Xuan Zhang

OverviewAI-generated summary

Xuan Zhang's research focuses on the pharmacological effects and toxicological mechanisms of various compounds, particularly in the context of cardiovascular health, neurological pathways, and potential therapeutic applications. Zhang has investigated the protective effects of natural compounds like 1,8-cineole and neferine against cardiac injury, examining their roles in inhibiting oxidative stress, endoplasmic reticulum stress, and activating signaling pathways such as SIRT1/Nrf2/HO-1. Further research has explored the impact of compounds like cepharanthine and escin on cellular processes and disease models, including potential applications in lung adenocarcinoma therapy and amelioration of depressive-like behaviors in rats by modulating specific signaling pathways like BDNF/TrkB/CREB and TLR4/MyD88/NF-κB.

Additional research by Zhang includes the analysis of pesticide residues in agricultural products using advanced mass spectrometry techniques, and the identification of natural compounds as inhibitors of specific biological targets, such as TMEM16A. Zhang's work also encompasses meta-analyses of drug effects, including a study on biologic TNF-α inhibitors for severe skin reactions. With an h-index of 25 and over 2,200 citations across 79 publications, Zhang's research contributes to the understanding of molecular mechanisms underlying disease and the development of potential interventions. Zhang leads a research group and collaborates with colleagues at the National Center for Toxicological Research, including Fang Liu, Tucker A. Patterson, John Talpos, and Leah E. Latham.

Metrics

• h-index: 25
• Publications: 79
• Citations: 2,271