Lemuel A. Brown
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Researcher
Also affiliated: Eastern Washington University (2012); University of Michigan (2017–2021); Michigan United (2017–2018); Michigan Medicine (2018–2019); Stavros (2015); Laboratoire d’immunologie intégrative du cancer (2020); Crouse Hospital (2015); Southern Illinois University Edwardsville (2016); Texas A&M University (2015)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Lemuel A. Brown investigates skeletal muscle aging, regeneration, and the impact of metabolic conditions such as obesity and cancer cachexia on muscle tissue. His research utilizes rodent models to study the cellular and molecular mechanisms underlying muscle dysfunction. Recent work has focused on the role of muscle stem cells and their response to aging and neuromuscular junction perturbations. Brown has also explored the influence of diet-induced obesity and PGC-1α overexpression on skeletal muscle regeneration and fibrosis development.
His scholarship has examined age-related deficiencies in pro-resolving mediators within skeletal muscle, contributing to maladaptive tissue remodeling. Furthermore, Brown's research has investigated sex differences in fibrosis development during cancer cachexia. With an h-index of 23 and over 1,500 citations across 82 publications, his work is recognized as highly cited. He has a history of collaboration with researchers at the University of Arkansas at Fayetteville, including Megan E. Rosa-Caldwell, Tyrone A. Washington, Eleanor R. Schrems, and Wesley S. Haynie, with whom he shares four co-authored publications.
Metrics
- h-index: 23
- Publications: 82
- Citations: 1,592
Selected Publications
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Development of skeletal muscle fibrosis in a rodent model of cancer cachexia (2023)
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Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia (2023)
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Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration (2022)
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The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration (2021)
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Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice (2020)
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Cancer‐induced cardiac atrophy adversely affects myocardial redox state and mitochondrial oxidative characteristics (2020)
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Graft alignment impacts the regenerative response of skeletal muscle after volumetric muscle loss in a rat model (2020)
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Graft Alignment Impacts the Regenerative Response of Skeletal Muscle after Volumetric Muscle Loss in a Rat Model (2019)
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Regulation of mitochondrial quality following repeated bouts of hindlimb unloading (2019)
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Preliminary study: Leucine Supplementation Exacerbates Muscle Wasting Independent of the Ubiquitin-Proteasome System (2019)
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The Development of Cancer Cachexia Negatively Impacts Skeletal Muscle Extracellular Matrix Remodeling (2019)
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Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice (2019)
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Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice (2018)
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Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice (2018)
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Cardiac hypertrophy in sarcopenic obese C57BL/6J mice is independent of Akt/mTOR cellular signaling (2018)
Collaboration Network
Top Collaborators
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- The effect of diet-induced obesity on extracellular matrix remodeling during skeletal muscle regeneration
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
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