Oxana P. Lazarenko
Researcher
University of Arkansas for Medical Sciences
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Biography and Research Information
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Oxana P. Lazarenko's research investigates the molecular mechanisms underlying bone development and maintenance, with a focus on the role of specific genes and cellular processes in bone health and disease. Her work has explored the function of G-protein coupled receptor 109A (GPR109A) in regulating osteoclastogenesis and bone resorption, as well as the impact of Nox4 expression in osteo-progenitors on skeletal development. Lazarenko has also examined the influence of epigenetic modifications, such as H3K27me3 and H3K27ac, in bone cells in response to maternal diet during early life, and how these modifications affect offspring osteoblastogenesis.
Her research extends to the effects of various factors on bone loss, including sex-steroid deficiency and high-fat diets. Publications detail how phenolic acids can prevent bone loss induced by sex-steroid deficiency and how short-term increases in physical activity during early life can affect high-fat diet-induced bone loss in young adult mice. Lazarenko has also investigated the role of Ezh2 in myeloid cells in regulating bone resorption. Her work includes collaborations with Jin‐Ran Chen, Michael L. Blackburn, Perry C. Caviness, and Umesh D. Wankhade at the University of Arkansas for Medical Sciences, with whom she has co-authored multiple publications.
Lazarenko's scholarship metrics include an h-index of 24, 66 total publications, and 1,956 total citations. She is recognized as a highly cited researcher. Her research also encompasses observational studies on skeletal development in children across different formula feeding groups.
Metrics
- h-index: 24
- Publications: 66
- Citations: 1,956
Selected Publications
- A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence (2026) DOI
- Soy Isoflavones Prevent Bone Quality Loss Induced by High‐Fat Diet in Rats Through Epigenetic Modifications (2025) DOI
- Sex dependent effects of GPR109A gene deletion in myeloid cells on bone development in mice (2025) DOI
- Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption (2025) DOI
- Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx (2024) DOI
- Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice (2024) DOI
- Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model (2023) DOI
- A longitudinal observational study of skeletal development between ages 3 mo and 6 y in children fed human milk, milk formula, or soy formula (2023) DOI
- Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice (2022) DOI
- Nox4 expression in osteo-progenitors controls bone development in mice during early life (2022) DOI
- GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice (2022) DOI
- <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice (2021) DOI
- Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in mice (2021) DOI
- GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice (2021) DOI
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