Sree V. Chintapalli
Assistant Professor (non-tenure)
faculty
Research Areas
Biography and Research Information
OverviewAI-generated summary
Sree V. Chintapalli's research focuses on the interplay between diet, the gut microbiome, and host physiology, particularly in the context of metabolic health and disease. Dr. Chintapalli investigates how maternal diet and obesity influence the offspring's gut microbiome composition and function during early life. This work explores the potential for dietary interventions, such as the inclusion of blueberries and strawberries, to ameliorate vascular complications and metabolic syndrome in mouse models. The research also examines sex differences in skeletal muscle characteristics and the molecular mechanisms underlying bone metabolism, including the role of specific metabolites like hippuric acid.
Further research by Dr. Chintapalli delves into the diverse functions of myoglobin, exploring its potential roles beyond oxygen transport, including in brown adipose tissue. This line of inquiry utilizes myoglobin knockout mice to understand these novel functions. Collaborating with researchers at the University of Arkansas for Medical Sciences, including Sean H. Adams, Umesh D. Wankhade, Brian D. Piccolo, and Aline Andres, Dr. Chintapalli's work contributes to a broader understanding of metabolic and physiological processes. With 95 publications and an h-index of 25, Dr. Chintapalli is recognized as a highly cited researcher.
Metrics
- h-index: 25
- Publications: 98
- Citations: 1,869
Selected Publications
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Enhancing Mitochondrial Function in Skeletal Muscle Cells through Metabolite Modulation: Therapeutic Implications for Muscle Metabolic Diseases (2025)
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Abstract 1547 Innovative Insights into Myoglobin-Metabolite Interactions and Muscle Cell Bioenergetics (2025)
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The Effect of Mhealth Interventions on Quality of Life in HIV Patients: A GRADE Assessed Systematic Review and Meta-Analysis (2025)
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Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery (2025)
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Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice (2024)
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Unraveling Protein-Metabolite Interactions in Precision Nutrition: A Case Study of Blueberry-Derived Metabolites Using Advanced Computational Methods (2024)
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Quantitative Metabolomics-Driven Protein Target Prediction: A Computational Workflow for Precision Nutrition Discovery (2024)
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Effect of lactate supplementation to skeletal muscle cells on fiber type transition and cellular bioenergetics (2024)
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Myoglobin: A versatile age-old oxygen carrying hemoprotein and its emerging role in metabolite regulation in diverse tissues (2024)
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A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin (2024)
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Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction (2024)
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Spinal Cord Injury-Induced Neurogenic Bowel: A Role for Host-Microbiome Interactions in Bowel Pain and Dysfunction (2024)
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Molecular insights into myoglobin binding patterns with the outer mitochondrial membrane: A comparison of oxygenated and deoxygenated states (2024)
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Metabolic and fecal microbial changes in adult fetal growth restricted mice (2023)
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Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane (2023)
Collaboration Network
Top Collaborators
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction
Showing 5 of 13 shared publications
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
- Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics
- Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy
Showing 5 of 13 shared publications
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics
- Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy
- Computational insights on molecular interactions of acifran with GPR109A and GPR109B
- Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane
Showing 5 of 12 shared publications
- Sex differences in skeletal muscle revealed through fiber type, capillarity, and transcriptomics profiling in mice
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice
Showing 5 of 11 shared publications
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin
- Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics
- Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
- Myoglobin–Pyruvate Interactions: Binding Thermodynamics, Structure–Function Relationships, and Impact on Oxygen Release Kinetics
- Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy
Showing 5 of 11 shared publications
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Showing 5 of 8 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- C‐section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying <i>Lachnoclostridium [clostridium] scindens</i> in mice
- Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice
Showing 5 of 8 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
- 271-OR: ADA Presidents’ Select Abstract: MyD88 Signaling in Trophoblasts Is Necessary for Maternal High-Fat Diet-Associated Developmental Programming of Obesity
Showing 5 of 6 shared publications
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice
- Metabolic and fecal microbial changes in adult fetal growth restricted mice
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
- Spinal cord injury-induced neurogenic bowel: A role for host-microbiome interactions in bowel pain and dysfunction
- Unraveling Protein-Metabolite Interactions in Precision Nutrition: A Case Study of Blueberry-Derived Metabolites Using Advanced Computational Methods
- Spinal Cord Injury-Induced Neurogenic Bowel: A Role for Host-Microbiome Interactions in Bowel Pain and Dysfunction
- Quantitative Metabolomics-Driven Protein Target Prediction: A Computational Workflow for Precision Nutrition Discovery
- Unlocking the Gut-Brain Connection: Targeting the Microbiome to Relieve Visceral Hypersensitivity and Restore Function in Irritable Bowel Syndrome
- Associations between maternal obesity and offspring gut microbiome in the first year of life
- Associations between Maternal Diet, Body Composition and Gut Microbial Ecology in Pregnancy
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Front Cover: Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Back Cover: Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Front Cover: Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Back Cover: Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Front Cover: Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Back Cover: Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
- Front Cover: Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
- Back Cover: Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
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