G
Gonçalo Gamboa da Costa Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
faculty
31 h-index
100 pubs
2,778 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Gonçalo Gamboa da Costa's research focuses on the toxicological evaluation of various substances and the development of preclinical models for disease states. His work has investigated the effects of compounds such as high-molecular-weight polyethylene glycols and brominated vegetable oil in Sprague Dawley rats, as well as the renal toxicity of melamine and cyanuric acid, considering the influence of urinary pH. He has also explored the impact of coadministering black cohosh extract and risedronate on bone health in an ovariectomized rat model.
In addition to direct toxicological studies, Dr. Gamboa da Costa has contributed to the development and application of preclinical models. This includes work on diet-induced nonalcoholic fatty liver disease in Collaborative Cross mice, examining lipidomic profiles of hepatic esterified fatty acid composition. He has also been involved in creating a preclinical model of severe nonalcoholic steatohepatitis (NASH)-like liver injury through chronic administration of a high-fat and high-sucrose diet in mice. His research also touches upon considerations for animal microphysiological systems and the 3Rs (Replacement, Reduction, Refinement) in drug development, as noted in a 2025 publication.
With an h-index of 31 and over 2,760 citations from 98 publications, Dr. Gamboa da Costa is recognized as a highly cited researcher. He leads a research group and collaborates with several colleagues at the National Center for Toxicological Research, including Frederick A. Beland, Michelle M. Vanlandingham, Kellie A. Woodling, and Volodymyr Tryndyak.
Metrics
- h-index: 31
- Publications: 100
- Citations: 2,778
Selected Publications
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Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters (2025)
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Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025)
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025)
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Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
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Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats (2022)
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Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs (2022)
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Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats (2022)
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Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid (2021)
Collaboration Network
Top Collaborators
Frederick A. Beland
National Center for Toxicological Research
7 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid
Showing 5 of 7 shared publications
Michelle M. Vanlandingham
Biochemical Society
3 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits
Kellie A. Woodling
United States Food and Drug Administration
3 shared publications
In database
- Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Mark Avigan
Center for Drug Evaluation and Research (US)
3 shared publications
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Linda S. Von Tungeln
National Center for Toxicological Research
2 shared publications
In database
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
- Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid
Cristina C. Jacob
National Center for Toxicological Research (US)
2 shared publications
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
- Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid
Greg R. Olson
National Center for Toxicological Research
2 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid
Robert P. Felton
National Center for Toxicological Research
2 shared publications
In database
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
Richard D. Beger
National Center for Toxicological Research
2 shared publications
In database
- Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Suresh K. Nagumalli
National Center for Toxicological Research
2 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Rose Willett
National Center for Toxicological Research
2 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Volodymyr Tryndyak
National Center for Toxicological Research
2 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Ivan Rusyn
Texas A&M University (US)
2 shared publications
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Igor P. Pogribny
National Center for Toxicological Research
2 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Luísa Camacho
National Center for Toxicological Research
2 shared publications
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits
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