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Biography and Research Information
OverviewAI-generated summary
Ashley Herdman's research investigates the impact of diet and aging on the pituitary gland, particularly focusing on the role of leptin receptor signaling in somatotropes. Herdman's work has explored how high-fat diets influence anterior pituitary transcriptomics, with an emphasis on oxidative stress and cell metabolism. Further studies examine the consequences of ablating leptin receptor signaling in female mice, revealing alterations in somatotrope transcriptome maturation and pituitary plasticity in aging animals. Herdman has also investigated gonadotrope remodeling in states of sustained low estrogen and the influence of secretoneurin on luteinizing hormone secretion. Collaborations include extensive work with Angela K. Odle, Melanie C MacNicol, Angus M. MacNicol, and Alex Lagasse at the University of Arkansas for Medical Sciences, with whom Herdman shares nine publications.
Metrics
- h-index: 2
- Publications: 10
- Citations: 20
Positions
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PhD Candidate 2020–presentUniversity of Arkansas for Medical Sciences Department of Neuroscience ORCID
Selected Publications
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023)
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FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023)
Collaboration Network
Top Collaborators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 8 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 8 shared publications
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries
- OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion
- Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
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