N
Nathan C. Twaddle Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Senior Scientist / Toxicologist
faculty
34 h-index
67 pubs
4,094 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Nathan C. Twaddle's research focuses on the toxicological effects of various chemical compounds and environmental factors on biological systems, utilizing animal models and advanced analytical techniques. His work has investigated the impact of inorganic arsenic on neuronal development and cellular processes in zebrafish, exploring the underlying molecular pathways, including the Sonic hedgehog pathway. He has also examined the effects of dietary soy protein, with varying isoflavone levels, on metabolic health, including liver steatosis and serum inflammatory markers in rat models, particularly in the context of non-alcoholic fatty liver disease.
Twaddle's research extends to the analysis of elemental impurities in substances such as cannabis following vaporization. His work often involves collaborations with researchers at the National Center for Toxicological Research and the University of Arkansas for Medical Sciences, contributing to a body of work that has resulted in over 60 publications and significant citation counts. His h-index of 34 and total citations of over 4,000 indicate a highly cited researcher in his field.
Metrics
- h-index: 34
- Publications: 67
- Citations: 4,094
Selected Publications
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Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development (2025)
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Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024)
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Analysis of elemental impurities in cannabis following vaporization (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model (2022)
Collaboration Network
Top Collaborators
Reza Hakkak
Arkansas Children's Hospital
3 shared publications
In database
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Beverly J. Spray
Arkansas Children's Hospital (US)
3 shared publications
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Jyotshna Kanungo
United States Food and Drug Administration
3 shared publications
In database
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development
Camila Silva
United States Food and Drug Administration
3 shared publications
In database
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development
Frederick A. Beland
National Center for Toxicological Research
3 shared publications
In database
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Acetyl L‐Carnitine Protects Zebrafish Embryos From Verapamil and Inorganic Arsenic‐Induced Cardiotoxicity and Developmental Toxicity With No Effect on Supernumerary Motor Neuron Development
Soheila Korourian
University of Arkansas for Medical Sciences
2 shared publications
In database
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Bonnie Robinson
National Center for Toxicological Research
2 shared publications
In database
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Qiang Gu
National Center for Toxicological Research
2 shared publications
In database
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Suzanne Fitzpatrick
Center for Food Safety and Applied Nutrition (US)
2 shared publications
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
David M. Irby
1 shared publication
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Mesay Mulugeta Wolle
United States Food and Drug Administration (US)
1 shared publication
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
Sean D. Conklin
Center for Food Safety and Applied Nutrition (US)
1 shared publication
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
Shaun MacMahon
Center for Food Safety and Applied Nutrition (US)
1 shared publication
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
Ian Edhlund
Center for Veterinary Medicine (US)
1 shared publication
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
Linda Benjamin
Center for Veterinary Medicine (US)
1 shared publication
- Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish
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