Martin Hauer‐Jensen
Retired
Also affiliated: Tokyo Institute of Technology (2000); University of Iowa (1986–1990); Oslo University Hospital (1986–1994); American Heart Association (2006); Boston Medical Center (2010); National Institutes of Health (2001–2010); Memorial Sloan Kettering Cancer Center (2010); New York Blood Center (2001); Thomas Jefferson University (2010); University of Oslo (1986–1990); Medical College of Wisconsin (2010); University of Arkansas Medical Center (1997–2025); Maastricht University Medical Centre (2010); Henry Ford Hospital (2010); Moffitt Cancer Center (2012); Maastricht University (2010); Central Arkansas Veterans Healthcare System (1999–2018); Diakonhjemmet Hospital (1980–1986); Iowa City VA Medical Center (1987); National Cancer Institute (2010); Lovisenberg Diakonale Sykehus (1986); Arkansas Biosciences Institute (2006); John L. McClellan Memorial Veterans Hospital (1993–2009); Maastro Clinic (2010); University of Florida Cancer Hospital (2010); UF Health Cancer Center (2010); University of Bergen (2000); Charité - Universitätsmedizin Berlin (2012)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Martin Hauer‐Jensen, a retired researcher from the University of Arkansas for Medical Sciences, has a scholarly career marked by extensive work in radiation biology and its associated medical countermeasures. His research has focused on understanding the mechanisms of radiation injury, particularly its early and late effects on normal tissues and organs. This work has informed radiation protection contexts by defining threshold doses for tissue reactions.
Hauer‐Jensen has investigated animal models for evaluating agents intended for the prophylaxis, mitigation, and treatment of radiation injuries. His publications also touch upon the broader implications of radiation therapy, including its impact on mucosal injury and the development of conditions like radiation enteropathy. His research network includes collaborators such as Vijayalakshmi Sridharan, Benjamin J. Lieblong, Isabelle R. Miousse, and Rupak Pathak, with whom he has co-authored multiple publications.
With a significant body of work, Hauer‐Jensen has achieved a high-impact researcher designation, evidenced by an h-index of 65 and over 18,000 citations across more than 330 publications. His recent activity indicates continued engagement in the field, with a publication as recent as 2026.
Metrics
- h-index: 66
- Publications: 330
- Citations: 18,244
Positions
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Retired publications 1992–2026University of Arkansas for Medical Sciences Pharmaceutical Sciences ORCID
Selected Publications
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Serum Proteomic Signatures in Nonhuman Primates after Treatment with a Radiation Countermeasure and Exposure to a Partial- or Total-body Supralethal Radiation Dose (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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Serum Metabolomic Signatures in Nonhuman Primates Treated with a Countermeasure and Exposed to Partial- or Total-Body Radiation (2025)
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Pathology of acute sub-lethal or near-lethal irradiation of nonhuman primates prophylaxed with the nutraceutical, gamma tocotrienol (2024)
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Don't CUT: Respecting the Potency of Radiation (2024)
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Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol (2024)
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Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation (2023)
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Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model (2022)
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Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model (2022)
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Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese (2022)
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Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate (2022)
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Randomised single centre double-blind placebo controlled phase II trial of Tocovid SupraBio in combination with pentoxifylline in patients suffering long-term gastrointestinal adverse effects of radiotherapy for pelvic cancer: The PPALM study (2022)
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Methods for induction and assessment of intestinal permeability in rodent models of radiation injury (2022)
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Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure (2021)
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Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells (2021)
Collaboration Network
Top Collaborators
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy
- Effects of ionizing radiation on the heart
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
- γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism
- Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol
Showing 5 of 49 shared publications
- EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
- PARP1 is required for chromosomal translocations
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
Showing 5 of 35 shared publications
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy
- Deficiency of Microvascular Thrombomodulin and Up-Regulation of Protease-Activated Receptor-1 in Irradiated Rat Intestine
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
- Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
Showing 5 of 22 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
Showing 5 of 20 shared publications
- Deficiency of Microvascular Thrombomodulin and Up-Regulation of Protease-Activated Receptor-1 in Irradiated Rat Intestine
- Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation
- Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
- Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?
Showing 5 of 18 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart
Showing 5 of 18 shared publications
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Densely ionizing radiation affects DNA methylation of selective LINE-1 elements
- In VitroToxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
Showing 5 of 18 shared publications
- Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
- Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates
- Gamma-Tocotrienol Protects Hematopoietic Stem and Progenitor Cells in Mice after Total-Body Irradiation
- Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor
- Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival
Showing 5 of 17 shared publications
- Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology
- Influence of Sublethal Total-Body Irradiation on Immune Cell Populations in the Intestinal Mucosa
- Pentoxifylline Enhances the Radioprotective Properties of γ-Tocotrienol: Differential Effects on the Hematopoietic, Gastrointestinal and Vascular Systems
- Procalcitonin as a Predictive Biomarker for Total Body Irradiation–Induced Bacterial Load and Lethality in Mice
- Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon
Showing 5 of 17 shared publications
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice
- EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair
- PARP1 is required for chromosomal translocations
- M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion
Showing 5 of 16 shared publications
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
- γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism
- Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
Showing 5 of 15 shared publications
- Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
- γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism
- Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates
- Gamma-Tocotrienol Protects Hematopoietic Stem and Progenitor Cells in Mice after Total-Body Irradiation
- Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin
Showing 5 of 15 shared publications
- γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism
- Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation
- Recombinant soluble transforming growth factor β type II receptor ameliorates radiation enteropathy in mice
- Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome
- Radiation injury and the protein C pathway
Showing 5 of 15 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model
- One-carbon metabolism and ionizing radiation: a multifaceted interaction
- Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol
Showing 5 of 11 shared publications
- Use of biomarkers for assessing radiation injury and efficacy of countermeasures
- Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates
- γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status
- Effects of Gamma-Tocotrienol on Intestinal Injury in a GI-Specific Acute Radiation Syndrome Model in Nonhuman Primate
- Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model
Showing 5 of 11 shared publications
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