Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
M
Mitchell R. McGill
Federal Grant PI
High Impact
Assistant Professor
Also affiliated: Inserm (2012); Washington University in St. Louis (2016–2018); University College Cork (2021); University of Arkansas Medical Center (2023); The University of Kansas Health System (2014); Banner - University Medical Center Phoenix (2014); Hôpital Pontchaillou (2012); University of Kansas Medical Center (2008–2020); Université Rennes 1 (2012); University of Arizona College of Medicine- Phoenix (2014); Université de Rennes (2012); The University of Texas Southwestern Medical Center (2014)
Environmental Health Sciences, College of Public Health
46 h-index
152 pubs
12,656 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Mitchell R. McGill investigates the mechanisms underlying acetaminophen-induced liver injury and potential therapeutic interventions. His research group focuses on identifying biomarkers for predicting patient outcomes and understanding the metabolic pathways involved in liver protection and regeneration. A notable area of his work involves studying the role of specific signaling pathways, such as those involving interleukin-6, and the impact of exogenous compounds like phosphatidic acid in mitigating liver damage.
His work has led to a significant body of research, indicated by his h-index of 46 and over 12,000 citations across more than 150 publications. McGill has received federal funding for his research, including a $328,034 award from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases to investigate the role of phosphatidic acid in liver regeneration following acetaminophen overdose. He actively collaborates with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville.
Metrics
- h-index: 46
- Publications: 152
- Citations: 12,656
Positions
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Associate Professor 2023–presentUniversity of Arkansas for Medical Sciences ORCID
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Assistant Professor 2017–presentUniversity of Arkansas for Medical Sciences Environmental Health Sciences, College of Public Health Institutional directory
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Postdoctoral Fellow 2015–2017Washington University in St. Louis School of Medicine ORCID
Selected Publications
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Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers (2026)
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(6S)-5-Methyltetrahydrofolate Dicholine Salt Modulates Methyl-Donor Metabolites and Repetitive-Element DNA Methylation in HepaRG Cells (2026)
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Special Issue “Mechanistic and Prognostic Biomarkers in Liver Diseases” (2025)
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From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure (2025)
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Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025)
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Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury (2025)
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NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)
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Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity (2024)
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Intracellular signaling mechanisms of acetaminophen-induced cell death (2024)
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Translation of acetaminophen hepatotoxicity mechanisms from models to humans (2024)
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Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans (2024)
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Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)
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Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024)
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The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans (2023)
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The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review (2023)
Federal Grants 1 $328,034 total
NIH
Contact PI
Mar 2024 - Feb 2029
The role of phosphatidic acid in liver regeneration after acetaminophen overdose
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- In-vitro assessment of the protective effects of selected ingredients against acetaminophen hepatotoxicity Haleon PLC Principal Investigator
Collaboration Network
Top Collaborators
Stefanie Kennon‐McGill
University of Arkansas for Medical Sciences
19 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration
- The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling
Showing 5 of 19 shared publications
Laura P. James
Arkansas Department of Agriculture
13 shared publications
In database
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration
- The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
Showing 5 of 13 shared publications
Hartmut Jaeschke
University of Kansas Medical Center (US)
13 shared publications
- Animal models of drug-induced liver injury
- Biomarkers of drug-induced liver injury
- Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration
Showing 5 of 13 shared publications
Joel H. Vazquez
University of Arkansas for Medical Sciences
10 shared publications
In database
- Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
Showing 5 of 10 shared publications
Melissa M. Clemens
University of Arkansas for Medical Sciences
8 shared publications
In database
- Mechanisms and biomarkers of liver regeneration after drug-induced liver injury
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration
- The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
Showing 5 of 8 shared publications
Igor Koturbash
Office of Dietary Supplements
8 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Showing 5 of 8 shared publications
Eric U. Yee
University of Arkansas for Medical Sciences
8 shared publications
In database
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 8 shared publications
Brian N. Finck
Washington University in St. Louis (US)
7 shared publications
- Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration
- The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Monoacylglycerol Acyltransferase 1 Knockdown Exacerbates Hepatic Ischemia/Reperfusion Injury in Mice With Hepatic Steatosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
Showing 5 of 7 shared publications
Bill J. Gurley
Office of Dietary Supplements
7 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
Showing 5 of 7 shared publications
Sandra McCullough
University of Arkansas for Medical Sciences (US)
6 shared publications
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
- Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways
- Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect
Showing 5 of 6 shared publications
Laura Ewing
University of Arkansas for Medical Sciences
6 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 6 shared publications
Charles M. Skinner
University of Arkansas for Medical Sciences
6 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
Showing 5 of 6 shared publications
Charles M. Quick
University of Arkansas for Medical Sciences
5 shared publications
In database
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome
Larry Walker
University of Mississippi (US)
5 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome
Mahmoud A. ElSohly
University of Mississippi (US)
5 shared publications
- Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
- Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
- Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration
- Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract
- Cannabidiol: From Drug Interaction Potential to Modulation of the Gut Microbiome
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