S
Seongkyun Lim Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Assistant
grad_student
12 h-index
42 pubs
450 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Seongkyun Lim's research focuses on the molecular and physiological adaptations of skeletal muscle, with a particular emphasis on sex-specific differences and the impact of various stimuli, including disuse, aging, and cancer cachexia. Lim's work has investigated the global and MYC regulatory networks involved in skeletal muscle growth following acute stimuli, utilizing multi-transcriptome analysis. Studies have explored the development of metabolic and contractile alterations in cancer cachexia in female tumor-bearing mice, revealing biphasic transcriptional disruptions distinct from males. Furthermore, Lim's research has examined mitochondrial aberrations during disuse atrophy, noting differential effects in male and female mice, and has identified how muscle miR-16 deletion can impair insulin sensitivity and contractile function in a sex-dependent manner.
This research contributes to understanding the complex interplay of genetic and environmental factors influencing muscle health and function across the lifespan and in disease states. Lim's work has been supported by federal grants from the NSF, including awards totaling $775,000 for projects focused on dynamic modeling of river ecosystem stability. Collaborations with researchers at the University of Arkansas at Fayetteville, such as Francielly Morena da Silva, Tyrone A. Washington, Nicholas P. Greene, and Eleanor R. Schrems, have resulted in numerous shared publications, underscoring a productive research network.
Metrics
- h-index: 12
- Publications: 42
- Citations: 450
Selected Publications
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Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females (2025)
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Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice (2025)
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Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice (2024)
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Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia (2023)
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The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males (2023)
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Development of skeletal muscle fibrosis in a rodent model of cancer cachexia (2023)
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MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16 (2023)
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Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia (2023)
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A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle (2022)
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The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males (2022)
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Differential Induction Of Regulators Of Protein Turnover During C26-induced Cancer Cachexia Between Biological Sexes (2022)
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Males, But Not Females, Demonstrate Mitochondrial Dysfunction In The C26 Model Of Cancer Cachexia (2022)
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PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice (2022)
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Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner (2022)
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Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice (2021)
Federal Grants 2 $775,000 total
NSF
Co-PI
Oct 2025 - Sep 2026
SCC-CIVIC-FA Track A: Dynamic Modeling of River Ecosystem Stability
NSF
Co-PI
Oct 2024 - Jun 2025
Collaboration Network
Top Collaborators
Nicholas P. Greene
24 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
Showing 5 of 24 shared publications
Francielly Morena da Silva
University of Arkansas at Fayetteville
20 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
Showing 5 of 20 shared publications
Tyrone A. Washington
University of Arkansas at Fayetteville
20 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 20 shared publications
Eleanor R. Schrems
University of Arkansas at Fayetteville
15 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Showing 5 of 15 shared publications
Ana Regina Cabrera
University of Arkansas at Fayetteville
14 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
Showing 5 of 14 shared publications
Kevin A. Murach
University of Arkansas at Fayetteville
11 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16
Showing 5 of 11 shared publications
Megan E. Rosa‐Caldwell
Harvard University
10 shared publications
In database
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Showing 5 of 10 shared publications
Landen W. Saling
University of Arkansas at Fayetteville
10 shared publications
In database
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- Growth Differentiation Factor 5 Is A Paracrine Regulator In Sarcopenic Obesity
Showing 5 of 10 shared publications
J. William Deaver
University of Arkansas at Fayetteville (US)
8 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Males, But Not Females, Demonstrate Mitochondrial Dysfunction In The C26 Model Of Cancer Cachexia
Showing 5 of 8 shared publications
Sabin Khadgi
University of Arkansas at Fayetteville
7 shared publications
In database
- Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females
- A Rejuvenation Signature in Skeletal Muscle That Is Mediated By Late-Life Exercise
Showing 5 of 7 shared publications
Jacob L. Brown
University of Arkansas at Fayetteville (US)
5 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
- Biological Sex Differences of Fibrosis During the Development of Cancer Cachexia
David E. Lee
University of Arkansas at Fayetteville (US)
5 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner
- Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
- MicroRNA control of the myogenic cell transcriptome and proteome: the role of miR-16
Michael P. Wiggs
Baylor University (US)
5 shared publications
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
- Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Males, But Not Females, Demonstrate Mitochondrial Dysfunction In The C26 Model Of Cancer Cachexia
Ronald G. Jones
University of Arkansas at Fayetteville
5 shared publications
In database
- A molecular signature defining exercise adaptation with ageing and <i>in vivo</i> partial reprogramming in skeletal muscle
- The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
- The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
- A Rejuvenation Signature in Skeletal Muscle That Is Mediated By Late-Life Exercise
- Mitochondria-Targeted Antioxidant SkQ1 Improves Muscle Contractility in Female C26 Tumor-Bearing Mice
Stavroula Tsitkanou
University of Arkansas at Fayetteville
5 shared publications
In database
- Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
- Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice
- Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females
- Mitochondria-Targeted Antioxidant SkQ1 Improves Muscle Contractility in Female C26 Tumor-Bearing Mice
- Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice
Similar Researchers
Based on overlapping research topics
Eleanor Schrems
University of Arkansas at Fayetteville
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Wesley S. Haynie
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Sabin Khadgi
University of Arkansas at Fayetteville
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Calvin Peterson
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KiranKumar Adepu
University of Arkansas for Medical Sciences
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Nicholas P. Greene
University of Arkansas at Fayetteville
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