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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
B
Brian S. Koss
Federal Grant PI
Assistant Professor
Also affiliated: La Jolla Institute for Immunology (2025); St. Jude Children's Research Hospital (2010–2019)
Biochemistry & Molecular Biology, College of Medicine
17 h-index
77 pubs
2,054 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Brian S. Koss investigates the molecular mechanisms that regulate cell survival and death, with a particular focus on the anti-apoptotic protein MCL-1. His research has elucidated the mitochondrial localization of MCL-1 and its role in coupling mitochondrial fusion to cellular respiration. He has also explored the consequences of MCL-1 deletion, demonstrating its critical requirement for cardiac function and the survival of specific leukemia cell types.
His federally funded research examines strategies to overcome the solid tumor microenvironment and T-cell exhaustion. Grants from the NIH support his work on T-cell proteome turnover dynamics, targeting E3 ligase RNF166 to prevent T-cell exhaustion, and exploring host GSK3β-53BP1 axis in immune control of solid tumors. He also co-PIs a project leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells.
Koss collaborates with researchers at the University of Arkansas for Medical Sciences, including Daniel Fil, Lora J. Rogers, Jacob L. Edmondson, and Jessica L. Kelliher, with whom he has co-authored multiple publications. His scholarship metrics include an h-index of 17, 77 total publications, and over 2,000 citations.
Metrics
- h-index: 17
- Publications: 77
- Citations: 2,054
Positions
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Assistant Professor 2021–presentUniversity of Arkansas for Medical Sciences Biochemistry & Molecular Biology, College of Medicine Institutional directory
Selected Publications
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Abstract 6545: Characterizing ATF6 activation-driven mechanisms improving ICB efficacy (2026)
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Abstract 5189: Generating EZH2-inhibitor resistant CAR-T cells to sustain function for combination therapy (2026)
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Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2026)
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling (2026)
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743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function (2025)
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685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025)
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691 ATF6 activation promotes ICB response in melanoma (2025)
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762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025)
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236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
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392 Donor-intrinsic proteomic programs shape CAR-T cell persistence across a longitudinal killing assay (2025)
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Comprehensive Analysis of Proteome Turnover Dynamics During T Cell Exhaustion (2025)
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma (2025)
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DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling (2025)
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DNA-PKcs governs LAT-dependent signaling in CD4 + and CD8 + T cells (2025)
Federal Grants 4 $1,988,099 total
NIH
Contact PI
Jul 2026 - Jun 2031
Targeting the E3 Ligase RNF166 to Prevent T-cell Exhaustion in Solid Tumors
NIH
Co-PI
May 2026 - Apr 2031
Exploring host GSK3β-53BP1 axis in immune control of solid tumor progression
NIH
Co-PI
Jun 2024 - May 2026
Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells
NIH
Contact PI
Sep 2021 - Aug 2026
Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironment
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes NIH/Nat. Cancer Institute Principal Investigator
- DNA-PKcs Regulation of LAT-Mediated Early TCR Signaling in CD4+ and CD8+ T Cells NIH Co-Principal Investigator
- Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission NIH Principal Investigator
- ABI B. Koss Startup FY26 Y5 State of Arkansas Principal Investigator
Collaboration Network
Top Collaborators
Alan J. Tackett
University of Arkansas for Medical Sciences
30 shared publications
In database
- Indicators of responsiveness to immune checkpoint inhibitors
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum
Showing 5 of 30 shared publications
Daniel Fil
University of Arkansas for Medical Sciences
22 shared publications
In database
- Chemical inhibition of DNA‐PKcs impairs the activation and cytotoxicity of CD4 + helper and CD8 + effector T cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
Showing 5 of 22 shared publications
Sydnye L. Shuttleworth
University of Arkansas for Medical Sciences
16 shared publications
In database
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
Showing 5 of 16 shared publications
Lora J. Rogers
University of Arkansas for Medical Sciences
15 shared publications
In database
- Chemical inhibition of DNA‐PKcs impairs the activation and cytotoxicity of CD4 + helper and CD8 + effector T cells
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 + helper and CD8 + effector T cells
- Abstract B015: Racial differences in epigenetic aging and its impact on expression of T-cell inhibitory receptors
Showing 5 of 15 shared publications
Aaron J. Storey
Arkana Laboratories
14 shared publications
In database
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Effect of Sulforaphane and 5-Aza-2’-Deoxycytidine on Melanoma Cell Growth
- DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling
Showing 5 of 14 shared publications
Billie Heflin
University of Arkansas for Medical Sciences
12 shared publications
In database
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
Showing 5 of 12 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
11 shared publications
In database
- CAR-T Therapies in Solid Tumors: Opportunities and Challenges
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract LB041: EZH2 and ATF6 sense metabolic stress to balance MHC class I antigen presentation in melanoma
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
Showing 5 of 11 shared publications
Jessica L Kelliher
University of Arkansas for Medical Sciences
11 shared publications
In database
- Evolved histone tail regulates 53BP1 recruitment at damaged chromatin
- 1020 Proteomic analysis of T cell exhaustion unveils differential modulation of the DNA damage response
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
Showing 5 of 11 shared publications
Jacob L Edmondson
University of Arkansas for Medical Sciences
11 shared publications
In database
- Role of NEK2 in tumorigenesis and tumor progression
- 536 EZH2 senses metabolic stress to restore MHC-I antigen presentation and ICB response in metastatic melanoma
- Abstract 584: Synergistic action of ATF6 and EZH2 in sensing metabolic stress to boost anti-tumor immunity
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion
Showing 5 of 11 shared publications
Stephanie D. Byrum
St. Jude Children's Research Hospital
10 shared publications
In database
- Indicators of responsiveness to immune checkpoint inhibitors
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Effect of Sulforaphane and 5-Aza-2’-Deoxycytidine on Melanoma Cell Growth
- Proteomic signatures of innate immunity in immunotherapy naïve melanomas correlate with anti-CTLA-4 immunotherapy responsiveness
Showing 5 of 10 shared publications
Katherine Wallis
University of Arkansas for Medical Sciences
10 shared publications
In database
- Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma
- Abstract 1577: Caloric restriction mimetics as adjuvant to immune checkpoint inhibitors for treatment of melanoma
- 932 Defining the role for PCK2 in T-cell metabolic plasticity
- 929 Proteomic analysis reveals differential modulation of the DNA damage response in exhausted T cells
- 538 ATF6 activation in melanoma promotes anti-tumor immunity and improves ICB therapy response
Showing 5 of 10 shared publications
Michael Bauer
University of Arkansas for Medical Sciences
9 shared publications
In database
- 1211 Defining the role of PCK2 in T cell metabolic plasticity in Glioblastoma
- EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma
- Abstract B015: Racial differences in epigenetic aging and its impact on expression of T-cell inhibitory receptors
- 255 Functional and multi-omic characterization of CAR T cells across healthy donors
- 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
Showing 5 of 9 shared publications
Erin M. Taylor
University of Arkansas for Medical Sciences
8 shared publications
In database
- Indicators of responsiveness to immune checkpoint inhibitors
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Histone Modifications as Biomarkers for Immunotherapy
- CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
Showing 5 of 8 shared publications
Samuel G. Mackintosh
University of Arkansas for Medical Sciences
8 shared publications
In database
- Indicators of responsiveness to immune checkpoint inhibitors
- PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Proteomic signatures of innate immunity in immunotherapy naïve melanomas correlate with anti-CTLA-4 immunotherapy responsiveness
Showing 5 of 8 shared publications
Bradley D. Shields
University of Arkansas for Medical Sciences (US)
7 shared publications
- Indicators of responsiveness to immune checkpoint inhibitors
- Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion
- Abstract 2037: E-cadherin enhances immune control of metastatic melanoma
- Abstract LB-206: Indicators of responsiveness to immune checkpoint inhibitors
Showing 5 of 7 shared publications
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