whom he shares numerous publications.

Metrics

  • h-index: 8
  • Publications: 90
  • Citations: 185

Selected Publications

  • Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441 (2024) DOI
  • Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors (2024) DOI
  • Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules (2023) DOI
  • An updated patent review of rearranged during transfection (RET) kinase inhibitors (2016–present) (2022) DOI
  • FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms (2022) DOI
  • Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group (2022) DOI
  • Targeting TGF-β: Triumphs and Challenges (2022) DOI
  • Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development (2021) DOI

Collaborators

Researchers in the database who share publications

Ying-Zhi Xu University of Arkansas for Medical Sciences 42 shared publications Mason McCrury University of Arkansas for Medical Sciences 42 shared publications Kennith Swafford University of Arkansas for Medical Sciences 42 shared publications Brendan Frett University of Arkansas for Medical Sciences 41 shared publications Vijay Patel University of Arkansas for Medical Sciences 41 shared publications Sydnye L. Shuttleworth University of Arkansas for Medical Sciences 41 shared publications Samantha Kendrick University of Arkansas for Medical Sciences 41 shared publications Annick De Loose University of Arkansas for Medical Sciences 41 shared publications

Similar Researchers

Based on overlapping research topics

Brendan Frett University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Drug-Induced Hepatotoxicity and Protection
Good match 5 shared topics
Baha’a Jabali University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Drug-Induced Hepatotoxicity and Protection
Good match 4 shared topics
Subrata Roy Arkansas State University
Cancer Treatment and Pharmacology Drug-Induced Hepatotoxicity and Protection Computational Drug Discovery Methods
Good match 5 shared topics
Sanjay Adhikary University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
Anupreet Kharbanda University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Computational Drug Discovery Methods
Good match 4 shared topics
Fengping Lv University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Cancer-related molecular mechanisms research Pharmacological Effects and Toxicity Studies
Good match 4 shared topics