Meenakshisundaram Balasubramaniam Institution Verified
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Assistant Professor
University of Arkansas for Medical Sciences
faculty
Research Areas
Biography and Research Information
OverviewAI-generated summary
Meenakshisundaram Balasubramaniam leads a research group at the University of Arkansas for Medical Sciences that investigates molecular mechanisms underlying neurodegenerative diseases and other age-associated conditions. His work has focused on identifying potential biomarkers and therapeutic targets for conditions such as Alzheimer's disease and glioblastoma.
Recent publications from Balasubramaniam's group include studies on the role of epidermal growth factor receptor inhibitors in glioblastoma, the use of glial fibrillary acidic protein as a biomarker for Alzheimer's disease, and the identification of intrinsically disordered proteins in aggregate proteomes as potential neurodegeneration biomarkers. His team has also explored the therapeutic potential of novel compounds, such as hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase agents for Alzheimer's disease, and small molecules for rescuing lysosomal autophagic failure in Alzheimer's disease.
Balasubramaniam collaborates with several researchers at the University of Arkansas for Medical Sciences, including Srinivas Ayyadevara, Robert J. Shmookler Reis, Akshatha Ganne, and Nirjal Mainali, with whom he has co-authored numerous publications. His research output includes 55 publications with 1,184 citations, and he holds an h-index of 22, designating him as a highly cited researcher.
Metrics
- h-index: 22
- Publications: 55
- Citations: 1,184
Selected Publications
- The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer’s disease (2026) DOI
- Zolpidem restores sleep and slows Alzheimer’s progression in a mouse model (2025) DOI
- When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025) DOI
- The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025) DOI
- Altered protein homeostasis in cardiovascular diseases contributes to Alzheimer’s-like neuropathology (2025) DOI
- Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025) DOI
- Metabolomic Profiling and Machine Learning Models for Tumor Classification in Patients with Recurrent IDH-Wild-Type Glioblastoma: A Prospective Study (2024) DOI
- Tools of Artificial Intelligence in the Improvement of Synaptic Impairment in Different Neurodegenerative Diseases (2024) DOI
- Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction (2024) DOI
- Epidermal Growth Factor Receptor Inhibitors in Glioblastoma: Current Status and Future Possibilities (2024) DOI
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024) DOI
- Alzheimer’s-specific brain amyloid interactome: Neural-network analysis of intra-aggregate crosslinking identifies novel drug targets (2023) DOI
- Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain (2023) DOI
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023) DOI
- In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration (2023) DOI
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