Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
W
William B. Mattes
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Senior Scientific Advisor
Also affiliated: Center for Food Safety and Applied Nutrition (2023–2024); Centre National de la Recherche Scientifique (1996); National Institutes of Health (1985–1988); United States Food and Drug Administration (2014–2026); Johns Hopkins University (1982–1983); University of Kansas (2005); University of Alberta (1988); Eli Lilly (United States) (2008); Pfizer (United States) (2004); Pfizer (United Kingdom) (2004); Mario Negri Institute for Pharmacological Research (1990); Critical Path Institute (2007–2010); Institut Gustave Roussy (1996); National Cancer Institute (1985–1988); Perry Point VA Medical Center (2012–2014)
34 h-index
96 pubs
3,901 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
William B. Mattes, Senior Scientific Advisor at the National Center for Toxicological Research, has a research focus that includes the mechanisms of DNA damage and the development and qualification of biomarkers for drug safety assessment. His work has investigated the DNA sequence selectivity of guanine-N7 alkylation by various chloroethylating agents, including nitrogen mustards and antitumor agents. This research delves into how these agents interact with specific DNA sequences, particularly at guanine bases.
Mattes has also contributed to the field of toxicogenomics and biomarker development. He has been involved in efforts to establish consensus practices for qualifying safety biomarkers for early drug development. This includes work related to renal biomarker qualification submissions and recommendations for biomarker identification and qualification in clinical proteomics. His collaborations at the National Center for Toxicological Research include work with Li Pang, Laura K. Schnackenberg, Katy S Papineau, and Lijun Ren.
With an h-index of 34 and nearly 100 publications, Mattes is recognized as a highly cited researcher. His recent activity indicates ongoing engagement in scientific inquiry, with his most recent publication in 2025.
Metrics
- h-index: 34
- Publications: 96
- Citations: 3,901
Positions
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Senior Scientific Advisor 2023–presentCenter for Food Safety and Applied Nutrition ORCID
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Senior Scientific Advisor publications 2014–2026National Center for Toxicological Research ORCID
Selected Publications
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Baseline proteomic biomarkers for predicting chemotherapy-induced cardiotoxicity in breast cancer patients (2026)
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Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development (2025)
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Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025)
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Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024)
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Metabolomics as a Truly Translational Tool for Precision Medicine (2021)
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Qualification of Safety Biomarkers for Application to Early Drug Development (2020)
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Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice (2020)
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Determination of structural factors affecting binding to mu, kappa and delta opioid receptors (2020)
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Recent advances in understanding the hepatotoxicity associated with protein kinase inhibitors (2020)
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Comprehensive Identification and Characterization of Human Secretome Based on Integrative Proteomic and Transcriptomic Data (2019)
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Abstract 17363: Inter-Individual Heterogeneity Among Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Response to Kinase Inhibitors (2018)
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Computational identification of structural factors affecting the mutagenic potential of aromatic amines: study design and experimental validation (2018)
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Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes (2018)
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Induced Pluripotent Stem Cell-Derived Cardiomyocytes: An In Vitro Model to Predict Tyrosine Kinase Inhibitor (TKI)-Induced Structural Cardiotoxicity (2017)
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Regulatory landscapes for biomarkers and diagnostic tests: Qualification, approval, and role in clinical practice (2017)
Collaboration Network
Top Collaborators
Xi Yang
RTI International (US)
12 shared publications
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Biomarkers of Tobacco Smoke Exposure
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
Showing 5 of 12 shared publications
Qiang Shi
National Center for Toxicological Research
8 shared publications
In database
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
- Translating Extracellular Microrna into Clinical Biomarkers for Drug-Induced Toxicity: from High-Throughput Profiling to Validation
- Circulating Mitochondrial Biomarkers for Drug-Induced Liver Injury
Showing 5 of 8 shared publications
Richard D. Beger
National Center for Toxicological Research
7 shared publications
In database
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Metabolomics as a Truly Translational Tool for Precision Medicine
- Circulating Mitochondrial Biomarkers for Drug-Induced Liver Injury
- Computational identification of structural factors affecting the mutagenic potential of aromatic amines: study design and experimental validation
- Determination of structural factors affecting binding to mu, kappa and delta opioid receptors
Showing 5 of 7 shared publications
Donna L. Mendrick
National Center for Toxicological Research
5 shared publications
In database
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Biomarkers of Tobacco Smoke Exposure
- Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis
- Translating Extracellular Microrna into Clinical Biomarkers for Drug-Induced Toxicity: from High-Throughput Profiling to Validation
- Circulating Mitochondrial Biomarkers for Drug-Induced Liver Injury
Lijun Ren
National Center for Toxicological Research
5 shared publications
In database
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
- Recent advances in understanding the hepatotoxicity associated with protein kinase inhibitors
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
Matthew White
University of Arkansas – Fort Smith (US)
4 shared publications
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
- Induced Pluripotent Stem Cell-Derived Cardiomyocytes: An In Vitro Model to Predict Tyrosine Kinase Inhibitor (TKI)-Induced Structural Cardiotoxicity
- Abstract 17363: Inter-Individual Heterogeneity Among Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Response to Kinase Inhibitors
Huixiao Hong
National Center for Toxicological Research
3 shared publications
In database
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis
James Greenhaw
National Center for Toxicological Research
3 shared publications
In database
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
Thomas Papoian
Center for Drug Evaluation and Research (US)
3 shared publications
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
- Induced Pluripotent Stem Cell-Derived Cardiomyocytes: An In Vitro Model to Predict Tyrosine Kinase Inhibitor (TKI)-Induced Structural Cardiotoxicity
Li Pang
National Center for Toxicological Research
3 shared publications
In database
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development
William H. Tolleson
National Center for Toxicological Research
2 shared publications
In database
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
Lei Guo
National Center for Toxicological Research
2 shared publications
In database
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
Dianke Yu
Qingdao University (CN)
2 shared publications
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
Si Chen
National Center for Toxicological Research
2 shared publications
In database
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
Baitang Ning
National Center for Toxicological Research
2 shared publications
In database
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Comprehensive Identification and Characterization of Human Secretome Based on Integrative Proteomic and Transcriptomic Data
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