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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
A
Akshatha Ganne
Post Doctoral Fellow
Also affiliated: Central Arkansas Veterans Healthcare System (2022); Institute on Aging (2017–2024)
Postdoc Researcher
11 h-index
21 pubs
293 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Akshatha Ganne's research focuses on understanding the molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS). Her work investigates the role of protein aggregates, intrinsically disordered proteins, and their interactions with nucleic acids in disease progression. Ganne has explored glial fibrillary acidic protein as a potential biomarker and therapeutic target for Alzheimer's disease. She has also examined the impact of protein aggregation on cellular stress, including myocardial infarction's effects on both heart and brain tissue. Her research utilizes computational analysis, such as machine learning, to identify factors contributing to neurodegeneration-related aggregation and in silico analysis to define disease mechanisms, as seen in her work on TUBA4A mutations in ALS. Ganne collaborates with researchers at the University of Arkansas for Medical Sciences, including Meenakshisundaram Balasubramaniam, Robert J. Shmookler Reis, and Srinivas Ayyadevara.
Metrics
- h-index: 11
- Publications: 21
- Citations: 293
Selected Publications
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Zolpidem restores sleep and decreases amyloid in a mouse model (2026)
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The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026)
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Zolpidem restores sleep and slows Alzheimer’s progression in a mouse model (2025)
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Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024)
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Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
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Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023)
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Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023)
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Protein homeostasis in the aged and diseased heart (2023)
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In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration (2023)
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Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases (2022)
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Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation (2022)
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Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease (2022)
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In Silico Analysis of TUBA4A Mutations in Amyotrophic Lateral Sclerosis to Define Mechanisms of Microtubule Disintegration (2022)
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Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease (2021)
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Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration (2021)
Collaboration Network
Top Collaborators
Meenakshisundaram Balasubramaniam
University of Arkansas for Medical Sciences
14 shared publications
In database
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
Showing 5 of 14 shared publications
Robert J. Shmookler Reis
Geriatric Research Education and Clinical Center
12 shared publications
In database
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
Showing 5 of 12 shared publications
Srinivas Ayyadevara
University of Arkansas at Little Rock
12 shared publications
In database
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
- Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation
Showing 5 of 12 shared publications
Nirjal Mainali
Institute on Aging
5 shared publications
In database
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets
- Protein homeostasis in the aged and diseased heart
Ramani Atluri
Institute on Aging
3 shared publications
In database
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
Haarika Ayyadevara
University of Arkansas at Fayetteville
3 shared publications
In database
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In Silico Analysis of TUBA4A Mutations in Amyotrophic Lateral Sclerosis to Define Mechanisms of Microtubule Disintegration
Sonu Pahal
University of Arkansas at Little Rock
3 shared publications
In database
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease
W. Sue T. Griffin
Central Arkansas Veterans Healthcare System
2 shared publications
In database
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease
Lily Kiaei
University of California, Los Angeles (US)
2 shared publications
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In Silico Analysis of TUBA4A Mutations in Amyotrophic Lateral Sclerosis to Define Mechanisms of Microtubule Disintegration
Kottayil I. Varughese
University of Arkansas for Medical Sciences (US)
2 shared publications
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In Silico Analysis of TUBA4A Mutations in Amyotrophic Lateral Sclerosis to Define Mechanisms of Microtubule Disintegration
Mahmoud Kiaei
Arkansas Department of Agriculture
2 shared publications
In database
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration
- In Silico Analysis of TUBA4A Mutations in Amyotrophic Lateral Sclerosis to Define Mechanisms of Microtubule Disintegration
Jawahar L. Mehta
Central Arkansas Veterans Healthcare System
2 shared publications
In database
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain
- Protein homeostasis in the aged and diseased heart
Jay E. Johnson
University of Arkansas for Medical Sciences (US)
1 shared publication
- “Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation
Robert Joseph Shmookler Reis
Central Arkansas Veterans Healthcare System (US)
1 shared publication
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease
W. Sue T. Griffin
University of Arkansas for Medical Sciences
1 shared publication
In database
- Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease
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