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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-06
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Stephanie D. Byrum
High Impact
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Also affiliated: Arkansas Children's Hospital (2020–2023); St. Jude Children's Research Hospital (2025–2026); Johns Hopkins University (2013); University of California, Los Angeles (2022); University of Arkansas Medical Center (2010–2024); Johns Hopkins Medicine (2013); Skive Hospital (2024); Winthrop Rockefeller Foundation (2021); Banner MD Anderson Cancer Center (2024); UCLA Jonsson Comprehensive Cancer Center (2022); Arkansas Children's Research Institute (2018–2026); Penn State Milton S. Hershey Medical Center (2013)
34 h-index
297 pubs
4,669 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Stephanie D. Byrum's research focuses on understanding molecular mechanisms underlying cellular processes and disease, with a particular emphasis on proteomics and epigenetics. Her work has investigated the role of DNA methylation on N6-adenine in mammalian embryonic stem cells and explored how phase separation contributes to aberrant chromatin looping and cancer development. Byrum has also been involved in developing and applying methods for proteomic analysis, including the ChAP-MS technique for identifying proteins and histone posttranslational modifications at specific genomic loci and a CRISPR-based approach for proteomic analysis of single genomic loci. She developed proteiNorm, a tool for normalization and analysis of protein quantification data. Her research group at the University of Arkansas for Medical Sciences collaborates with several faculty members, including Samuel G. Mackintosh (24 shared publications), Alan J. Tackett (17 shared publications), Charity L. Washam (16 shared publications), and Ricky D. Edmondson (12 shared publications). Byrum's scholarly output includes 296 publications with over 4,649 citations, and she holds an h-index of 34, designating her as a highly cited researcher.
Metrics
- h-index: 34
- Publications: 297
- Citations: 4,669
Selected Publications
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during <i>L. major</i> infection and promote host defense to infection (2026)
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Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Rescue of Angiopoietin‐2 Inhibits Proliferation of Lymphatic Malformation Endothelial Cells (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication (2025)
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Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells (2025)
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Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025)
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Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2025)
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<i>BRCA1</i> influences whole body metabolism in humanized mice (2025)
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Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis (2025)
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HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
Collaboration Network
Top Collaborators
Alan J. Tackett
University of Arkansas for Medical Sciences
83 shared publications
In database
- DNA methylation on N6-adenine in mammalian embryonic stem cells
- Phase separation drives aberrant chromatin looping and cancer development
- ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth
- Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy
- ChAP-MS: A Method for Identification of Proteins and Histone Posttranslational Modifications at a Single Genomic Locus
Showing 5 of 83 shared publications
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
64 shared publications
In database
- DNA methylation on N6-adenine in mammalian embryonic stem cells
- Phase separation drives aberrant chromatin looping and cancer development
- ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- Indicators of responsiveness to immune checkpoint inhibitors
Showing 5 of 64 shared publications
Charity L. Washam
University of Arkansas for Medical Sciences
39 shared publications
In database
- Multi-omics data integration considerations and study design for biological systems and disease
- Identification of PTHrP(12-48) as a Plasma Biomarker Associated with Breast Cancer Bone Metastasis
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
Showing 5 of 39 shared publications
Aaron J. Storey
University of Arkansas for Medical Sciences
28 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
Showing 5 of 28 shared publications
Jordan T. Bird
University of Arkansas for Medical Sciences
20 shared publications
In database
- Multi-omics data integration considerations and study design for biological systems and disease
- Differences in cell death in methionine versus cysteine depletion
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
Showing 5 of 20 shared publications
Allen Gies
University of Arkansas for Medical Sciences
20 shared publications
In database
- Multi-omics data integration considerations and study design for biological systems and disease
- Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer
- Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
Showing 5 of 20 shared publications
Nathan L. Avaritt
University of Arkansas for Medical Sciences
16 shared publications
In database
- A quantitative proteomic analysis of FFPE melanoma
- Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
- Misregulation of Rad50 expression in melanoma cells
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis
Showing 5 of 16 shared publications
Rick D. Edmondson
University of Arkansas for Medical Sciences
15 shared publications
In database
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data
- Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Exploiting Correlations between Protein Abundance and the Functional Status of <i>saeRS</i> and <i>sarA</i> To Identify Virulence Factors of Potential Importance in the Pathogenesis of <i>Staphylococcus aureus</i> Osteomyelitis
Showing 5 of 15 shared publications
Ricky D. Edmondson
University of Arkansas for Medical Sciences
14 shared publications
In database
- Phase separation drives aberrant chromatin looping and cancer development
- Indicators of responsiveness to immune checkpoint inhibitors
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Showing 5 of 14 shared publications
Anne K. Bowlin
University of Arkansas for Medical Sciences
13 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- Formula Diet Alters the Ileal Metagenome and Transcriptome at Weaning and during the Postweaning Period in a Porcine Model
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Neonatal Diet Impacts Circulatory miRNA Profile in a Porcine Model
- Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model
Showing 5 of 13 shared publications
Gang Greg Wang
University of North Carolina at Chapel Hill (US)
13 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 13 shared publications
Duah Alkam
University of Arkansas for Medical Sciences
12 shared publications
In database
- Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
- Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics
- An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy
- One-pot method for preparing DNA, RNA, and protein for multiomics analysis
- Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy
Showing 5 of 12 shared publications
Ling Cai
Duke University (US)
11 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 11 shared publications
Sean D. Taverna
Johns Hopkins University
10 shared publications
In database
- ChAP-MS: A Method for Identification of Proteins and Histone Posttranslational Modifications at a Single Genomic Locus
- A CRISPR-based approach for proteomic analysis of a single genomic locus
- A PWWP Domain-Containing Protein Targets the NuA3 Acetyltransferase Complex via Histone H3 Lysine 36 trimethylation to Coordinate Transcriptional Elongation at Coding Regions
- Purification of a specific native genomic locus for proteomic analysis
- A Noncanonical Bromodomain in the AAA ATPase Protein Yta7 Directs Chromosomal Positioning and Barrier Chromatin Activity
Showing 5 of 10 shared publications
Gopinath Venugopal
University of Arkansas for Medical Sciences
10 shared publications
In database
- In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution
- HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection
- Both the Infection Status and Inflammatory Microenvironment Induce Transcriptional Remodeling in Macrophages in Murine Leishmanial Lesions
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- HIF-alpha Activation Impacts Macrophage Function During Murine <em>Leishmania major</em> Infection
Showing 5 of 10 shared publications
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