Igor P. Pogribny Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

◆ ARA Academy High Impact

Researcher

National Center for Toxicological Research

faculty

75 h-index 293 pubs 17,887 cited

Research Areas

Epigenetics and DNA Methylation Carcinogens and Genotoxicity Assessment Cancer-related molecular mechanisms research Liver Disease Diagnosis and Treatment Diet and metabolism studies Molecular Biology Techniques and Applications Meta-analysis and systematic reviews Pharmacological Effects and Toxicity Studies

Links

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OverviewAI-generated summary

Igor P. Pogribny's research investigates the molecular mechanisms underlying chemical carcinogenesis and the role of epigenetic alterations in disease development. His work focuses on understanding how environmental and occupational carcinogens induce changes in DNA methylation and gene expression, contributing to conditions such as hepatocellular carcinoma and non-alcoholic fatty liver disease.

Pogribny has published extensively on these topics, including studies utilizing mouse and rat models to examine the effects of specific diets and chemical exposures. His recent work has explored the impact of dietary interventions, such as methionine-supplemented and deficient diets, on epigenetic modifications in the liver. He has also assessed the effects of organic versus inorganic forms of arsenic and mercury in model organisms. Collaborating with researchers at the National Center for Toxicological Research, including Volodymyr Tryndyak and Frederick A. Beland, Pogribny has contributed to a significant body of work in molecular toxicology. His scholarly output is recognized by an h-index of 75 and over 17,000 citations, designating him as a highly cited researcher and an ARA Academy Fellow.

Metrics

h-index: 75
Publications: 293
Citations: 17,887

Selected Publications

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma (2025) DOI
Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025) DOI
Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025) DOI
A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024) DOI
Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023) DOI
Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023) DOI
Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023) DOI
Assessment of the effects of organic vs. inorganic arsenic and mercury in Caenorhabditis elegans (2022) DOI
Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma (2022) DOI
Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022) DOI
Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets (2022) DOI
Erratum to: Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis (2021) DOI
Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review (2021) DOI
The DEN and CCl<sub>4</sub>‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma (2021) DOI
Supplementation of Choline-Deficient Diet With Pterostilbene Attenuates Cancer Development and Epigenetic Dysregulation of Gene Expression in Rat Livers (2021) DOI

ARA Academy 2023 ARA Fellow

Dr. Pogribny is a distinguished scientist specializing in molecular toxicology and carcinogenesis. He earned his M.D. with honors from Ivano-Frankivsk National Medical University in Ukraine and a Ph.D. in Biochemistry/Oncology from Kyiv National Medical University. Since 2003, he has served as a research biologist and senior biomedical researcher at NCTR.

Policy Impact

Distinguished federal scientist at NCTR advancing understanding of chemical carcinogenesis, supporting the FDA's regulatory mission and public health protection from Arkansas.