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Presence Current · Arkansas
Last published 2025
Sources OpenAlex · ORCID
Refreshed 2026-08-15

Charles M. Skinner

Researcher

Also affiliated: Arkansas Children's Hospital (2024); The University of Texas at San Antonio Health Science Center (2008–2013); Arkansas Children's Nutrition Center (2006); Arkansas Department of Health (2019)

Faculty Researcher

14 h-index 46 pubs 923 cited

  • Animals
  • Mice
  • Male
  • Mice, Inbred C57BL
  • Cannabis
  • Plant Extracts
  • Liver
  • Humans
  • Cannabidiol
  • Chemical and Drug Induced Liver Injury
  • Methionine
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Gastrointestinal Microbiome
  • Female

Biography and Research Information

OverviewAI-generated summary

Charles M. Skinner's research investigates the toxicological and pharmacological effects of cannabis-derived compounds, particularly cannabidiol (CBD), utilizing both animal models and human-relevant in vitro systems. His work has explored inter-strain variability in mouse responses to CBD-rich cannabis extracts and employed a human quad liver-on-chip system to bridge the gap between animal and human studies in toxicology and pharmacology. Skinner has also examined the effects of space-relevant radiation, specifically proton and oxygen ion irradiation, on cardiovascular function in rabbits and the intestinal one-carbon metabolism pathway and microbiome in mice. His research extends to assessing cytogenetic and epigenetic aberrations in peripheral lymphocytes, as demonstrated in studies of the Marshallese population in northwest Arkansas.

Skinner's scholarly output includes 46 publications with approximately 900 citations, and he holds an h-index of 14. He has established a network of collaborators at the University of Arkansas for Medical Sciences, including Igor Koturbash, Laura Ewing, Reid D. Landes, and Martin Hauer-Jensen, with whom he has co-authored multiple publications. His recent work spans from 2022 to 2025, indicating continued activity in his research areas.

Metrics

  • h-index: 14
  • Publications: 46
  • Citations: 923

Selected Publications

  • Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
    Radiation Research DOI OpenAlex
  • Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
    Drug and Chemical Toxicology 3 citations DOI OpenAlex
  • Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024)
    Food and Chemical Toxicology 2 citations DOI OpenAlex
  • Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model (2023)
    Life Sciences in Space Research 5 citations DOI OpenAlex
  • Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese (2022)
    International Journal of Radiation Biology 10 citations DOI OpenAlex
  • Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration (2020)
    International Journal of Molecular Sciences 14 citations DOI OpenAlex
  • Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation (2020)
    International Journal of Radiation Oncology*Biology*Physics 14 citations DOI OpenAlex
  • Green Tea Extract as a Safe and Effective Dietary Supplement: Lessons Learned from Mice (2020)
    Current Developments in Nutrition 2 citations DOI OpenAlex
  • Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome (2020)
    Current Developments in Nutrition DOI OpenAlex
  • Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract (2020)
    Journal of Dietary Supplements 35 citations DOI OpenAlex
  • Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome (2020)
    American Journal of Physiology-Gastrointestinal and Liver Physiology 25 citations DOI OpenAlex
  • Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration (2019)
    Molecules 36 citations DOI OpenAlex
  • Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma (2019)
    Carcinogenesis DOI OpenAlex
  • Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O) (2019)
    Life Sciences in Space Research 16 citations DOI OpenAlex
  • Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model (2019)
    Molecules 159 citations DOI OpenAlex

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Collaboration Network

38 Collaborators 14 Institutions 1 Country

Top Collaborators

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