Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
N
Nathan C. Twaddle
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Senior Scientist / Toxicologist
Also affiliated: United States Food and Drug Administration (2004–2026); University of Illinois Urbana-Champaign (2005); Food and Drug Administration (2008)
Faculty Researcher
34 h-index
67 pubs
4,123 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nathan C. Twaddle's research investigates the toxicological effects of various compounds and environmental factors on biological systems, with a particular focus on neurodevelopmental and metabolic pathways. His work has explored the impact of inorganic arsenic on neuronal development in zebrafish, examining its influence on dopaminergic, serotonergic, and motor neurons through specific signaling pathways like Sonic hedgehog. Twaddle also studies the effects of dietary components, such as soy protein concentrates with varying isoflavone levels, on serum isoflavone profiles and inflammatory markers in rodent models of obesity and non-alcoholic fatty liver disease (NAFLD).
Further research by Twaddle includes analyzing elemental impurities in cannabis following vaporization and assessing the protective effects of compounds like Acetyl L-Carnitine against cardiotoxicity and developmental toxicity induced by environmental agents in zebrafish embryos. His scholarship metrics include an h-index of 34, with 67 total publications and over 4,107 citations, designating him as a highly cited researcher. He has collaborated with researchers Jyotshna Kanungo, Frederick A. Beland, and Camila Silva from the National Center for Toxicological Research, as well as Reza Hakkak from the University of Arkansas for Medical Sciences, with multiple shared publications.
Metrics
- h-index: 34
- Publications: 67
- Citations: 4,123
Selected Publications
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N-Acetylcysteine Prevents Arsenic-Induced Apoptosis but Not Supernumerary Motor Neuron Development in Zebrafish Embryos: Assessment of Protein Carbonylation and the p53 Pathway (2026)
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development (2025)
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Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024)
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Analysis of elemental impurities in cannabis following vaporization (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model (2022)
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Reduction by, ligand exchange among, and covalent binding to glutathione and cellular thiols link metabolism and disposition of dietary arsenic species with toxicity (2020)
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Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult and neonatal rhesus monkeys. VI. Toxicokinetic studies following oral administration (2019)
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A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results (2019)
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Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration (2019)
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Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency (2018)
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Metabolism and disposition of arsenic species from oral dosing with sodium arsenite in neonatal CD-1 mice. IV. Toxicokinetics following gavage administration and lactational transfer (2018)
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Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. III. Toxicokinetic studies following oral and intravenous administration (2018)
Collaboration Network
Top Collaborators
Reza Hakkak
Arkansas Children's Hospital
3 shared publications
In database
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Beverly J. Spray
Arkansas Children's Hospital (US)
3 shared publications
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Soheila Korourian
University of Arkansas for Medical Sciences
2 shared publications
In database
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Camila Silva
United States Food and Drug Administration
2 shared publications
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development
Frederick A. Beland
National Center for Toxicological Research
2 shared publications
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development
Jyotshna Kanungo
United States Food and Drug Administration
2 shared publications
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development
David M. Irby
1 shared publication
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Wei Li
University of Arkansas for Medical Sciences (US)
1 shared publication
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
Bernice Nounamo
University of Arkansas for Medical Sciences
1 shared publication
In database
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
Behjatolah Monzavi‐Karbassi
University of Arkansas for Medical Sciences
1 shared publication
In database
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
Tetyana Kudlyk
National Center for Toxicological Research
1 shared publication
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Volodymyr Tryndyak
United States Food and Drug Administration
1 shared publication
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Bonnie Robinson
National Center for Toxicological Research
1 shared publication
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Qiang Gu
National Center for Toxicological Research
1 shared publication
In database
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Suzanne Fitzpatrick
Center for Food Safety and Applied Nutrition (US)
1 shared publication
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
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