Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
Biography and Research Information
OverviewAI-generated summary
Hannah Shibo Xu's research focuses on evaluating the toxicity of various chemical compounds, including bisphenol analogues and nitrosamines, across different biological systems and model organisms. Her work investigates the potential impacts of these substances on reproductive health, the nervous system, and the immune system, with a particular interest in their relationship to the gut microbiome and metabolism. Xu also examines the genotoxicity of compounds using advanced cell culture models, such as 2D and 3D HepaRG cells, and employs next-generation sequencing for accurate assessment. Her research extends to exploring the applications of artificial intelligence in medical contexts, as demonstrated by her evaluation of large language models for uveitis information. She collaborates with researchers at the National Center for Toxicological Research, including Ji-Eun Seo and Robert H. Heflich, and has published nine papers with a total of 189 citations, holding an h-index of 5.
Metrics
- h-index: 5
- Publications: 9
- Citations: 192
Selected Publications
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Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of <i>N</i> ‐Nitrosamines (2026)
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities (2025)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Application of HepaRG cells for genotoxicity assessment: a review (2024)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
Collaboration Network
Top Collaborators
Xiaoqing Guo
National Center for Toxicological Research
7 shared publications
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Application of HepaRG cells for genotoxicity assessment: a review
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Showing 5 of 7 shared publications
Timothy J. McGovern
Center for Drug Evaluation and Research (US)
5 shared publications
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
- Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of <i>N</i> ‐Nitrosamines
Robert H. Heflich
United States Food and Drug Administration
5 shared publications
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
Ji‐Eun Seo
National Center for Toxicological Research
4 shared publications
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Application of HepaRG cells for genotoxicity assessment: a review
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Karen L Davis Bruno
United States Food and Drug Administration (US)
4 shared publications
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Nan Mei
National Center for Toxicological Research
4 shared publications
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Aisar Atrakchi
United States Food and Drug Administration (US)
3 shared publications
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Javier R. Revollo
National Center for Toxicological Research
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Jaime A. Miranda
National Center for Toxicological Research
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Tong Zhou
United States Food and Drug Administration (US)
2 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Jessica A. Bonzo
Center for Drug Evaluation and Research (US)
2 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Xilin Li
National Center for Toxicological Research
2 shared publications
In database
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
J.H. Seo
National Center for Toxicological Research
2 shared publications
In database
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Naomi L. Kruhlak
Center for Drug Evaluation and Research (US)
2 shared publications
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
- Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of <i>N</i> ‐Nitrosamines
Joshua Z. Yu
National Center for Toxicological Research
1 shared publication
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
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