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Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-16
Biography and Research Information
OverviewAI-generated summary
Yuxi Li's research focuses on the metabolic and toxicological effects of various compounds, particularly cannabidiol (CBD), in biological systems. Li has investigated the impact of CBD and its metabolites on mouse and human Sertoli cells, examining transcriptomic changes and cellular senescence. Further studies have explored the metabolism and liver toxicity associated with CBD. Beyond CBD, Li's work includes investigating glycogen accumulation and its role in liver tumor initiation, as well as the mutagenicity and genotoxicity of specific chemical compounds in bacterial and human assays. Other research areas include the effects of EGF on human trophoblast cell invasion and the genetic insights from the Manchurian walnut genome related to lipid biosynthesis. Li has 73 publications, a h-index of 19, and 1,322 citations, collaborating extensively with researchers at the National Center for Toxicological Research.
Metrics
- h-index: 19
- Publications: 73
- Citations: 1,322
Selected Publications
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Mechanistic study of the cytotoxicity of cannabidiol and its metabolites in HepG2 cells (2025)
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Dual DNA-binding capability of Cdc13 coordinates with Ku to safeguard telomere integrity (2025)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025)
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025)
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Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025)
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Investigation of cannabidiol-induced cytotoxicity in human hepatic cells (2024)
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Metabolism and liver toxicity of cannabidiol (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells (2022)
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The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells (2022)
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In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells (2021)
Collaboration Network
Top Collaborators
Lei Guo
National Center for Toxicological Research
12 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 12 shared publications
Si Chen
National Center for Toxicological Research
11 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Showing 5 of 11 shared publications
Xilin Li
National Center for Toxicological Research
8 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
Showing 5 of 8 shared publications
Supratim Choudhuri
United States Food and Drug Administration (US)
7 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Showing 5 of 7 shared publications
Qiangen Wu
National Center for Toxicological Research
5 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
- 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells
Patrick Cournoyer
United States Food and Drug Administration (US)
5 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells
Nan Mei
National Center for Toxicological Research
5 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i>
Xilin Li
National Center for Toxicological Research
3 shared publications
In database
- Metabolism and liver toxicity of cannabidiol
- Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells
- Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i>
Montserrat Puig
United States Food and Drug Administration (US)
3 shared publications
- Metabolism and liver toxicity of cannabidiol
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
- 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells
Frederic Moulin
United States Food and Drug Administration (US)
3 shared publications
- Metabolism and liver toxicity of cannabidiol
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
- 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells
Jeremy Gingrich
United States Food and Drug Administration (US)
3 shared publications
- Metabolism and liver toxicity of cannabidiol
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
- 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells
Xilin Li
National Center for Toxicological Research
2 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells
Yuan Le
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
Ji‐Eun Seo
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Xiaoqing Guo
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
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