Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
K
Katy S Papineau
Researcher
Also affiliated: United States Food and Drug Administration (2022–2025)
Unknown Researcher
3 h-index
5 pubs
47 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Katy S Papineau's research focuses on understanding drug-induced liver injury (DILI) and other forms of cellular toxicity. She has investigated the mechanisms by which specific compounds, such as pexidartinib and the tire rubber antiozonant 6PPD-quinone, impact liver cells, particularly human hepatocytes. Her work has explored mitochondrial dysfunction as a key pathway leading to cell death in response to these agents, often at clinically relevant concentrations. Papineau also contributes to the development and application of advanced in vitro models, including liver-on-a-chip platforms, to study DILI and to measure relevant biomarkers. Her publications include studies on the co-culture of primary human hepatocytes and nonparenchymal liver cells, as well as proof-of-concept studies for predicting drug cardiotoxicity using induced pluripotent stem cell-derived cardiomyocytes. Papineau has collaborated with researchers at the National Center for Toxicological Research on multiple publications.
Metrics
- h-index: 3
- Publications: 5
- Citations: 47
Selected Publications
-
Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025)
-
Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025)
-
Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025)
-
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024)
-
Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022)
Collaboration Network
Top Collaborators
Lijun Ren
United States Food and Drug Administration
5 shared publications
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Laura K. Schnackenberg
National Center for Toxicological Research
5 shared publications
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Qiang Shi
National Center for Toxicological Research
4 shared publications
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Mark Avigan
Center for Drug Evaluation and Research (US)
2 shared publications
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Lorna Ewart
Emulate (United States) (US)
2 shared publications
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Li Pang
National Center for Toxicological Research
2 shared publications
In database
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
Xi Yang
Center for Drug Evaluation and Research (US)
2 shared publications
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
William B. Mattes
National Center for Toxicological Research
2 shared publications
In database
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
Gonçalo Gamboa da Costa
National Center for Toxicological Research
2 shared publications
In database
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Tucker A. Patterson
United States Food and Drug Administration
2 shared publications
In database
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Ayesha Arefin
National Center for Toxicological Research
1 shared publication
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Dustyn A. Barnette
United States Food and Drug Administration
1 shared publication
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Jessica J. Hawes
United States Food and Drug Administration (US)
1 shared publication
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Donna L. Mendrick
United States Food and Drug Administration
1 shared publication
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Janey Ronxhi
Emulate (United States) (US)
1 shared publication
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Similar Researchers
Based on overlapping research topics
Jessica Hawes Oliphant
National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection
Mitochondrial Function and Pathology
Pharmacological Effects and Toxicity Studies
Maria Espana-Pena
University of Arkansas at Fayetteville
Mitochondrial Function and Pathology
Disease Models, Animal
Molecular Biology Techniques and Applications
Shivangi Shrimali
National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection
Pharmacological Effects and Toxicity Studies
Disease Models, Animal
Vijayalaskshmi Varma
National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection
Mitochondrial Function and Pathology
Pharmacological Effects and Toxicity Studies
Ji‐Eun Seo
National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection
Pharmacological Effects and Toxicity Studies
Disease Models, Animal
Svetoslav Slavov
National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies
Disease Models, Animal
Molecular Biology Techniques and Applications