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Presence
Current · Arkansas
Last published
2026
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OpenAlex · ORCID
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2026-10-07
J
Ji‐Eun Seo
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
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Also affiliated: United States Food and Drug Administration (2018–2025); Yonsei University (2025); Yonsei University Health System (2025); Korea Research Institute of Bioscience and Biotechnology (2011–2025)
15 h-index
27 pubs
494 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Ji-Eun Seo's research focuses on evaluating the mutagenicity and genotoxicity of chemical compounds, particularly nitrosamines, using in vitro cell models. She has investigated the application of HepaRG cells, including those cultured in three-dimensional spheroids, for genotoxicity testing. Her work has employed various assays, such as the Comet assay and micronucleus tests, to assess DNA damage and mutations. Seo has also explored the use of error-corrected next-generation sequencing for evaluating mutagenicity and has reviewed the application of HepaRG cells for genotoxicity assessment. Her research collaborators include Xiaoqing Guo, Nan Mei, Robert H. Heflich, and Yuan Le, all from the National Center for Toxicological Research, with whom she has co-authored multiple publications.
Metrics
- h-index: 15
- Publications: 27
- Citations: 494
Selected Publications
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DNA Damage and Micronucleus Induction by Small‐Molecule Nitrosamine Drug Impurities and Nitrosamine Drug Substance‐Related Impurities in HepaRG Cells (2026)
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models (2026)
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Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025)
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Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error‐Corrected Sequencing (2025)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities (2025)
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Isolation and Cryopreservation of Primary Macaque Hepatocytes (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Application of HepaRG cells for genotoxicity assessment: a review (2024)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
Collaboration Network
Top Collaborators
Xiaoqing Guo
National Center for Toxicological Research
23 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
Showing 5 of 23 shared publications
Nan Mei
United States Food and Drug Administration
15 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
Showing 5 of 15 shared publications
Robert H. Heflich
National Center for Toxicological Research
9 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Showing 5 of 9 shared publications
Timothy J. McGovern
United States Food and Drug Administration (US)
7 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Showing 5 of 7 shared publications
Xilin Li
National Center for Toxicological Research
6 shared publications
In database
- Genetic toxicity assessment using liver cell models: past, present, and future
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 6 shared publications
Aisar Atrakchi
Center for Drug Evaluation and Research (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Showing 5 of 6 shared publications
Karen L Davis Bruno
United States Food and Drug Administration (US)
6 shared publications
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models
Showing 5 of 6 shared publications
Matthew Bryant
National Center for Toxicological Research
5 shared publications
In database
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Hannah Xu
United States Food and Drug Administration
5 shared publications
In database
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Application of HepaRG cells for genotoxicity assessment: a review
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Javier R. Revollo
National Center for Toxicological Research
5 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error‐Corrected Sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
- Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Jaime A. Miranda
National Center for Toxicological Research
5 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error‐Corrected Sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
- Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Tong Zhou
Center for Veterinary Medicine (US)
4 shared publications
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Timothy W. Robison
United States Food and Drug Administration (US)
4 shared publications
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
Yuan Le
National Center for Toxicological Research
4 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Review of black cohosh-induced toxicity and adverse clinical effects
David A. Keire
United States Food and Drug Administration (US)
4 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models
- Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
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