Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-07
H
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Hayden Roys' research focuses on understanding the molecular mechanisms by which the parasite Leishmania major infects macrophages and influences host responses. Roys has investigated the role of hypoxia-inducible factor (HIF) signaling in macrophages during Leishmania major infection, particularly its impact on cellular function and the inflammatory response. Studies have explored how Leishmania infection induces macrophage production of vascular endothelial growth factor A in a HIF-dependent manner, and how HIF-α activation affects macrophage function and promotes lymphangiogenesis in murine models. Roys' work also examines transcriptional remodeling in macrophages within leishmanial lesions, revealing cellular heterogeneity and altered transcriptomic profiles at single-cell resolution. This research contributes to the understanding of host-pathogen interactions and the immune response to parasitic infections.
Metrics
- h-index: 4
- Publications: 20
- Citations: 123
Selected Publications
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during L. major infection and promote host defense to infection (2026)
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Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis 4267 (2025)
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Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376 (2025)
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Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis (2025)
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Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis (2025)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2025)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2024)
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Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs (2024)
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Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis (2024)
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Distinct lymphatic remodeling is associated with healing and non-healing murine cutaneous leishmaniasis (2023)
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Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions (2023)
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In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution (2022)
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Erratum for Weinkopff et al., “ Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner” (2022)
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HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection (2021)
Collaboration Network
Top Collaborators
Anne K. Bowlin
University of Arkansas for Medical Sciences
19 shared publications
In database
- Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
Showing 5 of 19 shared publications
Tiffany Weinkopff
University of Arkansas for Medical Sciences
18 shared publications
In database
- Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
Showing 5 of 18 shared publications
Lucy Fry
University of Arkansas for Medical Sciences
14 shared publications
In database
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
Showing 5 of 14 shared publications
Gopinath Venugopal
University of Arkansas for Medical Sciences
12 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
Showing 5 of 12 shared publications
Jordan T. Bird
University of Arkansas for Medical Sciences
10 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
Showing 5 of 10 shared publications
Stephanie D. Byrum
Arkansas Children's Hospital
9 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
Showing 5 of 9 shared publications
Charity L. Washam
University of Arkansas for Medical Sciences
8 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
- HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection
- In vivo reprogramming of murine host immune response genes following Leishmania major infection
Showing 5 of 8 shared publications
Alexx Weaver
University of Arkansas for Medical Sciences
4 shared publications
In database
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis
- Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis
- Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs
- Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis 4267
Humphrey Wanjala
University of Arkansas for Medical Sciences
3 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
Manjunath Bettadapura
University of Arkansas for Medical Sciences
3 shared publications
In database
- Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
Phillip Scott
University of Pennsylvania (US)
2 shared publications
- Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner
- Erratum for Weinkopff et al., “ Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner”
Steven Murdock
University of Arkansas for Medical Sciences
2 shared publications
In database
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- HIF-alpha Activation Impacts Macrophage Function During Murine Leishmania major Infection
Flavia Neto de Jesus
University of Arkansas for Medical Sciences
2 shared publications
In database
- Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
- Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376
Matheus Batista Heitor Carneiro
University of Arkansas for Medical Sciences (US)
2 shared publications
- Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
- Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376
Nathan C. Peters
University of Arkansas for Medical Sciences (US)
2 shared publications
- Dysregulated lymphatic remodeling promotes immunopathology during non-healing cutaneous leishmaniasis
- Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 4376
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