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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Angus M. MacNicol
Federal Grant PI
High Impact
Professor
Also affiliated: Arkansas Children's Hospital (2002); Howard Hughes Medical Institute (1993); University of California, San Francisco (1993–1995); University of Arkansas Medical Center (2012–2019); University of Chicago (1994–2001)
Neurobiology & Developmental Science, College of Medicine
27 h-index
105 pubs
2,739 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Angus M. MacNicol's research investigates fundamental mechanisms of cellular development and gene regulation, with a particular focus on oocyte maturation and early embryonic development in Xenopus.
His work has explored the role of signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway, in regulating mRNA polyadenylation and translation during Xenopus oocyte maturation, as demonstrated by studies on the Mos mRNA and its connection to progesterone-induced maturation. MacNicol has also investigated the function of RNA-binding proteins, like Musashi, in controlling the temporal order of mRNA translation during these critical developmental stages. Furthermore, his research extends to the cellular response to stress, examining the accumulation of G-quadruplex DNA in the cytoplasm and its participation in stress granule assembly under oxidative stress conditions.
MacNicol holds a Professor position in Neurobiology & Developmental Science at the University of Arkansas for Medical Sciences. His scholarly contributions are reflected in an h-index of 27 and over 2,700 citations across more than 100 publications. He has served as a principal investigator on federal grants and collaborates extensively with colleagues at his institution, including Melanie C MacNicol, Gwen V. Childs, Angela K. Odle, and Alex Lagasse.
Metrics
- h-index: 27
- Publications: 105
- Citations: 2,739
Positions
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Professor publications 2002–2026University of Arkansas for Medical Sciences Neurobiology & Developmental Science, College of Medicine Institutional directory
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Professor and Vice Chair publications 2002–2026University of Arkansas for Medical Sciences Neuroscience ORCID
Selected Publications
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation (2026)
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ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation (2026)
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MassIVE MSV000102254 - ELAVL1 and ELAVL4 are required for Musashi1-dependent mRNA translational activation (2026)
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Maternal gene regulation in early vertebrate development NIH Principal Investigator
- Control of pituitary cell plasticity through regulated mRNA translation NIH Principal Investigator
- Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
- G-quadruplex DNA as a chemical signaling agent NIH Co-Investigator
- Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Arkansas Breast Cancer Research Program Principal Investigator
- RAF-1 REGULATION DURING CELL GROWTH AND DIFFERENTIATION NIH Principal Investigator
- MRNA translational Control of Cell Cycle Progression American Cancer Society, Inc. Principal Investigator
- Leptin Molecular Regulatory Mechanisms That Prevent Growth hormone Deficiency NIH Co-Principal Investigator
- MRNA TRANSLATIONAL REGULATION IN HUMAN OOCYTES NIH Principal Investigator
- Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes NIH Co-Principal Investigator
- Tropic Roles for Leptin in the Maturation of Somatotropes NIH Co-Principal Investigator
- Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
- Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids NIH Co-Investigator
- The Impact of Obesity on Somatotrope Function NIH Co-Principal Investigator
- Evaluation of Obesity and Physical Inactivity in the “Spit for the Cure” Participants Arkansas Breast Cancer Research Program Principal Investigator
Collaboration Network
Top Collaborators
Melanie C MacNicol
University of Arkansas for Medical Sciences
57 shared publications
In database
- The Importance of Leptin to Reproduction
- Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation.
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation
- Enforcing temporal control of maternal mRNA translation during oocyte cell‐cycle progression
Showing 5 of 57 shared publications
Gwen V. Childs
University of Arkansas for Medical Sciences
47 shared publications
In database
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Molecular Mechanisms of Pituitary Cell Plasticity
Showing 5 of 47 shared publications
Angela K. Odle
University of Arkansas for Medical Sciences
42 shared publications
In database
- The Importance of Leptin to Reproduction
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
Showing 5 of 42 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
30 shared publications
In database
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
Showing 5 of 30 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
23 shared publications
In database
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Sex differences in somatotrope response to fasting: biphasic responses in male mice
Showing 5 of 23 shared publications
Linda Hardy
University of Arkansas for Medical Sciences
19 shared publications
In database
- Enforcing temporal control of maternal mRNA translation during oocyte cell‐cycle progression
- Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation
- Ringo/Cyclin-dependent Kinase and Mitogen-activated Protein Kinase Signaling Pathways Regulate the Activity of the Cell Fate Determinant Musashi to Promote Cell Cycle Re-entry in Xenopus Oocytes
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- Neural stem and progenitor cell fate transition requires regulation of Musashi1 function
Showing 5 of 19 shared publications
Alex Lagasse
University of Arkansas for Medical Sciences
18 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 18 shared publications
Ana Rita Silva Moreira
University of Arkansas for Medical Sciences (US)
16 shared publications
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Sex differences in somatotrope response to fasting: biphasic responses in male mice
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 16 shared publications
Melody Allensworth‐James
University of Arkansas for Medical Sciences
13 shared publications
In database
- Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators
Showing 5 of 13 shared publications
Stephanie D. Byrum
Arkansas Children's Hospital
13 shared publications
In database
- Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 13 shared publications
Chad E. Cragle
Health and Human Development (2HD) Research Network (CM)
9 shared publications
- Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation.
- Musashi Protein-directed Translational Activation of Target mRNAs Is Mediated by the Poly(A) Polymerase, Germ Line Development Defective-2
- Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation
- Ringo/Cyclin-dependent Kinase and Mitogen-activated Protein Kinase Signaling Pathways Regulate the Activity of the Cell Fate Determinant Musashi to Promote Cell Cycle Re-entry in Xenopus Oocytes
- Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2
Showing 5 of 9 shared publications
Jewel Banik
Stanford University
9 shared publications
In database
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
Showing 5 of 9 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
9 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
- Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 9 shared publications
Megan R. Reed
Cancer Institute (WIA)
8 shared publications
In database
- Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
Showing 5 of 8 shared publications
Robert L. Eoff
Cancer Institute (WIA)
8 shared publications
In database
- Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models
- Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells
Showing 5 of 8 shared publications
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