Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
N
Nathan C. Twaddle
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Senior Scientist / Toxicologist
Also affiliated: United States Food and Drug Administration (2004–2026); University of Illinois Urbana-Champaign (2005)
34 h-index
67 pubs
4,165 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nathan C. Twaddle's research investigates the toxicological effects of various compounds and environmental factors on biological systems, with a particular focus on neurodevelopmental and metabolic pathways. His work has explored the impact of inorganic arsenic on neuronal development in zebrafish, examining its influence on dopaminergic, serotonergic, and motor neurons through specific signaling pathways like Sonic hedgehog. Twaddle also studies the effects of dietary components, such as soy protein concentrates with varying isoflavone levels, on serum isoflavone profiles and inflammatory markers in rodent models of obesity and non-alcoholic fatty liver disease (NAFLD).
Further research by Twaddle includes analyzing elemental impurities in cannabis following vaporization and assessing the protective effects of compounds like Acetyl L-Carnitine against cardiotoxicity and developmental toxicity induced by environmental agents in zebrafish embryos. His scholarship metrics include an h-index of 34, with 67 total publications and over 4,107 citations, designating him as a highly cited researcher. He has collaborated with researchers Jyotshna Kanungo, Frederick A. Beland, and Camila Silva from the National Center for Toxicological Research, as well as Reza Hakkak from the University of Arkansas for Medical Sciences, with multiple shared publications.
Metrics
- h-index: 34
- Publications: 67
- Citations: 4,165
Positions
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Senior Scientist / ToxicologistProcter and Gamble ORCID
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Senior Scientist / Toxicologist publications 2002–2026National Center for Toxicological Research ORCID
Selected Publications
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N-Acetylcysteine Prevents Arsenic-Induced Apoptosis but Not Supernumerary Motor Neuron Development in Zebrafish Embryos: Assessment of Protein Carbonylation and the p53 Pathway (2026)
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development (2025)
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Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024)
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Analysis of elemental impurities in cannabis following vaporization (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model (2022)
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Reduction by, ligand exchange among, and covalent binding to glutathione and cellular thiols link metabolism and disposition of dietary arsenic species with toxicity (2020)
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Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult and neonatal rhesus monkeys. VI. Toxicokinetic studies following oral administration (2019)
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A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results (2019)
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Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration (2019)
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Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency (2018)
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Metabolism and disposition of arsenic species from oral dosing with sodium arsenite in neonatal CD-1 mice. IV. Toxicokinetics following gavage administration and lactational transfer (2018)
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Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. III. Toxicokinetic studies following oral and intravenous administration (2018)
Collaboration Network
Top Collaborators
Daniel R. Doerge
National Center for Toxicological Research
51 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Pharmacokinetics of bisphenol A in humans following a single oral administration
- Potential Neurotoxicity of Ketamine in the Developing Rat Brain
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula
Showing 5 of 51 shared publications
Mona I. Churchwell
National Center for Toxicological Research
24 shared publications
In database
- Pharmacokinetics of bisphenol A in humans following a single oral administration
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
- NIEHS/FDA CLARITY-BPA research program update
- 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
Showing 5 of 24 shared publications
Michelle M. Vanlandingham
National Center for Toxicological Research
17 shared publications
In database
- Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
- Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
- NIEHS/FDA CLARITY-BPA research program update
- Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
Showing 5 of 17 shared publications
Jeffrey W. Fisher
National Center for Toxicological Research (US)
13 shared publications
- Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
- Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
- Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
- Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
- 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
Showing 5 of 13 shared publications
Frederick A. Beland
National Center for Toxicological Research
12 shared publications
In database
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration
- Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells
- Metabolism and disposition of arsenic species after repeated oral dosing with sodium arsenite in drinking water. II. Measurements in pregnant and fetal CD-1 mice
Showing 5 of 12 shared publications
K. Barry Delclos
National Center for Toxicological Research
8 shared publications
In database
- NIEHS/FDA CLARITY-BPA research program update
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
- Lactational transfer of bisphenol A in Sprague–Dawley rats
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats
Showing 5 of 8 shared publications
Retha R. Newbold
National Institute of Environmental Health Sciences (US)
6 shared publications
- NIEHS/FDA CLARITY-BPA research program update
- Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats
- Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal mice
- Lactational transfer of the soy isoflavone, genistein, in Sprague–Dawley rats consuming dietary genistein
- Determination using liquid-chromatography–electrospray tandem mass spectroscopy of ethinylestradiol serum pharmacokinetics in adult Sprague–Dawley rats
Showing 5 of 6 shared publications
L. Patrice McDaniel
National Center for Toxicological Research (US)
5 shared publications
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide
- Autoclave Sterilization Produces Acrylamide in Rodent Diets: Implications for Toxicity Testing
William Slikker
United States Food and Drug Administration
5 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Potential Neurotoxicity of Ketamine in the Developing Rat Brain
- Pubertal delay in male nonhuman primates ( Macaca mulatta ) treated with methylphenidate
- Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Merle G. Paule
United States Food and Drug Administration
5 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Potential Neurotoxicity of Ketamine in the Developing Rat Brain
- Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates
- Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Justin Teeguarden
Oregon State University (US)
5 shared publications
- 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
- Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women
- 24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics
- Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency
- Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women I: Serum levels, variability and the basis for urinary biomonitoring of serum estrogenicity
Gonçalo Gamboa da Costa
National Center for Toxicological Research
4 shared publications
In database
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- NIEHS/FDA CLARITY-BPA research program update
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Luísa Camacho
National Center for Toxicological Research
3 shared publications
In database
- NIEHS/FDA CLARITY-BPA research program update
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Kellie A. Woodling
National Center for Toxicological Research
3 shared publications
In database
- Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Sherry A. Ferguson
National Center for Toxicological Research (US)
3 shared publications
- NIEHS/FDA CLARITY-BPA research program update
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
- Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats
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