Maria Almeida

Federal Grant PI High Impact

Professor

UAMS

Last publication 2025 Last refreshed 2026-05-22

faculty

schullermaria@uams.edu

54 h-index 152 pubs 11,621 cited

Research Areas

Links

ORCID Google Scholar Lab Website Research Group

OverviewAI-generated summary

Maria Almeida's research program focuses on the cellular and molecular mechanisms underlying bone aging and the effects of estrogen deficiency on bone health. Her work investigates the roles of key cellular components and signaling pathways in bone remodeling, particularly concerning osteoblasts and osteoclasts.

Almeida has received significant federal funding to study these processes. Current NIH grants include support for investigating the different consequences of cellular aging in cortical versus cancellous bone, exploring the mechanisms that decrease bone formation with aging, and examining how estrogen antagonizes RANKL signaling in osteoclasts. These projects aim to elucidate pathways that contribute to age-related bone loss and identify potential therapeutic targets.

Her recent publications highlight her contributions to understanding the impact of mitochondrial function, reactive oxygen species, and NAD+ levels on bone cells during aging and estrogen deficiency. She has also published on refining the identification of mesenchymal cell types involved in bone formation and the molecular mechanisms regulating osteoclast gene expression. Almeida's scholarship metrics include an h-index of 54, with over 156 publications and 11,482 citations. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Charles A. O’Brien, Elena Ambrogini, Olivia Reyes‐Castro, and Hayley M. Sabol.

Metrics

h-index: 54
Publications: 152
Citations: 11,621

Selected Publications

IRE1 signaling in osteoprogenitors augments β-catenin activity and physiologic bone accrual (2026)

DOI OpenAlex
The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)

2 citations DOI OpenAlex
Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells (2025)

2 citations DOI OpenAlex
Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025)

6 citations DOI OpenAlex
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025)

4 citations DOI OpenAlex
CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024)

1 citation DOI OpenAlex
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice (2024)

10 citations DOI OpenAlex
Single cell RNA sequencing of mesenchymal populations from murine knees reveals distinct pathways altered in age-associated versus post-traumatic osteoarthritis (2024)

DOI OpenAlex
Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer (2024)

DOI OpenAlex
Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism (2024)

10 citations DOI OpenAlex
Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis (2024)

3 citations DOI OpenAlex
Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024)

24 citations DOI OpenAlex
A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone (2023)

1 citation DOI OpenAlex
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression (2023)

19 citations DOI OpenAlex
The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice (2023)

14 citations DOI OpenAlex