Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-16
Biography and Research Information
OverviewAI-generated summary
James D. Sikes investigates the interplay between diet, the gut microbiome, and host physiology, with a particular focus on metabolic health and host-microbe interactions. His research utilizes animal models, including mice and piglets, to explore how dietary interventions, such as high-fat diets, and environmental factors, like housing temperature, influence energy expenditure, adipocyte function, and gut microbiota composition. Sikes also examines the impact of maternal diet on offspring development and metabolic health, as well as the role of specific microbial communities in host physiology. His work has been supported by collaborations with researchers at the University of Arkansas for Medical Sciences, including Umesh D. Wankhade, Henry A. Paz, Craig Porter, and D Sadler.
His publication record includes studies on energy expenditure in mice, regenerative responses in holobionts, and the effects of maternal high-fat diets on offspring gut microbiota. Sikes has also published on the influence of parental cardiorespiratory fitness on early life energetics and metabolic health, and the regeneration mechanisms in acoel species. His research metrics include an h-index of 12, with 49 total publications and 799 total citations.
Metrics
- h-index: 12
- Publications: 49
- Citations: 799
Selected Publications
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The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue (2025)
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Western Diet Modifies Platelet Activation Profiles in Male Mice (2024)
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Parental cardiorespiratory fitness influences early life energetics and metabolic health (2023)
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A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice (2022)
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Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge (2022)
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Genital Chlamydia infection in hyperlipidemic mouse models exacerbates atherosclerosis (2019)
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Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices (2018)
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IL-33 and IL-13 Receptors Are Upregulated in Precision Cut Lung Slices from Donors with Asthma during RV39 Infection (2017)
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Long-term Walnut Oral Immunotherapy Induces Clinically Relevant Treatment Responses in Tree Nut Allergic Children (2017)
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IL-12 secretion by Langerhans cells stimulated with Candida skin test reagent is mediated by dectin-1 in some healthy individuals (2013)
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Significant Role of IL-1 Signaling, but Limited Role of Inflammasome Activation, in Oviduct Pathology during <i>Chlamydia muridarum</i> Genital Infection (2012)
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Significant role of IL-1 signaling, but limited role of inflammasome activation in oviduct pathology during <i>Chlamydia muridarum</i> genital infection (110.6) (2011)
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Interferon Regulatory Transcription Factor 3 Protects Mice from Uterine Horn Pathology during Chlamydia muridarum Genital Infection (2011)
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MyD88 Deficiency Leads to Decreased NK Cell Gamma Interferon Production and T Cell Recruitment during<i>Chlamydia muridarum</i>Genital Tract Infection, but a Predominant Th1 Response and Enhanced Monocytic Inflammation Are Associated with Infection Resolution (2010)
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NK cells inability to produce IFN gamma in MyD88-/- mice contributes to the delayed clearance of Chlamydia muridarum primary genital infection (133.2) (2009)
Collaboration Network
Top Collaborators
Henry A. Paz
University of Arkansas for Medical Sciences
2 shared publications
In database
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue
Ying Zhong
University of Arkansas for Medical Sciences
2 shared publications
In database
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue
Umesh D. Wankhade
University of Arkansas for Medical Sciences
2 shared publications
In database
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
- The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue
D Sadler
Arkansas Children's Nutrition Center
2 shared publications
In database
- A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Lillie Treas
Arkansas Children's Nutrition Center
2 shared publications
In database
- A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Craig Porter
Arkansas Children's Hospital
2 shared publications
In database
- A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Anna‐Claire Pilkington
University of Arkansas for Medical Sciences
1 shared publication
In database
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Sree V. Chintapalli
Arkansas Children's Nutrition Center
1 shared publication
In database
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Renny S. Lan
University of Arkansas for Medical Sciences
1 shared publication
In database
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Kartik Shankar
University of Colorado Anschutz Medical Campus (US)
1 shared publication
- Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Taylor Ross
Arkansas Children's Hospital (US)
1 shared publication
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Steven L. Britton
Michigan United (US)
1 shared publication
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Lauren G. Koch
University of Toledo (US)
1 shared publication
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Brian D. Piccolo
Arkansas Children's Hospital
1 shared publication
In database
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Elisabet Børsheim
University of Arkansas for Medical Sciences
1 shared publication
In database
- Parental cardiorespiratory fitness influences early life energetics and metabolic health
Similar Researchers
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