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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
N
Nicholas Callais
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Also affiliated: Arkansas Children's Hospital (2024)
2 h-index
4 pubs
9 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nicholas Callais's research investigates the role of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in regulating T-cell responses, particularly in the context of cancer and organ transplantation. His work has shown that DNA-PKcs controls cytotoxic T-cell responses by modulating LAT-dependent signaling in both CD4+ and CD8+ T cells. This regulation is significant for the body's response to cancer and the survival of transplanted organs. Callais also explores novel mechanisms of T-cell signaling regulation by DNA-PKcs. Additionally, his research includes the application of machine learning to virtual biopsy systems, with a noted potential impact on organ discards in kidney transplant centers. His collaborators at the University of Arkansas for Medical Sciences include Hailey Hardgrave, Emmaouil Giorgakis, Kaitlin Hicks, and Ana Azevedo-Pouly.
Metrics
- h-index: 2
- Publications: 4
- Citations: 9
Selected Publications
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Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression (2026)
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L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival (2026)
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DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling (2025)
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DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells (2025)
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Machine learning-driven virtual biopsy system may increase organ discards at aggressive kidney transplant centers (2024)
Collaboration Network
Top Collaborators
Ana Clara P. Azevedo‐Pouly
Arkansas Children's Hospital
4 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival
- Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression
Marie Burdine
Arkansas Children's Hospital
4 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival
- Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression
Lyle J. Burdine
University of Arkansas for Medical Sciences
3 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival
Randall R Rainwater
Arkansas Children's Hospital
2 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression
Zachary J. Waldrip
University of Arkansas for Medical Sciences
2 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
Brian S. Koss
University of Arkansas for Medical Sciences
2 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
Aaron J. Storey
Arkana Laboratories
2 shared publications
In database
- DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
Randall Rainwater
University of Arkansas for Medical Sciences
2 shared publications
In database
- DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling
- L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival
Emmanouil Giorgakis
University of North Carolina at Chapel Hill
1 shared publication
In database
- Machine learning-driven virtual biopsy system may increase organ discards at aggressive kidney transplant centers
Hailey Hardgrave
University of Arkansas for Medical Sciences
1 shared publication
In database
- Machine learning-driven virtual biopsy system may increase organ discards at aggressive kidney transplant centers
Allison Wells
University of Arkansas for Medical Sciences
1 shared publication
In database
- Machine learning-driven virtual biopsy system may increase organ discards at aggressive kidney transplant centers
Tsukasa Nakamura
University of Arkansas for Medical Sciences
1 shared publication
In database
- L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival
Kaitlin Hicks
University of Arkansas for Medical Sciences
1 shared publication
In database
- L15. T Cell-Specific Loss of DNA-PKcs Enhances Allogeneic Cardiac Graft Survival
Shawn Welch
University of Arkansas for Medical Sciences
1 shared publication
In database
- Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression
John Schaller
Arkansas Children's Hospital
1 shared publication
In database
- Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression
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