Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
J
Jesús Delgado‐Calle
Federal Grant PI
High Impact
Assistant Professor
Also affiliated: Universidad de Cantabria (2011–2017); Indiana University Hospital (2014–2020); Marqués de Valdecilla University Hospital (2011–2017); Fundación Marques de Valdecilla (2013); Richard L. Roudebush VA Medical Center (2014–2020); Instituto de Investigación Marqués de Valdecilla (2014–2017); Indiana University Indianapolis (2015–2020); Indiana University Melvin and Bren Simon Comprehensive Cancer Center (2017); Indiana University School of Medicine (2013–2020); Indiana University – Purdue University Indianapolis (2016–2020); Indiana University (2016–2020)
31 h-index
190 pubs
3,656 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jesús Delgado‐Calle's research focuses on the cellular and molecular mechanisms that regulate bone metabolism and health, particularly in the context of diseases like multiple myeloma. His work investigates the role of osteocytes, specialized bone cells, in mediating bone formation and destruction. He has explored the signaling pathways, such as Wnt/β-catenin, that influence bone anabolism and has examined the impact of factors like sclerostin on bone health.
His research has been supported by significant federal funding from the NIH/National Cancer Institute. Two grants totaling over $1.3 million have been awarded to him as PI to study the contribution of osteocytes to the musculoskeletal effects of multiple myeloma and to develop bone-targeted therapies for patients with this disease. Delgado‐Calle has a substantial publication record, with over 205 publications and an h-index of 31, indicating a high level of scholarly output and impact. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Hayley M. Sabol, Teresita Bellido, Sharmin Khan, and Aric Anloague, with whom he has co-authored numerous publications.
Metrics
- h-index: 31
- Publications: 190
- Citations: 3,656
Positions
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Assistant Professor 2020–presentUniversity of Arkansas for Medical Sciences Physiology and Cell Biology ORCID
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Assistant Research Professor 2016–2020Indiana University School of Medicine Department of Anatomy and Cell Biology ORCID
Selected Publications
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An enhancement of extrachromosomal circular DNA enrichment and amplification to address the extremely low overlap between replicates (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells (2026)
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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025)
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An Enhancement of Extrachromosomal Circular DNA Enrichment and Amplification to Address the Extremely Low Overlap Between Replicates (2025)
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Ex Vivo Model Systems of Cancer-Bone Cell Interactions (2025)
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2D and 3D In Vitro Co-culture for Cancer and Bone Cell Interaction Studies (2025)
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Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma (2025)
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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis (2025)
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Unlocking acid ceramidase: a new weapon against proteasome chemoresistance in myeloma (2025)
Federal Grants 2 $1,373,203 total
NIH
Contact PI
Jun 2025 - May 2027
Bone-Targeted Therapies to Improve Bone Health and Prevent Relapse in Multiple Myeloma
NIH
Contact PI
Mar 2017 - Jun 2028
Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma
Collaboration Network
Top Collaborators
Hayley M. Sabol
University of Arkansas for Medical Sciences
19 shared publications
In database
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- The multifunctional role of Notch signaling in multiple myeloma
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
Showing 5 of 19 shared publications
Aric Anloague
University of Arkansas for Medical Sciences
14 shared publications
In database
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- Osteocytes: New Kids on the Block for Cancer in Bone Therapy
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Showing 5 of 14 shared publications
Intawat Nookaew
University of Arkansas for Medical Sciences
11 shared publications
In database
- CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Showing 5 of 11 shared publications
Cody Ashby
University of Arkansas for Medical Sciences
10 shared publications
In database
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma
- Abstract 5672: Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
Showing 5 of 10 shared publications
Elena Ambrogini
Central Arkansas Veterans Healthcare System
10 shared publications
In database
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
Showing 5 of 10 shared publications
Sharmin Khan
University of Arkansas for Medical Sciences
9 shared publications
In database
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Showing 5 of 9 shared publications
Frank H. Ebetino
BioVinc (United States) (US)
9 shared publications
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Data from Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
Showing 5 of 9 shared publications
Carolina Schinke
University of Arkansas for Medical Sciences
9 shared publications
In database
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
Showing 5 of 9 shared publications
Manish Adhikari
University of Arkansas for Medical Sciences (US)
8 shared publications
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- Role of Osteocytes in Cancer Progression in the Bone and the Associated Skeletal Disease
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Showing 5 of 8 shared publications
Japneet Kaur
Winthrop Rockefeller Foundation
8 shared publications
In database
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
Showing 5 of 8 shared publications
Noriyoshi Kurihara
Indiana University – Purdue University Indianapolis (US)
7 shared publications
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- Osteocytes and Paget’s Disease of Bone
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
Showing 5 of 7 shared publications
Teresita Bellido
Central Arkansas Veterans Healthcare System
7 shared publications
In database
- The osteocyte as a signaling cell
- Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Wnt/β-catenin Signaling Controls Maxillofacial Hyperostosis
Showing 5 of 7 shared publications
Bethany C. Paxton
University of Arkansas for Medical Sciences
7 shared publications
In database
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
- Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
- Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
Showing 5 of 7 shared publications
C. Lowry Barnes
University of Arkansas for Medical Sciences
6 shared publications
In database
- Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
- A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma
- Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
- Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
Showing 5 of 6 shared publications
Peter I. Croucher
Garvan Institute of Medical Research (AU)
6 shared publications
- Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
- Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
- Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
- Additional file 1 of Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
Sharmin Khan
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Multiple Myeloma Research and Treatments
Cancer-related molecular mechanisms research
Dongzheng Gai
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Multiple Myeloma Research and Treatments
Cancer-related molecular mechanisms research
Aric Anloague
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
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Disease Mechanisms Research
Hayley M. Sabol
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Multiple Myeloma Research and Treatments
Disease Mechanisms Research
Wen Ling
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Multiple Myeloma Research and Treatments
Disease Mechanisms Research
Stavros C. Manolagas
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
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Receptor Mechanisms and Signaling