P
Paul C. Howard Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
faculty
49 h-index
204 pubs
7,511 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Paul C. Howard's research focuses on toxicological studies, particularly involving inhalation exposure and the pharmacokinetic analysis of various compounds in Sprague-Dawley rats. His work has investigated the toxicokinetic and genotoxicity of NNK, a compound relevant to tobacco-related cancers, through different exposure routes including nose-only inhalation, intraperitoneal injection, and oral gavage. He has also conducted pharmacokinetic analyses of nicotine and its metabolites following various administration methods.
Beyond specific compound toxicology, Howard has contributed to broader discussions in drug development and rare disease research, advocating for data sharing and the advancement of alternative methods to reduce animal testing. His research interests also extend to public health, as evidenced by his publication on COVID-19 pandemic-related concerns in young people with autoimmune rheumatic diseases. Howard's scholarship metrics include an h-index of 49, with over 200 publications and 7,500 citations, designating him as a highly cited researcher. He has collaborated extensively with colleagues at the National Center for Toxicological Research, including Matthew Bryant, Sherry M. Lewis, Shu-Chieh Hu, and Hyun-Ki Kang, with whom he shares multiple publications.
Metrics
- h-index: 49
- Publications: 204
- Citations: 7,511
Selected Publications
-
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
-
90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)
-
14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)
-
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
Collaboration Network
Top Collaborators
Shu-Chieh Hu
National Center for Toxicological Research
4 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Matthew Bryant
United States Food and Drug Administration
4 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Estatira Sepehr
National Center for Toxicological Research (US)
4 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Hyun-Ki Kang
United States Food and Drug Administration
4 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Sherry M. Lewis
National Center for Toxicological Research
4 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Susan Chemerynski
Japan Tobacco (United States) (US)
4 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Steven B. Yee
Japan Tobacco (United States) (US)
4 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Hans Rosenfeldt
Japan Tobacco (United States) (US)
4 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
R Philip Yeager
Japan Tobacco (United States) (US)
4 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Yunan Tang
United States Food and Drug Administration (US)
4 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Nathan Denton
University of Pennsylvania (US)
3 shared publications
- Data silos are undermining drug development and failing rare disease patients
- Sharing is caring: a call for a new era of rare disease research and development
- Correction to: Sharing is caring: a call for a new era of rare disease research and development
Monique Molloy
University of Pennsylvania (US)
3 shared publications
- Data silos are undermining drug development and failing rare disease patients
- Sharing is caring: a call for a new era of rare disease research and development
- Correction to: Sharing is caring: a call for a new era of rare disease research and development
Samantha Charleston
University of Pennsylvania (US)
3 shared publications
- Data silos are undermining drug development and failing rare disease patients
- Sharing is caring: a call for a new era of rare disease research and development
- Correction to: Sharing is caring: a call for a new era of rare disease research and development
Andrew E. Mulberg
3 shared publications
- Data silos are undermining drug development and failing rare disease patients
- Sharing is caring: a call for a new era of rare disease research and development
- Correction to: Sharing is caring: a call for a new era of rare disease research and development
Eric D. Marsh
University of Pennsylvania (US)
3 shared publications
- Data silos are undermining drug development and failing rare disease patients
- Sharing is caring: a call for a new era of rare disease research and development
- Correction to: Sharing is caring: a call for a new era of rare disease research and development
Similar Researchers
Based on overlapping research topics
Shu-Chieh Hu
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Joseph G. Shaddock
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Matthew Bryant
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Roberta A. Mittelstaedt
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Hyun-Ki Kang
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Mason G. Pearce
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders