Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
F
Frederick A. Beland
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Division of Biochemical Toxicology
Also affiliated: Centers for Disease Control and Prevention (2005); Roswell Park Comprehensive Cancer Center (2008); National Institutes of Health (1994–2008); Environmental Protection Agency (1981); University of Minnesota (2002); Fisheries and Oceans Canada (2000); United States Food and Drug Administration (1980–2026); Electric Power Research Institute (1998); University of Rhode Island (2003); Soochow University (1978); University of Utah (1991); Montana State University (1973–1977); The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (1986); University of Chicago (1976–1978); NYU Langone Health (2002); Orszagos Kornyezetegeszsegugyi Intezet (2005); Minneapolis VA Medical Center (2002); National Cancer Institute (1994–2008); Food and Drug Administration (2012); National Center for Epidemiology (2005); Centre international de recherche sur le cancer (2023); Instituto Superior Técnico (1994–2012); Space Sciences Laboratory (1980); Centro de Química Estrutural (1994–2012); Universidade Técnica de Lisboa (2008–2012); The Ohio State University (1986); New York University (2002); Universidade Nova de Lisboa (2008–2010); University of California, Berkeley (1980–2018)
71 h-index
498 pubs
19,281 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Frederick A. Beland's research focuses on the toxicological properties of various chemical compounds and their effects on biological systems, with a particular emphasis on DNA adduct formation. He has investigated the metabolic activation and DNA adducts of aromatic amines and nitroaromatic hydrocarbons, as well as the formation and persistence of arylamine DNA adducts in vivo. His work includes studies on the DNA adduct formation from acrylamide via its conversion to glycidamide in mice, and the identification of benzo[a]pyrene-nucleic acid derivatives in vivo.
Beland has also conducted toxicological reviews of specific substances, including malachite green and aloe barbadensis (Miller), aloe vera. His research interests extend to the relationship between alcohol consumption and ethyl carbamate, and the molecular mechanisms underlying cancer development, such as the transcriptional down-regulation of E-cadherin by epigenetic and microRNA alterations in human breast cancer cells. He has published extensively in this field, with a high h-index and a significant number of citations, and actively leads a research group at the National Center for Toxicological Research, collaborating with several colleagues.
Metrics
- h-index: 71
- Publications: 498
- Citations: 19,281
Positions
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Division of Biochemical Toxicology 1989–presentNational Center for Toxicological Research Division of Biochemical Toxicology ORCID
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Research Chemist 1976–presentNational Center for Toxicological Research ORCID
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Deputy Director 1985–1986National Center for Toxicological Research Division of Biochemical Toxicology, ORCID
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NIH Postdoctoral Fellow 1975–1976University of Chicago Ben May Laboratory ORCID
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Research Associate 1974–1975University of Chicago Ben May Laboratory ORCID
Selected Publications
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters (2025)
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite (2025)
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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
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Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development (2025)
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Flow cytometric analysis of the SARS coronavirus 2 antibodies in human plasma (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
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Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Polycyclic Aromatic Hydrocarbons, Methylated Polycyclic Aromatic Hydrocarbons, and Polycyclic Azaaromatic Compounds (2023)
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Parallel evaluation of alternative skin barrier models and excised human skin for dermal absorption studies in vitro (2023)
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Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
Collaboration Network
Top Collaborators
Igor P. Pogribny
National Center for Toxicological Research
61 shared publications
In database
- E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
- DNA hypomethylation in the origin and pathogenesis of human diseases
- Role of ferritin alterations in human breast cancer cells
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
Showing 5 of 61 shared publications
Volodymyr Tryndyak
National Center for Toxicological Research
47 shared publications
In database
- E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
- Role of ferritin alterations in human breast cancer cells
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Down‐regulation of the microRNAs miR‐34a, miR‐127, and miR‐200b in rat liver during hepatocarcinogenesis induced by a methyl‐deficient diet
Showing 5 of 47 shared publications
Gonçalo Gamboa da Costa
National Center for Toxicological Research
24 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
Showing 5 of 24 shared publications
M. Matilde Marques
University of Lisbon (PT)
24 shared publications
- Alcohol consumption and ethyl carbamate
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure
- Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts
- Synthesis, Characterization, and Quantitation of a 4-Aminobiphenyl−DNA Adduct Standard
Showing 5 of 24 shared publications
Daniel R. Doerge
National Center for Toxicological Research
23 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
- Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure
Showing 5 of 23 shared publications
Ivan Rusyn
Texas A&M University (US)
20 shared publications
- Alcohol consumption and ethyl carbamate
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Application of the key characteristics of carcinogens in cancer hazard identification
- Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
Showing 5 of 20 shared publications
Mona I. Churchwell
National Center for Toxicological Research
20 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Synthesis and Characterization of N-Demethylated Metabolites of Malachite Green and Leucomalachite Green
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans
Showing 5 of 20 shared publications
Aline de Conti
National Center for Toxicological Research (US)
18 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Effect of methionine‐deficient and methionine‐supplemented diets on the hepatic one‐carbon and lipid metabolism in mice
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
Showing 5 of 18 shared publications
Robert H. Heflich
National Center for Toxicological Research
16 shared publications
In database
- The orientation of the nitro substituent predicts the direct-acting bacterial mutagenicity of nitrated polycyclic aromatic hydrocarbons
- The In Vitro Metabolic Activation of Nitro Polycyclic Aromatic Hydrocarbons
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- Rapid isolation, hydrolysis and chromatography of formaldehyde-modified DNA
- Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green
Showing 5 of 16 shared publications
Linda S. Von Tungeln
National Center for Toxicological Research
14 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats
- The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results
Showing 5 of 14 shared publications
Jia‐Long Fang
National Center for Toxicological Research
14 shared publications
In database
- Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan
- Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
- Effect of triclosan, triclocarban, 2,2′,4,4′-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis
- Quantification of Etheno-DNA Adducts Using Liquid Chromatography, On-Line Sample Processing, and Electrospray Tandem Mass Spectrometry
- Long-Term Exposure to Zidovudine Delays Cell Cycle Progression, Induces Apoptosis, and Decreases Telomerase Activity in Human Hepatocytes
Showing 5 of 14 shared publications
Sharon A. Ross
National Cancer Institute (US)
11 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Down‐regulation of the microRNAs miR‐34a, miR‐127, and miR‐200b in rat liver during hepatocarcinogenesis induced by a methyl‐deficient diet
- Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
- Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl‐deficient diet
Showing 5 of 11 shared publications
Peter P. Fu
National Center for Toxicological Research (US)
11 shared publications
- The orientation of the nitro substituent predicts the direct-acting bacterial mutagenicity of nitrated polycyclic aromatic hydrocarbons
- The In Vitro Metabolic Activation of Nitro Polycyclic Aromatic Hydrocarbons
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- Metabolism of the mutagenic environmental pollutant, 6-nitrobenzo[a]pyrene: Metabolic activation via ring oxidation
Showing 5 of 11 shared publications
Fred F. Kadlubar
National Center for Toxicological Research (US)
10 shared publications
- Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay
- Chemical Properties of Ultimate Carcinogenic Metabolites of Arylamines and Arylamides
- In vitro reaction of the carcinogen, N-hydroxy-2-naphthylamine, with DNA at the C-8 and N2 atoms of guanine and at the N6 atom of adenine
- Characterization of DNA adducts of the carcinogen N-methyl-4-aminoazobenzene in vitro and in vivo
- DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo
Showing 5 of 10 shared publications
Paul C. Howard
Center for Environmental Health
9 shared publications
In database
- Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan
- Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by rat intestinal bacteria
- The In Vitro Metabolic Activation of Nitro Polycyclic Aromatic Hydrocarbons
- The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures
- 1-nitrosopyrene: An intermediate in the metabolic activation of 1-nitropyrene to a mutagen in Salmonella typhimurium TA1538
Showing 5 of 9 shared publications
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