Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Angela Katherine Odle
Federal Grant PI
Assistant Professor
Also affiliated: Consejo Superior de Investigaciones Científicas (2023); Instituto de Neurociencias (2023)
Neurobiology & Developmental Science, College of Medicine
17 h-index
73 pubs
1,228 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Angela Katherine Odle investigates the role of leptin in regulating metabolic and reproductive functions, with a particular focus on its impact on the pituitary gland. Her research explores how leptin signaling influences somatotrophs, the cells responsible for producing growth hormone, and gonadotropes, which are critical for reproductive processes. Odle's work has demonstrated that leptin receptors are present on somatotropes and that their deletion leads to obesity, suggesting a role for these cells as metabolic sensors. Furthermore, she has examined how leptin regulates gonadotropin-releasing hormone receptors in gonadotropes, identifying this pathway as a key metabolic checkpoint for reproductive competence.
Her research extends to understanding how disruptions in leptin signaling can affect fertility and how partial leptin reduction may serve as a strategy for improving insulin sensitivity and promoting weight loss. Odle has also investigated the involvement of adipo-glial signaling in peripheral nerve regeneration and metabolic adaptation. Her work is supported by federal funding, including a grant from the NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development for studying paracrine and endocrine influences on gonadotrope development and function. Odle leads a research group and has a significant publication record, with over 70 publications and a h-index of 17. She frequently collaborates with researchers at the University of Arkansas for Medical Sciences, including Gwen V. Childs, Angus M. MacNicol, Melanie C MacNicol, and Alex Lagasse.
Metrics
- h-index: 17
- Publications: 73
- Citations: 1,228
Positions
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Assistant Professor 2019–presentUniversity of Arkansas for Medical Sciences Neurobiology & Developmental Science, College of Medicine Institutional directory
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Instructor 2018–2019University of Arkansas for Medical Sciences Neurobiology and Developmental Sciences ORCID
Selected Publications
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation (2026)
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ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation (2026)
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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Solving the Mystery of the Neonatal GH Surge (2024)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024)
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Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024)
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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023)
Federal Grants 1 $443,348 total
NIH
Contact PI
Jul 2026 - Apr 2031
Paracrine and Endocrine Influences on Gonadotrope Development and Function
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Enhancement Project to Improve Access to Food Services and Mental Well-Being Administration for Community Living Principal Investigator
- The Impact of Obesity on Somatotrope Function NIH Co-Investigator
- Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes NIH Co-Investigator
- The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes NIH Co-Investigator
- Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Co-Investigator
Collaboration Network
Top Collaborators
Gwen V. Childs
University of Arkansas for Medical Sciences
56 shared publications
In database
- Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity
- Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility
Showing 5 of 56 shared publications
Angus M. MacNicol
University of Arkansas for Medical Sciences
42 shared publications
In database
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
Showing 5 of 42 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
38 shared publications
In database
- The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity
- Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility
- Adipocyte Versus Pituitary Leptin in the Regulation of Pituitary Hormones: Somatotropes Develop Normally in the Absence of Circulating Leptin
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males
Showing 5 of 38 shared publications
Melanie C MacNicol
University of Arkansas for Medical Sciences
37 shared publications
In database
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- The use of three-dimensional printing to produce in vitro slice chambers
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
Showing 5 of 37 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
23 shared publications
In database
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Sex differences in somatotrope response to fasting: biphasic responses in male mice
Showing 5 of 23 shared publications
Melody Allensworth‐James
University of Arkansas for Medical Sciences
20 shared publications
In database
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility
- Adipocyte Versus Pituitary Leptin in the Regulation of Pituitary Hormones: Somatotropes Develop Normally in the Absence of Circulating Leptin
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males
Showing 5 of 20 shared publications
Alex Lagasse
University of Arkansas for Medical Sciences
18 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 18 shared publications
Ana Rita Silva Moreira
University of Arkansas for Medical Sciences (US)
16 shared publications
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Sex differences in somatotrope response to fasting: biphasic responses in male mice
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 16 shared publications
Noor Akhter
University of Arkansas for Medical Sciences
13 shared publications
In database
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity
- Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility
- Adipocyte Versus Pituitary Leptin in the Regulation of Pituitary Hormones: Somatotropes Develop Normally in the Absence of Circulating Leptin
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
Showing 5 of 13 shared publications
Mohsin Syed
University of Arkansas for Medical Sciences
12 shared publications
In database
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity
- Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity
Showing 5 of 12 shared publications
Stephanie D. Byrum
Arkansas Children's Hospital
12 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
Showing 5 of 12 shared publications
Linda Hardy
University of Arkansas for Medical Sciences
9 shared publications
In database
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 9 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
9 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
Melody Allensworth
University of Arkansas for Medical Sciences (US)
8 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
- Functional defects in mice somatotropes caused by ablation of leptin receptors is reversed, in vitro, by stimulation with Ghrelin
- MON-482 Sex-Dependent Biphasic Response by Somatotropes to Fasting and Loss of Leptin Signaling
- SAT-406 Deletion of Musashi in Gonadotropes Leads to Increased GnRHR Protein Levels and Gonadotrope Dysfunction
Showing 5 of 8 shared publications
Jewel Banik
Stanford University
8 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- SAT-284 Musashi Exerts Translational Control Within Anterior Pituitary Cells of the POU1F1 Lineage
Showing 5 of 8 shared publications
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