Paul C. Howard

This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.

High Impact

Researcher

NCTR

Formerly Arkansas Affiliated with NCTR, UAMS through 2024; recent publications list Isle of Wight NHS Trust.

Faculty Researcher

49 h-index 204 pubs 7,511 cited

Research Areas

Biomedical Subjects

OverviewAI-generated summary

Paul C. Howard's research focuses on toxicological studies, particularly involving chemical exposures in animal models. He has conducted extensive studies on the toxicokinetics and genotoxicity of NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone), a known carcinogen, in Sprague-Dawley rats. These investigations have examined various routes of exposure, including nose-only inhalation, intraperitoneal injection, and oral gavage, and have assessed both short-term (14-day) and longer-term (90-day) toxicity. His work also includes pharmacokinetic analyses of nicotine and its metabolites in rats, investigating their absorption, distribution, metabolism, and excretion following different administration methods.

In addition to direct toxicological assessments, Howard has contributed to discussions on broader research practices. He has published on the challenges posed by data silos in drug development, particularly for rare diseases, and has advocated for increased data sharing to accelerate research and development in this area. He has also contributed to the discourse on advancing alternative methods to reduce animal testing, reflecting a commitment to ethical considerations in scientific research. His scholarly contributions are evidenced by a significant publication record and a high citation count, designating him as a highly cited researcher.

Metrics

h-index: 49
Publications: 204
Citations: 7,511

Selected Publications

Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)

Toxicological Sciences 8 citations DOI OpenAlex
90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)

Food and Chemical Toxicology 6 citations DOI OpenAlex
14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)

Toxicological Sciences 7 citations DOI OpenAlex
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)

Toxicological Sciences 15 citations DOI OpenAlex
Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements (2018)

Food and Chemical Toxicology 27 citations DOI OpenAlex
Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment (2018)

Experimental Cell Research 39 citations DOI OpenAlex
Microbiological survey of commercial tattoo and permanent makeup inks available in the United States (2018)

Journal of Applied Microbiology 26 citations DOI OpenAlex
Investigating the Susceptibility of Mice to a Bacterial Challenge After Intravenous Exposure to Durable Nanoparticles (2017)

Nanomedicine 2 citations DOI OpenAlex
Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions (2017)

Particle and Fibre Toxicology 48 citations DOI OpenAlex
Photo‐co‐carcinogenesis of Topically Applied Retinyl Palmitate in SKH‐1 Hairless Mice (2017)

Photochemistry and Photobiology 4 citations DOI OpenAlex
FDA drug labeling: rich resources to facilitate precision medicine, drug safety, and regulatory science (2016)

Drug Discovery Today 56 citations DOI OpenAlex
Repetitive Application of Sunscreen Containing Titanium Dioxide Nanoparticles on Human Skin (2016)

JAMA Dermatology 28 citations DOI OpenAlex
Serial Block Face-Scanning Electron Microscopy of the Developing Rat Brain Exposed to Ketamine Reveals Changes in Mitochondrial Ultrastructure (2015)

Microscopy and Microanalysis 1 citation DOI OpenAlex
Detection and Characterization of SiO2 and TiO2 Nanostructures in Dietary Supplements (2015)

Journal of Agricultural and Food Chemistry 64 citations DOI OpenAlex
Effects of iron oxide nanoparticles on biological responses and <scp>MR</scp> imaging properties in human mammary healthy and breast cancer epithelial cells (2015)

Journal of Biomedical Materials Research Part B Applied Biomaterials 17 citations DOI OpenAlex