Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Biography and Research Information
OverviewAI-generated summary
Sharda P. Singh's research investigates the role of oxidative stress and mitochondrial dysfunction in neurodegenerative diseases, particularly Alzheimer's disease. Her work has explored the function of RALBP1 (RLIP76) in these processes, utilizing autopsy brains from Alzheimer's patients and immortalized hippocampal neurons. Singh also examines the impact of oxidative stress on other conditions, including skin aging and breast cancer, and has investigated potential therapeutic interventions such as dietary supplementation with sulforaphane and iron chelation.
Her publications include studies on the Keap1-Nrf2 pathway in skin aging and the anticancer activity of omega-6 fatty acids. Singh's recent work also addresses age-related skeletal muscle sarcopenia in mice, employing iron chelation as a preventative measure. With an h-index of 25 and over 2,500 citations from more than 110 publications, she is recognized as a highly cited researcher. Singh collaborates with several researchers at the University of Arkansas for Medical Sciences, including Chhanda Bose, Philip Palade, Elisabet Børsheim, and Ashley Nemec-Bakk.
Metrics
- h-index: 25
- Publications: 110
- Citations: 2,600
Positions
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Associate professor 2017–presentTTUHSC Internal medicine ORCID
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Associate professorUniversity of Arkansas for Medical Sciences ORCID
Selected Publications
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Iron Chelation Prevents Age‐Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging (2025)
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Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway (2021)
Collaboration Network
Top Collaborators
Piotr Zimniak
Central Arkansas Veterans Healthcare System (US)
11 shared publications
- Catalytic function of Drosophila melanogaster glutathione S ‐transferase DmGSTS1‐1 (GST‐2) in conjugation of lipid peroxidation end products
- Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class
- Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells
- Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice
- Membrane Association of Glutathione S-Transferase mGSTA4-4, an Enzyme That Metabolizes Lipid Peroxidation Products
Showing 5 of 11 shared publications
Sanjay Awasthi
Texas Tech University (US)
11 shared publications
- Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling
- Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice
- Membrane Association of Glutathione S-Transferase mGSTA4-4, an Enzyme That Metabolizes Lipid Peroxidation Products
- Membrane Association of Glutathione S-Transferase mGSTA4-4, an Enzyme That Metabolizes Lipid Peroxidation Products
Showing 5 of 11 shared publications
Helen Beneš
University of Arkansas for Medical Sciences (US)
5 shared publications
- Catalytic function of Drosophila melanogaster glutathione S ‐transferase DmGSTS1‐1 (GST‐2) in conjugation of lipid peroxidation end products
- Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class
- Sulforaphane protects the heart from doxorubicin-induced toxicity
- Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- Protection from Oxidative and Electrophilic Stress in the Gsta4-null Mouse Heart
Marjan Boerma
University of Arkansas for Medical Sciences
4 shared publications
In database
- Effects of ionizing radiation on the heart
- Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart
- Protection from Oxidative and Electrophilic Stress in the Gsta4-null Mouse Heart
Clark Sims
University of Arkansas for Medical Sciences
3 shared publications
In database
- Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome
- Preclinical Evaluation of the Phosphodiesterase‐4 Inhibitor, Rolipram, in an Infant Model of Sepsis‐Induced Cardiorenal Syndrome
- Targeting mitochondrial oxidants in a pediatric model of sepsis‐induced cardiomyopathy
Preeti Singh
Central Arkansas Veterans Healthcare System (US)
3 shared publications
- Sulforaphane protects the heart from doxorubicin-induced toxicity
- Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
- Targeting mitochondrial oxidants in a pediatric model of sepsis‐induced cardiomyopathy
Ludwika Zimniak
University of North Texas (US)
3 shared publications
- Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice
- Fat accumulation in Caenorhabditis elegans triggeredby the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE)
- The human hGSTA5 gene encodes an enzymatically active protein
Rajendra Sharma
University of Arkansas for Medical Sciences (US)
3 shared publications
- Sulforaphane protects the heart from doxorubicin-induced toxicity
- Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- Transfection with 4‐hydroxynonenal‐metabolizing glutathione S‐transferase isozymes leads to phenotypic transformation and immortalization of adherent cells
Chhanda Bose
Central Arkansas Veterans Healthcare System
3 shared publications
In database
- Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- A New Derivatization Reagent for HPLC–MS Analysis of Biological Organic Acids
- Iron Chelation Prevents Age‐Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging
Maciej Niemczyk
University of North Texas (US)
2 shared publications
- Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice
- Fat accumulation in Caenorhabditis elegans triggeredby the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE)
Sharad S. Singhal
The University of Texas at Arlington (US)
2 shared publications
- Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling
- Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues
Shivendra V. Singh
Central Arkansas Veterans Healthcare System (US)
2 shared publications
- Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells
- Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues
Yusong Yang
The University of Texas Medical Branch at Galveston (US)
2 shared publications
- Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues
- Transfection with 4‐hydroxynonenal‐metabolizing glutathione S‐transferase isozymes leads to phenotypic transformation and immortalization of adherent cells
Kevin E. McElhanon
Central Arkansas Veterans Healthcare System (US)
2 shared publications
- Sulforaphane protects the heart from doxorubicin-induced toxicity
- Protection from Oxidative and Electrophilic Stress in the Gsta4-null Mouse Heart
Vijayalakshmi Sridharan
University of Arkansas for Medical Sciences
2 shared publications
In database
- Effects of ionizing radiation on the heart
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart
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