Laura Ewing
Staff Fellow
Also affiliated: Center for Food Safety and Applied Nutrition (2012–2022); United States Food and Drug Administration (2012–2022); Children's Hospital of Philadelphia (2020); University of Pennsylvania (2020)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Laura Ewing's research investigates the toxicological and pharmacological effects of cannabis and its extracts, particularly focusing on cannabidiol (CBD). Her work utilizes various animal models, including mice and rabbits, to study these effects. Recent publications by Ewing and collaborators examine the impacts of proton and oxygen ion irradiation on cardiovascular function in rabbits and explore methods for assessing intestinal permeability in rodent models following radiation injury. She also employs comparative genomic analyses and zebrafish infectivity studies to characterize microbial strains, such as Cronobacter sakazakii and Salmonella enterica, originating from food sources. Ewing's research network includes key collaborators from the University of Arkansas for Medical Sciences, such as Igor Koturbash, Charles M. Skinner, Martin Hauer‐Jensen, and Rupak Pathak, with whom she has co-authored multiple publications. Her scholarship metrics include an h-index of 17 with 60 total publications and 995 total citations.
Metrics
- h-index: 17
- Publications: 60
- Citations: 1,040
Positions
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Staff Fellow 2021–presentNational Center for Toxicological Research Biochemical Toxicology ORCID
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Staff Fellow publications 2016–2024University of Arkansas for Medical Sciences ORCID
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Natural State Genomics 2021ORCID
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Post-doctoral Fellow 2020–2021University of Arkansas for Medical Sciences Biochemistry and Molecular Biology ORCID
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Graduate Assistant 2016–2020University of Arkansas for Medical Sciences Pharmacology and Toxicology ORCID
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Research Assistant 2014–2016University of Arkansas for Medical Sciences Pharmacology and Toxicolody ORCID
Selected Publications
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
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Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024)
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Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese (2022)
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Methods for induction and assessment of intestinal permeability in rodent models of radiation injury (2022)
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Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration (2020)
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Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation (2020)
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Green Tea Extract as a Safe and Effective Dietary Supplement: Lessons Learned from Mice (2020)
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Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome (2020)
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Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract (2020)
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The Development and Characterization of an scFv-Fc Fusion–Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse (2020)
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Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome (2020)
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The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse (2019)
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Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration (2019)
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Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model (2019)
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Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice (2019)
Collaboration Network
Top Collaborators
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
Showing 5 of 16 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
Showing 5 of 15 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
Showing 5 of 12 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Showing 5 of 9 shared publications
- MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives
Showing 5 of 7 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 7 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 7 shared publications
- The Development and Characterization of an scFv-Fc Fusion–Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse
- Going small to beat the high
- Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse
- The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse
- Anti‐Methamphetamine Antibody Gene Therapy Protects Against Some METH‐Induced Inflammation
Showing 5 of 6 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 6 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 6 shared publications
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
- Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
Showing 5 of 6 shared publications
- The Development and Characterization of an scFv-Fc Fusion–Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
- Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse
- The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse
- Anti‐Methamphetamine Antibody Gene Therapy Ameliorates Methamphetamine‐induced Locomotor Effects in Mice for 8 Months after a Single Treatment
- The Development and Characterization of an scFv-Fc Fusion–Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
- Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse
- The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse
- Anti‐Methamphetamine Antibody Gene Therapy Ameliorates Methamphetamine‐induced Locomotor Effects in Mice for 8 Months after a Single Treatment
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains
- Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives
- Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome
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