Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
M
Mitchell R. McGill
Federal Grant PI
High Impact
Assistant Professor
Also affiliated: University of Arizona (2014); University of Kansas (2012–2015); Inserm (2012); Washington University in St. Louis (2016–2018); University College Cork (2021); University of Arkansas Medical Center (2018–2019); Good Samaritan Medical Center (2014); Public Health Department (2025); Office of Dietary Supplements (2024); Hôpital Pontchaillou (2012); University of Kansas Medical Center (2008–2020); Arkansas Department of Agriculture (2025); Arkansas Department of Health (2019–2025); Université de Rennes (2012); The University of Texas Southwestern Medical Center (2014)
Faculty Researcher
Environmental Health Sciences, College of Public Health
46 h-index
151 pubs
12,549 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Mitchell R. McGill investigates the mechanisms underlying acetaminophen-induced liver injury and potential therapeutic interventions. His research group focuses on identifying biomarkers for predicting patient outcomes and understanding the metabolic pathways involved in liver protection and regeneration. A notable area of his work involves studying the role of specific signaling pathways, such as those involving interleukin-6, and the impact of exogenous compounds like phosphatidic acid in mitigating liver damage.
His work has led to a significant body of research, indicated by his h-index of 46 and over 12,000 citations across more than 150 publications. McGill has received federal funding for his research, including a $328,034 award from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases to investigate the role of phosphatidic acid in liver regeneration following acetaminophen overdose. He actively collaborates with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville.
Metrics
- h-index: 46
- Publications: 151
- Citations: 12,549
Selected Publications
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Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers (2026)
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(6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells (2026)
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Special Issue “Mechanistic and Prognostic Biomarkers in Liver Diseases” (2025)
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From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure (2025)
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Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025)
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Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury (2025)
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NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)
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Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity (2024)
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Intracellular signaling mechanisms of acetaminophen-induced cell death (2024)
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Translation of acetaminophen hepatotoxicity mechanisms from models to humans (2024)
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Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
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Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024)
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The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans (2023)
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The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review (2023)
Federal Grants 1 $328,034 total
NIH
Contact PI
Mar 2024 - Feb 2029
The role of phosphatidic acid in liver regeneration after acetaminophen overdose
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- In-vitro assessment of the protective effects of selected ingredients against acetaminophen hepatotoxicity Haleon PLC Principal Investigator
Collaboration Network
Top Collaborators
Stefanie Kennon‐McGill
University of Arkansas for Medical Sciences
9 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 9 shared publications
Joel H. Vazquez
University of Arkansas for Medical Sciences
7 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?
Showing 5 of 7 shared publications
Laura P. James
Arkansas Department of Agriculture
6 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
- NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen
Showing 5 of 6 shared publications
Hartmut Jaeschke
University of Kansas Medical Center (US)
5 shared publications
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Biomarkers of mitotoxicity after acute liver injury: further insights into the interpretation of glutamate dehydrogenase
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
- Intracellular signaling mechanisms of acetaminophen-induced cell death
- Special Issue “Mechanistic and Prognostic Biomarkers in Liver Diseases”
Eric U. Yee
University of Arkansas for Medical Sciences
5 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice
Felicia D. Allard
University of Arkansas for Medical Sciences
4 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice
Igor Koturbash
Office of Dietary Supplements
4 shared publications
In database
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells
Brian N. Finck
Washington University in St. Louis (US)
3 shared publications
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice
Jonathan A. Dranoff
University of Arkansas for Medical Sciences (US)
3 shared publications
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
Alexander J. Layman
Arkansas Department of Health
3 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings
Sandra McCullough
University of Arkansas for Medical Sciences (US)
2 shared publications
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
Jeffery H. Moran
University of Arkansas for Medical Sciences
2 shared publications
In database
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
Samuel E. Mathews
2 shared publications
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
2 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
D. Keith Williams
University of Arkansas for Medical Sciences
2 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling
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