Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
S
Stepan Melnyk
High Impact
Professor
Also affiliated: Louisiana State University (1999); Arkansas Children's Hospital (1999–2024); United States Food and Drug Administration (1999–2002); NewYork–Presbyterian Brooklyn Methodist Hospital (2003); University of British Columbia (2003–2006); University of Illinois Urbana-Champaign (2002); Cornell University (2003); Saginaw Valley State University (1999); University of Tampere (2002); Arkansas Children's Research Institute (2004–2024); University of California, Davis (2002); Lviv Polytechnic National University (2013–2024)
55 h-index
140 pubs
11,039 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Stepan Melnyk's research focuses on the metabolic underpinnings of neurological and developmental disorders, with a particular emphasis on autism spectrum disorder and Down syndrome. His work investigates the interplay between methylation capacity, oxidative stress, and nutrient metabolism in these conditions. Melnyk has examined metabolic biomarkers and genetic factors associated with increased oxidative stress and impaired methylation in children diagnosed with autism.
His publications explore the link between elevated homocysteine levels and DNA hypomethylation, suggesting potential epigenetic mechanisms contributing to various pathologies. Melnyk has also investigated oxidative damage and inflammation in the context of low glutathione redox status within the autism brain. Furthermore, his research has examined the role of folate metabolism and methylenetetrahydrofolate reductase gene mutations as potential maternal risk factors for Down syndrome.
Melnyk is a highly cited researcher with a substantial publication record and a significant h-index of 55. He has collaborated with several researchers at the University of Arkansas for Medical Sciences, including Igor Koturbash, Reza Hakkak, S. Jill James, and Martin Hauer-Jensen, on multiple shared publications.
Metrics
- h-index: 55
- Publications: 140
- Citations: 11,039
Positions
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Professor publications 1999–2025University of Arkansas for Medical Sciences Institutional directory
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Professor publications 2013–2024Lviv Polytechnic National University Department of Organic Products Technology ORCID
Selected Publications
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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The association between prenatal oxidative stress levels measured by isoprostanes and offspring neurodevelopmental outcomes at 36 months (2024)
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Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression (2022)
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Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder (2021)
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Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study (2020)
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Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study (2020)
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Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study (2020)
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Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study (2020)
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Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study (2020)
Collaboration Network
Top Collaborators
S. Jill James
University of Arkansas for Medical Sciences
72 shared publications
In database
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
- Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
- Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
Showing 5 of 72 shared publications
Igor P. Pogribny
National Center for Toxicological Research
28 shared publications
In database
- Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation
- Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
- Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
- Intracellular S-Adenosylhomocysteine Concentrations Predict Global DNA Hypomethylation in Tissues of Methyl-Deficient Cystathionine β-Synthase Heterozygous Mice
- Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation
Showing 5 of 28 shared publications
Shannon Rose
Arkansas Children's Hospital
19 shared publications
In database
- Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
- Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
- Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
- Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
Showing 5 of 19 shared publications
Richard E. Frye
Arkansas Children's Hospital (US)
17 shared publications
- Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
- Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
- Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
- Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
- Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
Showing 5 of 17 shared publications
Oleksandra Pavliv
Arkansas Children's Hospital
14 shared publications
In database
- Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
- Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
- A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism
- Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
Showing 5 of 14 shared publications
Stefanie Jernigan
University of Arkansas for Medical Sciences (US)
13 shared publications
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Intracellular S-Adenosylhomocysteine Concentrations Predict Global DNA Hypomethylation in Tissues of Methyl-Deficient Cystathionine β-Synthase Heterozygous Mice
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
- Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats
Showing 5 of 13 shared publications
Marta Pogribna
National Center for Toxicological Research
11 shared publications
In database
- Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation
- Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
- Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology
- Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation
- Measurement of Plasma and Intracellular S-Adenosylmethionine and S-Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5′-Phosphate Concentrations
Showing 5 of 11 shared publications
Juergen Hahn
Rensselaer Polytechnic Institute (US)
11 shared publications
- Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation
- Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically‐developing peers: A comparison and validation study
- Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome
- Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior
- Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder
Showing 5 of 11 shared publications
Marie Tippett
Arkansas Children's Hospital
10 shared publications
In database
- Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
- Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
- Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
- Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines
- Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups
Showing 5 of 10 shared publications
David W. Gaylor
University of Arkansas for Medical Sciences
9 shared publications
In database
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
- Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
Showing 5 of 9 shared publications
Volodymyr Tryndyak
National Center for Toxicological Research
9 shared publications
In database
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Effect of methionine‐deficient and methionine‐supplemented diets on the hepatic one‐carbon and lipid metabolism in mice
- Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
Showing 5 of 9 shared publications
Leanna Delhey
Arkansas Children's Hospital
9 shared publications
In database
- Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
- Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
- Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
- Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups
- Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder
Showing 5 of 9 shared publications
Sirish C. Bennuri
Arkansas Children's Hospital (US)
9 shared publications
- Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
- Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
- Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study
- Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups
- Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder
Showing 5 of 9 shared publications
Uwe Krüger
Rensselaer Polytechnic Institute (US)
9 shared publications
- Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation
- Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome
- Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior
- Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study
- Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study
Showing 5 of 9 shared publications
Mario A. Cleves
Arkansas Children's Hospital (US)
8 shared publications
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism ,
- A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism
- Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydroflate reductase gene: Evaluating gene-environment interactions
- Congenital heart defects and maternal biomarkers of oxidative stress
Showing 5 of 8 shared publications
Similar Researchers
Based on overlapping research topics
S. Jill James
University of Arkansas for Medical Sciences
Autism Spectrum Disorder Research
Epigenetics and DNA Methylation
Metabolism and Genetic Disorders
Oleksandra Pavliv
University of Arkansas for Medical Sciences
Autism Spectrum Disorder Research
Epigenetics and DNA Methylation
Metabolism and Genetic Disorders
Shannon Rose
University of Arkansas for Medical Sciences
Autism Spectrum Disorder Research
Metabolism and Genetic Disorders
Oxidative Stress
David W. Gaylor
National Center for Toxicological Research
Autism Spectrum Disorder Research
Metabolism and Genetic Disorders
Diet and Metabolism Studies
Horacio Gómez-Acevedo
University of Arkansas for Medical Sciences
Epigenetics and DNA Methylation
Metabolism and Genetic Disorders
Diet and Metabolism Studies
Jayne B. Bellando
University of Arkansas for Medical Sciences
Autism Spectrum Disorder Research
Diet and Metabolism Studies
Child and Adolescent Health