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Listed
Presence
Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
N
Narsimha Reddy Penthala
High Impact
Instructor
Also affiliated: University of Kentucky (2008–2011); University of Arkansas Medical Center (2013–2018); Richard L. Roudebush VA Medical Center (2017); Indiana University School of Medicine (2017); University of Colorado Anschutz (2015)
Pharmaceutics, College of Pharmacy
25 h-index
158 pubs
1,447 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Narsimha Reddy Penthala's research focuses on the pharmacological investigation of novel therapeutic agents, with a particular emphasis on cancer, neurodegenerative diseases, and drug delivery systems. His work includes the synthesis and evaluation of compounds designed to inhibit tumor growth and invasion, such as sesquiterpene lactone analogs that target NFκB signaling pathways. He has also explored the potential of thiadiazolidinone (TDZD) analogs to mitigate aggregation-related pathologies in models of neurodegeneration and to extend lifespan in *C. elegans*.
Further research areas include the development of anticholinesterase therapeutics for Alzheimer's disease and the assessment of drug toxicity and pharmacokinetics. Penthala has investigated the bone and kidney toxicity of potential antibiotic carriers and conducted pharmacokinetic studies of morphine-6-O-sulfate in rat models. His research employs diverse models, including patient-derived organoids and transgenic animal models, to assess the efficacy and safety of potential treatments. He leads a research group and has a publication record of 159 articles, with an h-index of 24 and over 1,400 citations.
Metrics
- h-index: 25
- Publications: 158
- Citations: 1,447
Positions
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Instructor 2014–presentUniversity of Arkansas for Medical Sciences Pharmaceutics, College of Pharmacy Institutional directory
Selected Publications
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Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)
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Table S2 from Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer (2023)
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Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion (2021)
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Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease (2021)
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Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD) (2021)
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Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone (2021)
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A pharmacokinetic study of morphine‐6‐O ‐sulfate in rat plasma and brain (2021)
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Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs (2020)
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Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands (2020)
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7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands (2020)
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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation (2020)
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Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model (2020)
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Oxone®-Mediated TEMPO-Oxidized Cellulose Nanomaterials form I and form II (2020)
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Aggregate Interactome Based on Protein-Crosslinking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases (2019)
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A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease (2019)
Grants & Funding
As listed on this researcher's institutional profile.
- Enhancing the prevention and treatment of orthopaedic infections associated with traumatic injury US Department of Defense Co-Investigator
- Development of Small Molecule Radiation Sensitizers NIH/Nat. Cancer Institute via Vanderbilt University Co-Investigator
- Development of Novel Therapeutics for Methamphetamine Abuse - Continuation NIH/Nat. Inst. on Drug Abuse via University of Kentucky Research Foundation Co-Investigator
- Early Events in Alzheimer Pathogenesis NIH Co-Investigator
- Novel melampomagnolide B-based prodrugs for the treatment of leukemia NIH Co-Investigator
Collaboration Network
Top Collaborators
Peter A. Crooks
University of Arkansas for Medical Sciences
85 shared publications
In database
- Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents
- Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
Showing 5 of 85 shared publications
Nikhil Reddy Madadi
University of Arkansas for Medical Sciences (US)
16 shared publications
- Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines
- Anti-cancer activity of carbamate derivatives of melampomagnolide B
Showing 5 of 16 shared publications
Venumadhav Janganati
University of Arkansas for Medical Sciences (US)
16 shared publications
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines
- Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells
- Anti-cancer activity of carbamate derivatives of melampomagnolide B
- Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells
Showing 5 of 16 shared publications
Sean Parkin
University of Kentucky (US)
15 shared publications
- Comparison of crystal structures of 4-(benzo[b]thiophen-2-yl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole and 4-(benzo[b]thiophen-2-yl)-2-methyl-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole
- Crystal structure of 4,5-bis(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole methanol monosolvate
- Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl}parthenolide methanol hemisolvate
- Solvent‐Specific C―N Bond Formation: Synthesis of Novel Ninhydrin–Creatinine Heterocyclic Condensation Products
- (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
Showing 5 of 15 shared publications
Shobanbabu Bommagani
University of Arkansas for Medical Sciences
15 shared publications
In database
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- A novel tetrazole analogue of resveratrol is a potent anticancer agent
- Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells
- Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression
- Synthesis and evaluation of a series of quinolinyl trans-cyanostilbene analogs as anticancer agents
Showing 5 of 15 shared publications
Robert L. Eoff
University of Arkansas for Medical Sciences
12 shared publications
In database
- Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1)
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
Showing 5 of 12 shared publications
Amit Ketkar
University of Arkansas for Medical Sciences
10 shared publications
In database
- Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1)
- A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
- Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
Showing 5 of 10 shared publications
Meenakshisundaram Balasubramaniam
University of Arkansas for Medical Sciences
8 shared publications
In database
- Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
- A novel tetrazole analogue of resveratrol is a potent anticancer agent
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
Showing 5 of 8 shared publications
Paul L. Prather
University of Arkansas for Medical Sciences
7 shared publications
In database
- Characterization of structurally novel G protein biased CB 1 agonists: Implications for drug development
- Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands
- Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors
- Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs
- Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein–Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with Δ9-Tetrahydrocannabinol and JWH-018
Showing 5 of 7 shared publications
Robert J. Shmookler Reis
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
- Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
Showing 5 of 7 shared publications
Konjeti R. Sekhar
Vanderbilt University Medical Center (US)
6 shared publications
- 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1)
- Targeting Nucleophosmin 1 Represents a Rational Strategy for Radiation Sensitization
- Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1
- Abstract 4905: Targeting NPM1 for the radiosensitization of NSCLC
- NPM1 as a Target for Radiosensitization of NSCLC Using a Genetic Model and Inhibitor YTR107
Showing 5 of 6 shared publications
Mónica L. Guzmán
Cornell University (US)
6 shared publications
- Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
- A novel tetrazole analogue of resveratrol is a potent anticancer agent
- Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents
- Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents
- The Acrylonitrile Analog, VJ-289 Ablates Acute Myelogenous Leukemia Blast, Progenitor and Stem Cell Populations by Inducing Tubulin Acetylation and Caspase Activation
Showing 5 of 6 shared publications
Jai Shankar K. Yadlapalli
University of Arkansas for Medical Sciences
6 shared publications
In database
- Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents
- A novel and efficient tributyltin azide-mediated synthesis of 1H-tetrazolylstilbenes from cyanostilbenes
- Evaluation of morphine‐like effects of the mixed mu/delta agonist morphine‐6‐O‐sulfate in rats: Drug discrimination and physical dependence
- (434) Analgesic profile of morphine 6-O-sulfate sodium: a mixed mu/delta agonist in the treatment of diabetic neuropathic pain
- Crystal structures of (Z)-5-[2-(benzo[b]thiophen-2-yl)-1-(3,5-dimethoxyphenyl)ethenyl]-1H-tetrazole and (Z)-5-[2-(benzo[b]thiophen-3-yl)-1-(3,4,5-trimethoxyphenyl)ethenyl]-1H-tetrazole
Showing 5 of 6 shared publications
Harikrishna Nakshatri
Richard L. Roudebush VA Medical Center (US)
6 shared publications
- Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer
- Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)
- Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model
- Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer
- Abstract P6-15-03: Dual targeting of mammary tumors and tumor-associated functional limitations through inhibition of NF-kB
Showing 5 of 6 shared publications
Srinivas Ayyadevara
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
- Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 6 shared publications
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