F
Frederick A. Beland Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Chemist
faculty
70 h-index
499 pubs
19,026 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Frederick A. Beland is a research chemist at the National Center for Toxicological Research. His research program focuses on the assessment of chemical safety, including the investigation of carcinogenicity, genotoxicity, and other toxicological endpoints. He has published extensively on these topics, with a significant body of work examining the effects of various chemicals on biological systems.
Beland's recent work includes studies on the carcinogenicity of compounds such as aspartame, methyleugenol, and isoeugenol, as well as the toxicity of polyethylene glycols in rats. He has also investigated the effects of cannabidiol and its metabolites on mouse and human cells, and the impact of inorganic arsenic on neuronal development in zebrafish. His research also extends to understanding the molecular mechanisms of diet-induced liver disease in mice, including DNA methylation and gene expression alterations, and lipidomic profiling of hepatic fatty acid composition. Furthermore, he has explored alternative skin barrier models for dermal absorption studies.
With a career marked by extensive publication and high citation counts (h-index: 70, total citations: 18,948), Beland is recognized as a highly cited researcher. He actively leads a research group and collaborates with colleagues at the National Center for Toxicological Research, including Volodymyr Tryndyak and Igor P. Pogribny, with whom he shares a substantial number of publications.
Metrics
- h-index: 70
- Publications: 499
- Citations: 19,026
Selected Publications
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters (2025)
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite (2025)
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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
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Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development (2025)
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Flow cytometric analysis of the SARS coronavirus 2 antibodies in human plasma (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
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Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Polycyclic Aromatic Hydrocarbons, Methylated Polycyclic Aromatic Hydrocarbons, and Polycyclic Azaaromatic Compounds (2023)
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Parallel evaluation of alternative skin barrier models and excised human skin for dermal absorption studies in vitro (2023)
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Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
Collaboration Network
Top Collaborators
Volodymyr Tryndyak
National Center for Toxicological Research
27 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
Showing 5 of 27 shared publications
Igor P. Pogribny
National Center for Toxicological Research
25 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 25 shared publications
Aline de Conti
19 shared publications
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 19 shared publications
Kostiantyn Dreval
Simon Fraser University (CA)
19 shared publications
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 19 shared publications
Orish Ebere Orisakwe
18 shared publications
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 18 shared publications
Sharon A. Ross
18 shared publications
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 18 shared publications
Gonçalo Gamboa da Costa
National Center for Toxicological Research
7 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid
Showing 5 of 7 shared publications
Rose Willett
National Center for Toxicological Research
7 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 7 shared publications
Mark Avigan
United States Food and Drug Administration (US)
5 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Ivan Rusyn
Texas A&M University (US)
5 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Jia‐Long Fang
National Center for Toxicological Research
4 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite
- Flow cytometric analysis of the SARS coronavirus 2 antibodies in human plasma
Michelle M. Vanlandingham
Biochemical Society
4 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits
Robert P. Felton
National Center for Toxicological Research
4 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Parallel evaluation of alternative skin barrier models and excised human skin for dermal absorption studies in vitro
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Suresh K. Nagumalli
National Center for Toxicological Research
4 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite
M. Matilde Marques
Centre International de Recherche sur le Cancer (FR)
3 shared publications
- Carcinogenicity of aspartame, methyleugenol, and isoeugenol
- Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine
- Polycyclic Aromatic Hydrocarbons, Methylated Polycyclic Aromatic Hydrocarbons, and Polycyclic Azaaromatic Compounds
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