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Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
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2026-10-06
M
Michelle E. Bishop
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Also affiliated: United States Food and Drug Administration (1995–2026)
17 h-index
34 pubs
896 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Michelle E. Bishop's research focuses on toxicological studies, particularly investigating the genotoxicity and mutagenicity of various chemical compounds. Her work has involved extensive use of in vitro and in vivo models, including the Ames test and rodent studies, to assess the potential DNA damage and adverse health effects of substances like N-nitrosamines (NNK) and ortho-phthalaldehyde. Bishop has studied different exposure routes, such as nose-only inhalation, intraperitoneal injection, and oral gavage, to understand the toxicokinetics and genotoxic outcomes in male Sprague Dawley rats. Her research also explores the comparison of standard genotoxicity assays with organotypic cell cultures to better predict human health risks.
With an h-index of 17 and 51 total publications, Bishop has contributed to the field of toxicology. Her key collaborators include Robert H. Heflich, Matthew Bryant, Sherry M. Lewis, and Shu-Chieh Hu, all from the National Center for Toxicological Research, with whom she has co-authored multiple publications. Her work has been published in journals, with recent contributions in 2021 and upcoming work in 2024, 2025, and 2026, indicating continued activity in her research area.
Metrics
- h-index: 17
- Publications: 34
- Citations: 896
Selected Publications
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Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N ‐Nitrosamines (2026)
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions (2025)
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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
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90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)
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14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)
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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
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A Streamlined and High-Throughput Error-Corrected Next-Generation Sequencing Method for Low Variant Allele Frequency Quantitation (2019)
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Lifespan Kras mutation levels in lung and liver of B6C3F1 mice (2018)
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In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver (2016)
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In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver (2016)
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In vivo genotoxicity of estragole in male F 344 rats (2014)
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Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats (2014)
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Assessment by Ames test and comet assay of toxicity potential of polymer used to develop field-capable rapid-detection device to analyze environmental samples (2014)
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Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling (2013)
Collaboration Network
Top Collaborators
Mugimane G. Manjanatha
National Center for Toxicological Research
13 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
- Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
Showing 5 of 13 shared publications
Robert H. Heflich
National Center for Toxicological Research
10 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53‐haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC
Showing 5 of 10 shared publications
Lascelles E. Lyn‐Cook
National Center for Toxicological Research
9 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats
- In vivo genotoxicity of estragole in male F 344 rats
Showing 5 of 9 shared publications
Mason G. Pearce
National Center for Toxicological Research
8 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- In vivo genotoxicity of estragole in male F 344 rats
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
Showing 5 of 8 shared publications
Anane Aidoo
National Center for Toxicological Research (US)
8 shared publications
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats
Showing 5 of 8 shared publications
Kelly J. Davis
National Center for Toxicological Research
7 shared publications
In database
- In vivo genotoxicity of estragole in male F 344 rats
- In Vivo Alkaline Comet Assay and Enzyme-modified Alkaline Comet Assay for Measuring DNA Strand Breaks and Oxidative DNA Damage in Rat Liver
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
Showing 5 of 7 shared publications
Wei Ding
National Center for Toxicological Research (US)
6 shared publications
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- In vivo genotoxicity of estragole in male F 344 rats
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
Showing 5 of 6 shared publications
Roberta A. Mittelstaedt
National Center for Toxicological Research
6 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Showing 5 of 6 shared publications
Suzanne M. Morris
National Center for Toxicological Research (US)
5 shared publications
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK+/− human lymphoblastoid cells
- Phenolphthalein induces micronuclei in transgenic human lymphoblastoid cells
James T. MacGregor
Dermatology Consulting Services (US)
4 shared publications
- Three‐color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood
- Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes III. An Efficient Method of Monitoring Chromosomal Damage in the Beagle Dog
- Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells
- Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes IV: An Index of Chromosomal Damage in the Rhesus Monkey (Macaca mulatta)
Sharon D. Shelton
National Center for Toxicological Research
4 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- 17 ?-estradiol and not genistein modulateslacI mutant frequency and types of mutation induced in the heart of ovariectomized big blue rats treated with 7, 12-dimethylbenz[a]anthracene
- Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the livercII gene of transgenic big blue rats
Daniel R. Doerge
National Center for Toxicological Research
4 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Sherry M. Lewis
National Center for Toxicological Research
4 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53‐haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Olen E. Domon
National Center for Toxicological Research (US)
3 shared publications
- Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells
- Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK+/− human lymphoblastoid cells
- Phenolphthalein induces micronuclei in transgenic human lymphoblastoid cells
James J. Chen
National Center for Toxicological Research (US)
3 shared publications
- Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells
- Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK+/− human lymphoblastoid cells
- Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats
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