Biography and Research Information
OverviewAI-generated summary
Sharda P. Singh's research investigates the role of oxidative stress and mitochondrial dysfunction in neurodegenerative diseases, particularly Alzheimer's disease. Her work has explored the function of RALBP1 (RLIP76) in these processes, utilizing autopsy brains from Alzheimer's patients and immortalized hippocampal neurons. Singh also examines the impact of oxidative stress on other conditions, including skin aging and breast cancer, and has investigated potential therapeutic interventions such as dietary supplementation with sulforaphane and iron chelation.
Her publications include studies on the Keap1-Nrf2 pathway in skin aging and the anticancer activity of omega-6 fatty acids. Singh's recent work also addresses age-related skeletal muscle sarcopenia in mice, employing iron chelation as a preventative measure. With an h-index of 25 and over 2,500 citations from more than 110 publications, she is recognized as a highly cited researcher. Singh collaborates with several researchers at the University of Arkansas for Medical Sciences, including Chhanda Bose, Philip Palade, Elisabet Børsheim, and Ashley Nemec-Bakk.
Metrics
- h-index: 25
- Publications: 110
- Citations: 2,600
Selected Publications
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Iron Chelation Prevents Age‐Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging (2025)
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Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway (2021)
Collaboration Network
Top Collaborators
Chhanda Bose
Texas Tech University Health Sciences Center
19 shared publications
In database
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
- The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients
- Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
Showing 5 of 19 shared publications
Ashly Hindle
Texas Tech University Health Sciences Center (US)
16 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
- The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients
- Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
Showing 5 of 16 shared publications
Sanjay Awasthi
10 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
Showing 5 of 10 shared publications
P. Hemachandra Reddy
Texas Tech University (US)
10 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
- The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients
- Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
- Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights
Showing 5 of 10 shared publications
Rakhshanda Layeequr Rahman
MetroHealth Medical Center (US)
8 shared publications
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Leveraging cryoablation and checkpoint inhibitors for high-risk triple negative breast cancer
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
Showing 5 of 8 shared publications
Sudhir Kshirsagar
Texas Tech University (US)
8 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
- The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients
- Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
- Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights
Showing 5 of 8 shared publications
Michael W. Melkus
Texas Tech University (US)
7 shared publications
- Leveraging cryoablation and checkpoint inhibitors for high-risk triple negative breast cancer
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Abstract P3-02-09: Correlation between risk groups and molecular subtype of breast cancer with metabolic syndrome and ethnicity
Showing 5 of 7 shared publications
Philip Palade
University of Arkansas for Medical Sciences
6 shared publications
In database
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
Showing 5 of 6 shared publications
Jangampalli Adi Pradeepkiran
Texas Tech University (US)
5 shared publications
- Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
- Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
- Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights
- Corrigendum to “Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights” [Biochim. Biophys. Acta Mol. Basis Dis. 2023 Oct;1869(7):166759. doi: 10.1016/j.bbadis.2023.166759. Epub 2023 May 22. PMID: 37225106]
- Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells 2023, 12, 1646
Jonathan Kopel
4 shared publications
- Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
- Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
- Rlip Protein: A Potential Target for COVID-19
- List of contributors
Murali Vijayan
Texas Tech University (US)
4 shared publications
- RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
- Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
- The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients
- Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
Sonia Y. Khan
The University of Texas Rio Grande Valley (US)
4 shared publications
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer
- List of contributors
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
Arubala P. Reddy
Texas Tech University (US)
4 shared publications
- Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights
- Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights
- Corrigendum to “Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights” [Biochim. Biophys. Acta Mol. Basis Dis. 2023 Oct;1869(7):166759. doi: 10.1016/j.bbadis.2023.166759. Epub 2023 May 22. PMID: 37225106]
- Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells 2023, 12, 1646
Flávia Sardela de Miranda
Texas Tech University Health Sciences Center (US)
4 shared publications
- Leveraging cryoablation and checkpoint inhibitors for high-risk triple negative breast cancer
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
Rachel L. Babcock
Texas Tech University (US)
4 shared publications
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors
- Abstract P1-06-16: Tumor Immune Micro-Environment (TIME) Effect of Cryoablation in Triple-Negative Breast Cancer - It was the best of TIMES
- Combination of immune checkpoint inhibition with cryoablation augments T cell activation in the tumor immune microenvironment (TIME) - it is about TIME! 2575
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