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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
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2026-10-05
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Barbara L. Parsons
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Microbiogist
Also affiliated: Agricultural Research Service (1991–1992); United States Food and Drug Administration (2002–2026); United States Department of Agriculture (1991–1992); Institute of Cancer Research (2011); Brookhaven National Laboratory (1982); Cold Spring Harbor Laboratory (1982–1983); Fred Hutch Cancer Center (1982); Central Arkansas Veterans Healthcare System (2007); Beltsville Agricultural Research Center (1991–1992); Duke Medical Center (1984–1990); Stony Brook University (1982); University of California, Berkeley (1982)
28 h-index
90 pubs
2,540 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Barbara L. Parsons, a Research Microbiologist at the National Center for Toxicological Research, focuses her work on genotoxicity and carcinogenicity assessment, particularly employing advanced sequencing technologies. Her research investigates the detection and interpretation of genetic mutations in the context of cancer risk. Parsons has published on the use of error-corrected next-generation sequencing (NGS) to improve the accuracy of genotoxicity testing and cancer risk assessment, highlighting its promises and challenges.
Her work includes the development and application of genomic reference samples for assessing the performance of cancer panels in detecting small genetic variants. Parsons has also explored the measurement of cancer driver mutations using CarcSeq technology in various tissues and their correlation with spontaneous neoplasia in animal models, such as rats and mice. She collaborates with several researchers at the National Center for Toxicological Research, including Meagan B. Myers, Robert H. Heflich, Binsheng Gong, and Kelly L. Harris, with whom she has co-authored multiple publications. Parsons has an h-index of 29 and has published a total of 144 papers, accumulating over 2,756 citations.
Metrics
- h-index: 28
- Publications: 90
- Citations: 2,540
Positions
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Research Microbiogist 2002–presentNational Center for Toxicological Research Genetic and Molecular Toxicology ORCID
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Staff Fellow 1998–2002National Center for Toxicological Research Genetic and Molecular Toxicology ORCID
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Research Microbiologist 1995–1998Department of Veterans Affairs USFDA/National Center for Toxicological Research ORCID
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NCTR Postdoctoral Fellow 1994–1995Oak Ridge Institute for Science and Education US FDA/National Center for Toxicological Research ORCID
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Staff Research Associate 1992–1994University of Arkansas at Little Rock Biology ORCID
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Postdoctoral Research Assoicate 1988–1992USDA-ARS Beltsville Agricultural Research Center Plant Molecular Biology ORCID
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Graduate Research Assistant 1982–1988Duke University Microbiology and Immunology ORCID
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Research Technician 1980–1982Cold Spring Harbor Laboratory Richard Roberts Laboratory ORCID
Selected Publications
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Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung (2026)
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Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in rasH2 ‐Tg Mice (2025)
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Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing (2025)
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Clonal expansion of cancer driver gene mutants investigated using advanced sequencing technologies (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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CarcSeq detection of lorcaserin-induced clonal expansion ofPik3caH1047R mutants in rat mammary tissue (2024)
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Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing ( IWGT ) (2024)
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Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq (2024)
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Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting (2023)
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Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment (2023)
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Interpretation of In Vitro Concentration-Response Data for Risk Assessment and Regulatory Decision-making: Report from 2022 IWGT Quantitative Analysis Expert Working Group Meeting (2023)
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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing (2023)
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Launching the “Projections” series in mutation research reviews with a special issue on next generation sequencing (2021)
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Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia (2021)
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A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency (2021)
Collaboration Network
Top Collaborators
Meagan B. Myers
National Center for Toxicological Research
32 shared publications
In database
- Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas
- Personalized cancer treatment and the myth of KRAS wild-type colon tumors.
Showing 5 of 32 shared publications
Karen L. McKim
National Center for Toxicological Research
23 shared publications
In database
- Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas
- Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide
- A subset of papillary thyroid carcinomas contain KRAS mutant subpopulations at levels above normal thyroid
- ACB‐PCR measurement of H‐ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues
- Variation in organ‐specific PIK3CA and KRAS mutant levels in normal human tissues correlates with mutation prevalence in corresponding carcinomas
Showing 5 of 23 shared publications
Robert H. Heflich
National Center for Toxicological Research
18 shared publications
In database
- Genotypic selection methods for the direct analysis of point mutations
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Evaluation of MutS as a tool for direct measurement of point mutations in genomic DNA
- Detection of basepair substitution mutation at a frequency of 1 × 10−7 by combining two genotypic selection methods, MutEx enrichment and allele-specific competitive blocker PCR
Showing 5 of 18 shared publications
Page B. McKinzie
National Center for Toxicological Research
13 shared publications
In database
- Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
- Oncomutations as biomarkers of cancer risk
Showing 5 of 13 shared publications
Malathi Banda
National Center for Toxicological Research
10 shared publications
In database
- Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas
- Outgrowth of erlotinib-resistant subpopulations recapitulated in patient-derived lung tumor spheroids and organoids
- Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status
- Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation
- ACB‐PCR measurement of spontaneous and furan‐induced H‐ras Codon 61 CAA to CTA and CAA to AAA mutation in B6C3F1 mouse liver
Showing 5 of 10 shared publications
Fanxue Meng
National Center for Toxicological Research (US)
9 shared publications
- K‐Ras mutant fraction in A/J mouse lung increases as a function of benzo[a]pyrene dose
- K- RAS Mutation in the Screening, Prognosis and Treatment of Cancer
- Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde
- Oncomutations as biomarkers of cancer risk
- Low-Frequency Kras Mutations are Prevalent in Lung Adenocarcinomas
Showing 5 of 9 shared publications
Robert R. Delongchamp
University of Arkansas for Medical Sciences
8 shared publications
In database
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- Levels of 4‐aminobiphenyl‐induced somatic H‐ras mutation in mouse liver DNA correlate with potential for liver tumor development
- ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue(R) rats treated with N-hydroxy-2-acetylaminofluorene
- Simulated solar light‐induced p53 mutagenesis in SKH‐1 mouse skin: A dose–response assessment
Showing 5 of 8 shared publications
Yiying Wang
National Center for Toxicological Research (US)
7 shared publications
- Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide
- ACB‐PCR measurement of H‐ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues
- p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene
- Hotspot oncomutations: implications for personalized cancer treatment
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Showing 5 of 7 shared publications
Binsheng Gong
National Center for Toxicological Research
7 shared publications
In database
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- Quantification of cancer driver mutations in human breast and lung DNA using targeted, error‐corrected CarcSeq
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in rasH2 ‐Tg Mice
Showing 5 of 7 shared publications
Tracie L. Verkler
National Center for Toxicological Research (US)
6 shared publications
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- ACB-PCR Quantification of K-RASCodon 12 GAT and GTT Mutant Fraction in Colon Tumor and Non-Tumor Tissue
- Simulated solar light‐induced p53 mutagenesis in SKH‐1 mouse skin: A dose–response assessment
- Populations of p53 codon 270 CGT to TGT mutant cells in SKH‐1 mouse skin tumors induced by simulated solar light
- Quantifying levels ofp53 mutation in mouse skin tumors
Showing 5 of 6 shared publications
B. Bhaskar Gollapudi
Exponent (United States) (US)
6 shared publications
- Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide
- Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation
- Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations
- Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting
- Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing ( IWGT )
Showing 5 of 6 shared publications
Kelly L. Harris
National Center for Toxicological Research
6 shared publications
In database
- Quantification of cancer driver mutations in human breast and lung DNA using targeted, error‐corrected CarcSeq
- Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in rasH2 ‐Tg Mice
Showing 5 of 6 shared publications
Jennifer Faske
National Center for Toxicological Research
5 shared publications
In database
- CarcSeq detection of lorcaserin-induced clonal expansion ofPik3caH1047R mutants in rat mammary tissue
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in rasH2 ‐Tg Mice
- Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq
- Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung
Tao Chen
National Center for Toxicological Research (US)
4 shared publications
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- 4‐Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice
- ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue(R) rats treated with N-hydroxy-2-acetylaminofluorene
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Mugimane G. Manjanatha
National Center for Toxicological Research
4 shared publications
In database
- Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide
- Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression
- Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations
- The 40th anniversary of the Environmental Mutagen Society
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