Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Biography and Research Information
OverviewAI-generated summary
Sydnye L. Shuttleworth's research investigates therapeutic targets and molecular mechanisms in cancer and infectious diseases. Her work includes studying NEK2 as a therapeutic target in lymphoma and exploring T cell exhaustion in solid tumors, for which she received a $40,026 NIH/National Cancer Institute grant as PI. Shuttleworth also examines the role of specific compounds, such as 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives, as antibacterial agents against gram-positive bacteria.
Her research also extends to understanding metabolic plasticity in T cells within the context of glioblastoma and proteomic analysis of T cell exhaustion, including the DNA damage response. Shuttleworth collaborates with multiple researchers at the University of Arkansas for Medical Sciences, including Vijay Patel, Ying-Zhi Xu, Mason McCrury, and Kennith Swafford, with whom she shares 46 publications.
Metrics
- h-index: 3
- Publications: 72
- Citations: 55
Positions
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Graduate Assistant publications 2021–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2026)
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743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2025)
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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392 Donor-intrinsic proteomic programs shape CAR-T cell persistence across a longitudinal killing assay (2025)
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Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)
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854 Protein homeostasis enables T cell differentiation potential and sustains TIL function in cancer (2024)
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319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024)
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929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells (2024)
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932 Defining the role for PCK2 in T-cell metabolic plasticity (2024)
Federal Grants 1 $40,602 total
NIH
Contact PI
Aug 2025 - Jul 2029
Leveraging the E3 Ligase RNF166 to Prevent T Cell Exhaustion in Solid Tumors
Collaboration Network
Top Collaborators
Brian Koss
University of Arkansas for Medical Sciences
15 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 15 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
11 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
Showing 5 of 11 shared publications
Lora J. Rogers
University of Arkansas for Medical Sciences
10 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
Showing 5 of 10 shared publications
Jessica L Kelliher
University of Arkansas for Medical Sciences
8 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
Showing 5 of 8 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
6 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
Showing 5 of 6 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
5 shared publications
In database
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response
Jacob L Edmondson
University of Arkansas for Medical Sciences
5 shared publications
In database
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments
- 691 ATF6 activation promotes ICB response in melanoma
Nicole E. Scharping
University of California San Diego (US)
5 shared publications
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
- 854 Protein homeostasis enables T cell differentiation potential and sustains TIL function in cancer
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Ananda W. Goldrath
University of California San Diego (US)
5 shared publications
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
- 854 Protein homeostasis enables T cell differentiation potential and sustains TIL function in cancer
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Aaron J. Storey
Arkana Laboratories
4 shared publications
In database
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
Alan J. Tackett
University of Arkansas for Medical Sciences
4 shared publications
In database
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence
Alexander Monell
University of California San Diego (US)
4 shared publications
- 854 Protein homeostasis enables T cell differentiation potential and sustains TIL function in cancer
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
- 743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
Stephanie D. Byrum
St. Jude Children's Research Hospital
3 shared publications
In database
- Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
Latambria Hampton
University of Arkansas for Medical Sciences
3 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
Dennis Province
University of Arkansas for Medical Sciences
3 shared publications
In database
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
- Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion
- 277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion
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