Match tier
Listed
Presence
Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
N
Narsimha Reddy Penthala
High Impact
Instructor
Also affiliated: University of Kentucky (2008–2011); American Association of Colleges of Pharmacy (2018); Richard L. Roudebush VA Medical Center (2017); Arkansas Department of Agriculture (2013); Indiana University School of Medicine (2017); University of Colorado Anschutz Medical Campus (2015); Indiana University – Purdue University Indianapolis (2017); University of Colorado Denver (2015)
Faculty Researcher
Pharmaceutics, College of Pharmacy
24 h-index
159 pubs
1,426 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Narsimha Reddy Penthala's research focuses on the pharmacological investigation of novel therapeutic agents, with a particular emphasis on cancer, neurodegenerative diseases, and drug delivery systems. His work includes the synthesis and evaluation of compounds designed to inhibit tumor growth and invasion, such as sesquiterpene lactone analogs that target NFκB signaling pathways. He has also explored the potential of thiadiazolidinone (TDZD) analogs to mitigate aggregation-related pathologies in models of neurodegeneration and to extend lifespan in *C. elegans*.
Further research areas include the development of anticholinesterase therapeutics for Alzheimer's disease and the assessment of drug toxicity and pharmacokinetics. Penthala has investigated the bone and kidney toxicity of potential antibiotic carriers and conducted pharmacokinetic studies of morphine-6-O-sulfate in rat models. His research employs diverse models, including patient-derived organoids and transgenic animal models, to assess the efficacy and safety of potential treatments. He leads a research group and has a publication record of 159 articles, with an h-index of 24 and over 1,400 citations.
Metrics
- h-index: 24
- Publications: 159
- Citations: 1,426
Selected Publications
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Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)
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Table S2 from Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer (2023)
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Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion (2021)
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Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease (2021)
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Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD) (2021)
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Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone (2021)
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A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain (2021)
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Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs (2020)
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Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands (2020)
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7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands (2020)
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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation (2020)
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Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model (2020)
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Oxone®-Mediated TEMPO-Oxidized Cellulose Nanomaterials form I and form II (2020)
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Aggregate Interactome Based on Protein-Crosslinking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases (2019)
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A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease (2019)
Grants & Funding
As listed on this researcher's institutional profile.
- Enhancing the prevention and treatment of orthopaedic infections associated with traumatic injury US Department of Defense Co-Investigator
- Development of Small Molecule Radiation Sensitizers NIH/Nat. Cancer Institute via Vanderbilt University Co-Investigator
- Development of Novel Therapeutics for Methamphetamine Abuse - Continuation NIH/Nat. Inst. on Drug Abuse via University of Kentucky Research Foundation Co-Investigator
- Early Events in Alzheimer Pathogenesis NIH Co-Investigator
- Novel melampomagnolide B-based prodrugs for the treatment of leukemia NIH Co-Investigator
Collaboration Network
Top Collaborators
Peter A. Crooks
University of Arkansas for Medical Sciences
7 shared publications
In database
- Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)
- Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone
Showing 5 of 7 shared publications
Meenakshisundaram Balasubramaniam
University of Arkansas for Medical Sciences
3 shared publications
In database
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
- Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)
Zaineb A.F. Albayati
University of Arkansas for Medical Sciences
2 shared publications
In database
- Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Poornima Bhat‐Nakshatri
Indiana University School of Medicine
2 shared publications
- Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)
- Table S2 from Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer
Harikrishna Nakshatri
Indiana University – Purdue University Indianapolis (US)
2 shared publications
- Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)
- Table S2 from Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer
Srinivas Ayyadevara
University of Arkansas for Medical Sciences
2 shared publications
In database
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Robert J. Shmookler Reis
Central Arkansas Veterans Healthcare System
2 shared publications
In database
- Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Jai Shankar K. Yadlapalli
University of Arkansas for Medical Sciences
1 shared publication
In database
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Philip J. Breen
University of Arkansas for Medical Sciences
1 shared publication
In database
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Maxim Dobretsov
University of Arkansas for Medical Sciences (US)
1 shared publication
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Howard P. Hendrickson
University of Arkansas for Medical Sciences (US)
1 shared publication
- A pharmacokinetic study of <scp>morphine‐6‐<i>O</i></scp>‐sulfate in rat plasma and brain
Shobanbabu Bommagani
University of Arkansas for Medical Sciences
1 shared publication
In database
- Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone
Ginell R. Post
University of Arkansas for Medical Sciences
1 shared publication
In database
- Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone
Mark S. Smeltzer
University of Arkansas for Medical Sciences
1 shared publication
In database
- Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone
Soma Shekar Dachavaram
University of Arkansas for Medical Sciences
1 shared publication
In database
- Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)
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