Sydnye L. Shuttleworth

Federal Grant PI

Researcher

UAMS
Last publication 2026 Last refreshed 2026-05-22

faculty

2 h-index 72 pubs 44 cited

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OverviewAI-generated summary

Sydnye L. Shuttleworth's research investigates therapeutic targets and molecular mechanisms in cancer and infectious diseases. Her work includes studying NEK2 as a therapeutic target in lymphoma and exploring T cell exhaustion in solid tumors, for which she received a $40,026 NIH/National Cancer Institute grant as PI. Shuttleworth also examines the role of specific compounds, such as 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives, as antibacterial agents against gram-positive bacteria.

Her research also extends to understanding metabolic plasticity in T cells within the context of glioblastoma and proteomic analysis of T cell exhaustion, including the DNA damage response. Shuttleworth collaborates with multiple researchers at the University of Arkansas for Medical Sciences, including Vijay Patel, Ying-Zhi Xu, Mason McCrury, and Kennith Swafford, with whom she shares 46 publications.

Metrics

  • h-index: 2
  • Publications: 72
  • Citations: 44

Selected Publications

  • 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response (2023)
    2 citations DOI OpenAlex
  • 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma (2023)
    1 citation DOI OpenAlex
  • Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma (2023)
    13 citations DOI OpenAlex
  • 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents (2021)
    25 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 1 $40,026 total

NIH/National Cancer Institute Contact PI Aug 2025 - Jul 2029

Leveraging the E3 Ligase RNF166 to Prevent T Cell Exhaustion in Solid Tumors

National Cancer Institute $40,026 F30

Collaboration Network

39 Collaborators 3 Institutions 1 Country

Top Collaborators

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