N
Nan Mei Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Scientist
staff
42 h-index
188 pubs
9,278 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Nan Mei's research focuses on evaluating the genotoxicity and mutagenicity of various chemical compounds, particularly in the context of environmental pollution and potential human health impacts. Her work often involves in vitro assays using human cell lines, such as TK6 cells, and bacterial systems like the Ames test, to assess DNA damage and mutation potential. She also investigates the role of metabolic enzymes, specifically cytochrome P450s (CYPs), in modulating the toxicity of these substances.
Her recent publications address the genotoxicity of compounds like luteolin and N-nitrosamines, examining how factors such as CYP expression influence these effects. Mei has also studied the sources and levels of heavy metal contamination in agricultural soils and the long-term effects of different fertilization practices on soil microbial communities. These investigations contribute to understanding environmental exposures and their biological consequences.
Mei collaborates with several researchers at the National Center for Toxicological Research, including Robert H. Heflich, Yuan Le, Ji-Eun Seo, and Xilin Li, with whom she has co-authored multiple publications. Her scholarly output is substantial, with 188 total publications and an h-index of 42, indicating a significant body of work recognized for its impact, as evidenced by her designation as a highly cited researcher.
Metrics
- h-index: 42
- Publications: 188
- Citations: 9,278
Selected Publications
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Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of <i>N</i> ‐Nitrosamines (2026)
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025)
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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A proposed screening strategy for evaluating the genotoxicity potential of botanicals and botanical extracts (2025)
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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024)
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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
Collaboration Network
Top Collaborators
Xiaoqing Guo
National Center for Toxicological Research
15 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 15 shared publications
Si Chen
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells
Showing 5 of 10 shared publications
Xilin Li
Genetic Analysis (Norway) (NO)
10 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
Showing 5 of 10 shared publications
Lei Guo
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells
- Genotoxicity evaluation of nutraceuticals
Showing 5 of 10 shared publications
Robert H. Heflich
United States Food and Drug Administration
10 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 10 shared publications
Yuan Le
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Showing 5 of 10 shared publications
Ji‐Eun Seo
National Center for Toxicological Research
8 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 8 shared publications
Aisar Atrakchi
Center for Drug Evaluation and Research (US)
7 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
Showing 5 of 7 shared publications
Xilin Li
United States Food and Drug Administration
7 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Showing 5 of 7 shared publications
Xiaobo He
National Center for Toxicological Research
6 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Showing 5 of 6 shared publications
Yuxi Li
National Center for Toxicological Research (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Showing 5 of 6 shared publications
Timothy J. McGovern
United States Food and Drug Administration (US)
6 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Showing 5 of 6 shared publications
Matthew Bryant
National Center for Toxicological Research
5 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Mugimane G. Manjanatha
National Center for Toxicological Research
5 shared publications
In database
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
David A. Keire
United States Food and Drug Administration (US)
5 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
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